CaBP Data Library General Information

S100A10/P11

Primary information about S100A10/p11:
Basic chemical and physical information
Basic biological information
Basic genomic information
Metal ion binding constants
Interspecies sequence alignment
Information on function
Summary of structural studies
Information on the conformational change List of available structures Information about mutations
References about S100A10 Other web resources about S100A10
Additional information about S100A10/p11:
Information about the evolutionary relationship of S100A10/p11 to other proteins






Basic Information

Additional names and abbreviations: S100A10: calpactin light chain; CLP11; annexin II light chain (Anx2LC); 42C; p10
Isoforms: No information about isoforms is stored in the database
Yeast Protein Database Entries: No links to the YPD are stored in the database


Basic Chemical and Physical Information:
Number of amino acids: 94 (Rattus norvegicus) - 96 (Mus musculus, Homo sapiens, Gallus gallus)
View a list of all sources stored in the database
Molecular weight: 10.944 kD (Sus scrofa, Rattus norvegicus) - 11.159 kD (Gallus gallus)
View a list of all sources stored in the database
pI: not yet available in the data library
Number of functional calcium binding sites: Bos taurus: 0 (InfoCard)
Macroscopic calcium binding constants: not yet available in the data library
Other metal binding constants: not yet available in the data library
Protein stability: not yet available in the data library
Post-translational modifications: not yet available in the data library


Basic Biological Information:
Source organisms: Gallus gallus, Homo sapiens, Mus musculus, Sus scrofa, Rattus norvegicus
View an annotated list of all sources stored in the database
Tissues: not yet available in the data library
Subcellular localization: not yet available in the data library
Regulation: not yet available in the data library


Genomic Information:
GenBank entries: View a list of GenBank entries stored in the database
Gene length: not yet available in the data library
Gene structure: not yet available in the data library
Promoter: not yet available in the data library
Gene copies: not yet available in the data library
Alleles: no alleles are currently stored in the data library
Chromosomal localization: Homo sapiens, expressed (GenBank code M38591): q21 region of chromosome 1 (part of the cluster of S100 protein genes) (InfoCard)
Mus musculus, expressed (GenBank code M16465): chromosome 3 (InfoCard)

Interspecies Sequence Alignment




                       |-helixA-|--loop1------|helixB| 
                       En**nn**nX**Y*Z**#Ix**zn**nn*n          

HUMAN   :     PSQMEHAMETMMFTFHKFAGDKGY---LTKEDLRVLMEKEFPGFLENQKDPL
MOUSE   :     PSQMEHAMETMMLTFHRFAGDKDH---LTKEDLRVLMEREFPGFLENQKDPL
RAT     :     PSQMEHAMETMMLTFHRFAGEKNY---LTKEDLRVLMEREFPGFLENQKDPL
PORCINE :     PSQMEHAMETMMFTFHKFAGDKGY---LTKEDLRVLMEKEFPGFLENQKDPL
CHICK   :     PSQMEHAMETLMFTFHKYAGDKNY---LSKEDLRALMEKEFPGFLENQRDPM

         |-helixC-|--loop2-----|helixD|
          En**nn**nX*Y*ZG#Ix**zn**nn*n

HUMAN   : AVDKIMKDLDQCRDGKVGFQSFFSLIAGLTIACNDYFVVHMKQKGKK
MOUSE   : AVDKIMKDLDQCRDGKVGFQSFLSLVAGLTIACNDYFVVNMKQKGKK
RAT     : AVDKIMKDLDQCRDGKVGFQSFLSLVAGLIIACNDYFVVHMKQKK
PORCINE : AVDKIMKDLDQCRDGKVGFQSFFSLIAGLTIACNDYFVVHMKQKGK
CHICK   : ALDKIMKDLDQCRDGKVGFQSFFSLVAGLTIACNDYFVVHMKQKGRK


Sequence alignment of the entire S100 subfamily

Functional Information:

General information:

Biological roles:

Disease states:

Target molecules:


Structural Information:

Calcium-coordination:
not yet available in the data library


Nature of the conformational changes:
not yet available in the data library


Secondary structure:
(as reported in the PDB file and its accompanying reference)
not yet available in the data library


Additional structural information:


Available structures:
(follow the links from the PDB code to the retrieve the
PDB files)
Apo Structures:
1A4P: Homo sapiens, homodimer, pH 7.5
Crystal structure, 2.25 angstrom resolution, R-value = 24.6, R-free = 30.3
(InfoCard)
Target Peptide Bound Structures:
1BT6: Homo sapiens, homodimer complexed to annexin peptide, pH 7.5
Crystal structure, 2.4 angstrom resolution, R-value = 23.3, R-free = 22.8
(InfoCard)

Information about mutants: