CaBP Data Library General Information

Spectrin

Primary information about spectrin:
Basic chemical and physical information
Basic biological information
Basic genomic information
Metal ion binding constants
Interspecies sequence alignment
Information on function
Summary of structural studies
Information on the conformational change List of available structures Information about mutations
References about spectrin Other web resources about spectrin

Basic Information

Additional names and abbreviations: spectrin: calspectin; brain actin-binding protein (BABP)
Isoforms: brain isoform alpha chain
erythroid isoform alpha chain
Yeast Protein Database Entries: No links to the YPD are stored in the database


Basic Chemical and Physical Information:
Number of amino acids: brain isoform alpha chain: 2472 (Homo sapiens) - 2477 (Gallus gallus)
erythroid isoform alpha chain: 2415 (Drosophila melanogaster) - 2418 (Homo sapiens)
View a list of all sources stored in the database
Molecular weight: brain isoform alpha chain: 284.279 kD (Homo sapiens) - 285.361 kD (Gallus gallus)
erythroid isoform alpha chain: 278.328 kD (Drosophila melanogaster) - 279.913 kD (Homo sapiens)
View a list of all sources stored in the database
pI: not yet available in the data library
Number of functional calcium binding sites: not yet available in the data library
Macroscopic calcium binding constants: not yet available in the data library
Other metal binding constants: not yet available in the data library
Protein stability: not yet available in the data library
Post-translational modifications: not yet available in the data library


Basic Biological Information:
Source organisms: brain isoform alpha chain: Gallus gallus, Homo sapiens
erythroid isoform alpha chain: Drosophila melanogaster, Homo sapiens
View an annotated list of all sources stored in the database
Tissues: not yet available in the data library
Subcellular localization: not yet available in the data library
Regulation: not yet available in the data library


Genomic Information:
GenBank entries: not yet available in the data library
Gene length: not yet available in the data library
Gene structure: not yet available in the data library
Promoter: not yet available in the data library
Gene copies: not yet available in the data library
Alleles: no alleles are currently stored in the data library
Chromosomal localization: not yet available in the data library

Interspecies Sequence Alignment


                            |-helixI-|--loop1----|helixII|
                             En**nn**nX*Y*ZG#Ix**zn**nn*n

CHICK          : RNTTGVAEEALKEFSMMFKHFDKDKSGRLDHQEFKSCLRS
CHICK(NONERYTH): RNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRS
HUMAN(ERYTH)   : KDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRG
DROSOP         : RNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRA

                               |helixIII|--loop2----|helixIV| 
                                En**nn**nX*Y*ZG#Ix**zn**nn*n  

CHICK          : LGYDLPMVEEGEPDPEFESILDTVDPNRDGHVSLQEYMAFMISR
CHICK(NONERYTH): LGYDLPMVEEGEPDPEFESILDTVDPNRDGHVSLQEYMAFMISR
HUMAN(ERYTH)   : LNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDK
DROSOP         : LGYDLPMVEEGQPDPEFEAILDVVDPNRDGYVSLQEYIAFMISK


Sequence alignment of the entire spectrin alpha chains subfamily

Functional Information:

General information:

Biological roles:

Disease states:

Target molecules:


Structural Information:

Calcium-coordination:
not yet available in the data library


Nature of the conformational changes:
Conformational change between apo and two calcium ions bound states of brain isoform alpha chain:
Spectrin exhibits calcium-dependent opening in a calmodulin-like manner.
(InfoCard)


Secondary structure:
(as reported in the PDB file and its accompanying reference)
not yet available in the data library


Additional structural information:
no additional structural information is currently stored in the database


Available structures:
(follow the links from the PDB code to the retrieve the
PDB files)
no structures are currently stored in the database

Information about mutants: