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Past CSB News ArticlesNews posted by karen.d.davis@vanderbilt.edu: Corey Seacrist receives Dean's Award for Exceptional Achievement in Graduate StudiesCorey Seacrist, of the Blind Lab, was an inaugural recipient of the new Dean's Award for Exceptional Achievement in Graduate Studies, which honors outstanding graduate students in the School of Medicine who are entering their 4th year of study. The award provides each student $5,000/year of stipend support for two years. News posted by karen.d.davis@vanderbilt.edu: Research Spotlight: Hassane MchaourabCSB investigator Hassane Mchaourab and his lab have identified central structural-functional correlations of substrate and ion transport in a key MATE transporter. Read the PNAS paper. News posted by karen.d.davis@vanderbilt.edu: Marilyn Holt - Dissertation Defense 7/31/2018Marilyn Holt, of the Chazin Lab, presents: "Contribution to template priming from the human DNA primase [4Fe4S] cluster domain" on Tuesday, July 31, at 3:00pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Garrett Warren presents MBTP/CSB Seminar on 7/17/2018Garrett Warren, of the Eichman Lab, presents the MBTP/CSB Seminar: “Conformational dynamics of the RecG replication fork remodeler” on Tuesday, July 17, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Carlos Lopez presents MBTP/CSB Seminar on 7/3/2018Dr. Carlos Lopez, Biochemistry, presents the MBTP/CSB Seminar: “A systems approach to study reaction flux and information flow in an allosteric regulation networks” on Tuesday, July 3, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Ray Blind & Zdravka Tzankova present MBTP/CSB Seminar on 6/26/2018Dr. Ray Blind, Dept. of Medicine Diabetes Research Center, and Dr. Zdravka Tzankova, Sociology, present the RCR Special Session: "Can science and technology move too fast?" on Tuesday, June 26, at 12:20pm-1:10pm in 214 Light Hall. Please note the different location for this seminar. News posted by karen.d.davis@vanderbilt.edu: Veronica Farmer presents MBTP/CSB Seminar on 6/19/2018Veronica Farmer, of the Zanic Lab, presents the MBTP/CSB Seminar: "Investigating the role of the GTP hydrolysis rate in regulating microtubule dynamics" on Tuesday, June 19, at 12:20 - 1:10 pm in 202 Light Hall. News posted by karen.d.davis@vanderbilt.edu: Diana Chavez - Dissertation Defense 6/12/2018Diana Chavez, of the Eichman Lab, presents: "Replication Fork Remodeling by Helicase-Like Transcription Factor" on Tuesday, June 12, at 2:00 pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Ian Setliff presents MBTP/CSB Seminar on 5/15/2018Ian Setliff, of the Georgiev Lab, presents the MBTP/CSB Seminar: "Population-level Analysis of Antibody Responses to HIV-1 Infection" on Tuesday, May 15, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Tony Capra presents MBTP/CSB Seminar on 4/24/2018Dr. Tony Capra, Biological Sciences, presents the MBTP/CSB Seminar: “Integrating Structural Biology and Population Genetics to Enable Personalized Medicine” on Tuesday, April 24, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Brennica Marlow presents MBTP/CSB Seminar on 4/17/2018Brennica Marlow, of the Meiler Lab, presents the MBTP/CSB Seminar: “Modelling cholesterol interactions with membrane proteins” on Tuesday, April 17 at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Darwin Fu - Dissertation Defense 4/12/2018Darwin Fu, of the Meiler Lab, presents: "Improving Protein-Small Molecule Structure Predictions with Ensemble Methods, or Using Computers to Guess How Tiny Things Fit Together" on Thursday, April 12, at 11:15am in 8380-B Medical Center East. News posted by karen.d.davis@vanderbilt.edu: Steve Fesik expands partnership with Boehringer IngelheimCSB researcher Steve Fesik is launching a new partnership with Boehringer Ingelheim to discover and develop cancer therapies targeting MCL1. This is the third such partnership between the pharmaceutical giant and the Fesik lab. Congratulations!
News posted by karen.d.davis@vanderbilt.edu: Alyssa Rodriguez and Noah Bradley awarded NSF Research FellowshipsAlyssa Rodriguez and Noah Bradley, both of the Eichman Lab, have each been awarded a 2018 National Science Foundation (NSF) Graduate Research Fellowship. Each student will receive funding for three years.
News posted by karen.d.davis@vanderbilt.edu: Tim Cover presents MBTP/CSB Seminar on 4/3/2018Dr. Tim Cover, Medicine and Pathology, Microbiology & Immunology, presents the MBTP/CSB Seminar: "Helicobacter pylori toxins and protein secretion systems: structure, function and relevance to gastric cancer pathogenesis" on Tuesday, April 3, 2018 at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: William Wan presents MBTP/CSB Seminar on 3/27/2018Former MBTP trainee Dr. William Wan, Max Planck Institute of Biochemistry, presents the MBTP/CSB Seminar: "Determining structures in complex environments using cryo-electron tomography" on Tuesday, March 27, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Adrian Olivares presents MBTP/CSB Seminar on 3/6/2018Dr. Adrian Olivares, Biochemistry, presents the MBTP/CSB Seminar: "How cellular machines sense and use mechanical force for biochemical processes" on Tuesday, March 6, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: BRET Office presents MBTB/CSB Seminar on 2/27/2018Representatives from the BRET Office presents the MBTP/CSB Seminar: "The ASPIRE program and BRET Office of Career Development: Professional development resources for trainees" on Tuesday, February 27, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Ann McDermott presents MBTP/CSB Seminar on 2/20/2018Student invited speaker Ann McDermott, Columbia University, presents the MBTP/CSB Seminar: “Protein Dynamics in Signaling NMR Studies of Ion Channels and Amyloids” on Tuesday, February 20, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Amanda Duran - Dissertation Defense 2/15/2018Amanda Duran, of the Meiler Lab, presents: "Improving Membrane Protein Modeling and Design using Empirical Data" on Thursday, February 15, at 10:00 am in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Marija Zanic presents MBTP/CSB Seminar on 2/6/2018Marija Zanic, Cell & Developmental Biology, presents the MBTP/CSB Seminar: "Dynamic architecture of the microtubule cytoskeleton" on Tuesday, February 6, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Meredith Frazier receives Karpay AwardCongratulations to Meredith Frazier for being named the 2018 recipient of The Karpay Award in Structural Biology. “I am very honored to be recognized with the Karpay award,” Meredith said.
News posted by karen.d.davis@vanderbilt.edu: Axel Fischer - Dissertation Defense 1/10/2018Axel Fischer, of the Meiler Lab, presents: "In silico prediction of protein structures and ensembles" on Wednesday, January 10, at 1:00pm in 202 LH. News posted by karen.d.davis@vanderbilt.edu: Drew Kellum presents MBTP/CSB Seminar on 12/19/2017Drew Kellum, of the Stone Lab, presents the MBTP/CSB Seminar: "Structural Studies into Discrimination of O6-Methylguanine from Guanine by the Oligonucleotide Probe ExBIM in Duplex DNA" on Tuesday, December 19, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Bill Martin - Dissertation Defense 12/15/2017Bill Martin, of the Reiter and Egli Labs, presents: "RNA Recognition by the Histone Demethylase LSD1 and Proteinaceous RNaseP" on Friday, December 15, at 1:00pm in 208 Light Hall. News posted by karen.d.davis@vanderbilt.edu: Borden Lacy elected AAAS fellowCenter for Structural Biology core faculty member Borden Lacy, Ph.D., has been elected fellow of the American Association for the Advancement of Science (AAAS).
News posted by karen.d.davis@vanderbilt.edu: Ivelin Georgiev presents MBTP/CSB Seminar on 11/28/2017Dr. Ivelin Georgiev, Pathology, Microbiology & Immunology, presents the RCR Special Session: "Patenting your work: process and challenges" on Tuesday, November 28, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Marilyn Holt presents MBTP/CSB Seminar on 11/21/2017Marilyn Holt, of the Chazin Lab, presents the MBTP/CSB Seminar: "Optimus Primase: Investigating the transformations of primase during the catalytic cycle" on Tuesday, November 21, at 12:20pm-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Borden Lacy honored with endowed chairCongratulations to CSB core faculty member Borden Lacy, Ph.D., on being named to an endowed chair. She and other faculty members were honored by Provost and Vice Chancellor for Academic Affairs Susan R. Wente during an October 23 celebration.
News posted by karen.d.davis@vanderbilt.edu: Eva Nogales presents MBTP/CSB Seminar on 11/14/2017Dr. Eva Nogales, University of California - Berkeley, presents the MBTP/CSB Seminar: "Cryo-EM in the Study of Structure, Dynamics and Interactions" on Tuesday, November 14, at 12:20-1:10pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Steven Damo spotlighted for contributions to Fisk University's scientific researchCSB member and Fisk University assistant professor Steven Damo, Ph.D., was recently featured on Nashville Public Radio as one of the institution’s rising research stars. Read the online article on the Nashville Public Radio website. News posted by karen.d.davis@vanderbilt.edu: Yan Xia - Dissertation DefenseYan Xia, of the Meiler Lab, presents: "Integrated Structural Biology for Understanding Membrane Proteins: A TSPO Story" on Wednesday, November 15, at 8:00 am in 202 Light Hall. News posted by karen.d.davis@vanderbilt.edu: Matthew Tyska presents MBTP/CSB Seminar on 10/3/2017Dr. Matthew Tyska, Cell & Developmental Biology, presents the MBTP/CSB Seminar: "Building the brush border: shaping the cell surface with actin polymerization and adhesion" on Tuesday, October 3, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Piotr Sliz presents MBTP/CSB Seminar on 9/26/2017Dr. Piotr Sliz, Harvard Medical School, presents the MBTP/CSB Seminar: "SBGrid: a computing environment for structural and computational biologists" on Tuesday, September 26, at 12:30pm-1:20 pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Marion Sauer presents MBTP/CSB Seminar on 9/19/2017Marion Sauer, of the Meiler Lab, presents the MBTP/CSB Seminar: "Working towards hitting a moving target: Predicting glycoprotein intermediate backbone and sequence dynamics" on Tuesday, September 19, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Borden Lacy presents MBTP/CSB Seminar on 9/5/2017Dr. Borden Lacy, Pathology, Microbiology & Immunology, presents the MBTP/CSB Seminar: "Structures and Functions of the Clostridium difficile toxins TcdA and TcdB" on Tuesday, September 5, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Lauren Salay presents MBTP/CSB Seminar on 8/15/2017Lauren Salay, of the Chazin Lab, presents the MBTP/CSB Seminar: "Do the Fe-S cluster and charge transport through DNA have roles in template priming by DNA primase?" on Tuesday, August 15, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Darwin Fu presents MBTP/CSB Seminar on 7/25/2017Darwin Fu, of the Meiler Lab, presents the RCR Special Session: "#SciComm: Outreach in the age of social media" on Tuesday, July 25, at 12:30pm-1:20pm in 512 Light Hall.
News posted by karen.d.davis@vanderbilt.edu: Brett Collins presents the BioSci/CSB Seminar on 7/24/2017Brett Collins, University of Queensland, presents: "The endosome at atomic resolution" at a special seminar sponsored by Biological Sciences & Center for Structural Biology on Monday, July 24, at 3:10 pm in 214 Light Hall. News posted by karen.d.davis@vanderbilt.edu: CSB receives funding for TIPs intiativeVanderbilt University has awarded funding to the Center for Structural Biology (CSB) Trans-Institutional Programs (TIPs) initiative: “A Reinvestment in Cryo-Electron Microscopy at Vanderbilt – VRA.” Initiative participants include CSB faculty and School of Medicine clinical faculty.
News posted by karen.d.davis@vanderbilt.edu: Introduction to DEER Spectroscopy Workshop - 7/31/2017Join us for the Introduction to DEER Spectroscopy Workshop on Monday, July 31, from 9:30am-5:00pm in 419-D Light Hall. News posted by karen.d.davis@vanderbilt.edu: Justin Marinko presents MBTP/CSB Seminar on 7/18/2017Justin Marinko, of the Sanders Lab, presents the MBTP/CSB Seminar: "There and Back Again a Proteins Tale: Function and Intracellular Trafficking of Peripheral Myelin Protein 22 (PMP22)" on Tuesday, July 18, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Chrystal Starbird - Dissertation Defense 7/17/2017Chrystal Starbird, of the Iverson Lab, presents: "Structural insights into the role of assembly factors in the assembly, function and flavinylation of Complex II" on Monday, July 17, at 11:00 am in 206 Preston Research Building. News posted by karen.d.davis@vanderbilt.edu: Ray Blind presents MBTB/CSB Seminar on 7/11/2017Dr. Ray Blind, Department of Medicine, presents the MBTP/CSB Seminar: "Crystal structure of the human IPMK orthologue: implications for drug design and gene regulation" on Tuesday, July 11, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Research Spotlight - Walter ChazinCSB Researcher Walter Chazin, Ph.D., Postdoctoral Fellow Aaron Ehlinger, Ph.D., and colleagues have shown that an ancient primase polymerase – PrimPol – helps replicate DNA from cell to cell where there is damage to DNA.
News posted by karen.d.davis@vanderbilt.edu: Joe Alvin - Dissertation Defense 6/22/2017Joe Alvin, of the Lacy Lab, presents: "Structural and functional studies of large clostridial toxin glucosyltransferase domains" on Thursday, June 22, at 10:00am in 206 Preston Research Building. News posted by karen.d.davis@vanderbilt.edu: Cheryl Law presents MBTP/CSB Seminar on 6/20/2017Cheryl Law, of the Sanders Lab, presents the MBTP/CSB Seminar: "Structural studies of triple mutant KCNE1TVG" on Tuesday, June 20, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Steffen Lindert presents the MBTP/CSB Seminar on 6/13/2017Dr. Steffen Lindert, Ohio State University, presents the MBTP/CSB Special Seminar: "CryoEM-Guided Iterative Molecular Dynamics – Rosetta Protein Structure Refinement Protocol Improves Protein Model Quality" on Tuesday, June 13, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: CSB researchers honored as emeriti facultyCongratulations to CSB Researchers Al Beth and Paul Bock on being honored with the emeritus title. Drs. Beth and Bock were among the thirty-two retiring faculty members to be recognized during Vanderbilt's Commencement ceremony on May 12.
News posted by karen.d.davis@vanderbilt.edu: Puck Ohi presents MBTP/CSB Seminar on 6/6/2017Dr. Ryoma "Puck" Ohi, Cell & Developmental Biology, presents the MBTP/CSB Seminar: "Mitotic Spindle Assembly in Animal Cells" on Tuesday, June 6, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Elwood Mullins receives VICC AwardCongratulations to Elwood Mullins, of the Eichman Lab, on being named the VICC Postdoctoral Fellow of the Year.
News posted by karen.d.davis@vanderbilt.edu: Marija Zanic presents MBTP/CSB Seminar 05/23/2017Dr. Marija Zanic, Cell & Developmental Biology, presents the RCR Special Session: "Lab Dynamics" on Tuesday, May 23, at 12:30-pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Joe Alvin presents MBTP/CSB Seminar on 5/16/2017Joe Alvin, of the Lacy Lab, presents the MBTP/CSB Seminar: “A Structural Analysis of Glucosyltransferases Domains in Large Clostridial Toxins” on Tuesday, May 16, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Lauren Jackson presents MBTP/CSB Seminar on 5/9/2017Dr. Lauren Jackson, Biological Sciences, presents the MBTP/CSB Seminar: "Molecular mechanisms of coat assembly & regulation in membrane trafficking" on Tuesday, May 9, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Research Spotlight - Brandt EichmanCSB Researcher Brandt Eichman, Ph.D., and colleagues have discovered a structure of a novel DNA glycosylase that can repair DNA cross-links.
News posted by karen.d.davis@vanderbilt.edu: Nicole Perry receives P.E.O. Scholar AwardCongratulations to Nicole Perry, of the Iverson Lab, on receiving a P.E.O. Scholar Award from the P.E.O. Sisterhood, a philanthropic organization based in Des Moines, Iowa. She was sponsored by the P.E.O International Chapter AU in Maryville, Tennessee and is one of 100 doctoral students to receive an award this year.
News posted by karen.d.davis@vanderbilt.edu: Research Spotlight - Teru Nakagawa and Chuck SandersCSB Researcher Teru Nakagawa, Ph.D., has received a two-year Brain and Behavior Research Foundation grant to continue his studies of the molecular keystones of autism and other brain disorders. He is one of 40 scientists to receive 2017 NARSAD Independent Investigator grants from the foundation formerly known as the National Alliance for Research on Schizophrenia and Depression.
News posted by karen.d.davis@vanderbilt.edu: Amanda Duran presents MBTP/CSB Seminar on 5/2/2017Amanda Duran, of the Meiler Lab, presents the MBTP/CSB Seminar: "Computational prediction of membrane protein stability and design" on Tuesday, May 2, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Mona Minkara presents MBTP/CSB Seminar on 4/25/2017Dr. Mona Minkara, University of Minnesota, presents the special MBTP/CSB Seminar: "Molecular Simulation Studies Aiding Drug Design and Delivery" on Tuesday, April 25, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Megan Dumas presents MBTP/CSB Seminar on 4/18/2017Megan Dumas, of the Ryoma Ohi Lab, presents the MBTP/CSB Seminar: "Target Based Screen to Identify Inhibitors of the Mitotic Kinesin Kif15" on Tuesday, April 18, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Ivelin Georgiev presents MBTP/CSB Seminar on 4/4/2017Dr. Ivelin Georgiev, Pathology, Microbiology & Immunology, presents the MBTP/CSB Seminar: "Neutralization fingerprinting analysis of polyclonal antibody responses to HIV-1 infection" on Tuesday, April 4, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Ben Spiller presents MBTP/CSB RCR Seminar on 3/28/2017Dr. Ben Spiller, Pharmacology, presents the RCR Special Session: "When Do Errors Become Fraud?" on Tuesday, March 28, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Brennica Marlow Awarded NSF FellowshipCongratulations to Brennica Marlow, of the Meiler Lab, on receiving a prestigious NSF Graduate Research Fellowship for her research on Cholesterol Membrane Protein Interactions.
News posted by karen.d.davis@vanderbilt.edu: Research Spotlight - Brandt EichmanCSB Researcher Brandt Eichman, Ph.D., has been featured as a “Member Tale” as part of the SBGrid Consortium. Read more about his lab’s work on DNA remodeling done by the replication machinery and damage tolerance proteins as well as the discovery of novel glycosylases in bacteria, which could reveal new genotoxic agents with therapeutic value.
News posted by karen.d.davis@vanderbilt.edu: Ben Spiller presents MBTP/CSB Seminar on 2/7/2017Dr. Ben Spiller, Pharmacology, presents the MBTP/CSB Seminar: "Antibody Neutralization of Influenza H5 and variants" on Tuesday, March 7, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Special Seminar in Structural Biology - 02/14/2017Dr. Stefan Raunser, Max Planck Institute of Moleuclar Physiology, presents the special seminar: "Structural Insights into Tc toxin action" on Tuesday, February 14, at 3:00pm-4:00pm in 1220 MRB3. This Special Seminar in Structural Biology is co-sponsored by Center for Structural Biology and Department of Cell & Developmental Biology. News posted by karen.d.davis@vanderbilt.edu: Carlos Lopez presents MBTP/CSB Seminar on 1/31/2017Dr. Carlos Lopes, Cancer Biology, presents the RCR Special Session: "Why good scientists do bad things" on Tuesday, January 31, at 12:30pm-1:20 pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Norie Sugitani presents Karpay Lecture at MBTP/CSB Seminar on 1/17/2017Congratulations to Norie Sugitani for being named the 2017 recipient of The Karpay Award in Structural Biology. "I am very thankful and honored to receive the Karpay Award," Norie said.
News posted by karen.d.davis@vanderbilt.edu: Terry Lybrand presents the MBTP/CSB Seminar on 1/10/2017Dr. Terry Lybrand, Chemistry, presents the MBTP/CSB SEminar: "Oligonucleotide aptamers for therapeutic and biotechnology applications: Challenges and possibilities" on Tuesday, January 10, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Teru Nakagawa presents MBTP/CSB Seminar on 11/29/2016Dr. Teru Nakagawa, Molecular Physiology & Biophysics, presents the RCR Special Session: "Tips on incorporating new approaches into your research" on Tuesday, November 29, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Research Spotlight: Ray BlindCSB Researcher Ray Blind, Ph.D., has received a two-year V Foundation grant to examine how proteins induce cancerous tumors to grow. The research could enable the development of new therapies for liver cancer patients and help physicians determine which drugs might work best for individual patients.
News posted by karen.d.davis@vanderbilt.edu: Research Spotlight: Chuck SandersCSB Investigator Chuck Sanders, Ph.D., is leading a research team to come up with the first detailed molecular explanation for a factor that may contribute to the so-called cystic fibrosis (CF) “gender gap.”
News posted by karen.d.davis@vanderbilt.edu: Ben Kesler presents MBTP/CSB Seminar on 11/15/2016Ben Kesler, of the Neuert Lab, presents the MBTP/CSB Seminar:"Investigating the Dynamics of X-Chromosome Inactivation in Single Cells" on Tuesday, November 15, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Brandt Eichman presents MBTP/CSB Seminar on 11/1/2016Dr. Brandt Eichman, Biological Sciences, presents the MBTP/CSB Seminar: "Structural adventures in the repair of DNA damage from anti-microbial alkylating agents" on Tuesday, November 1, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Tasia Pyburn presents MBTP/CSB Seminar on 10/18/2016Tasia Pyburn, of the Mel Ohi Lab, presents the MBTP/CSB Seminar: "Structural studies of the Helicobacter pylori pore-forming toxin VacA" on Tuesday, October 18, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: CSB Poster Winner at Personalized Medicine DayCongratulations to Jonathan Sheehan and his team for placing 3rd in the poster presentation at Personalized Medicine Day on Friday, September 23. The team's presentation was titled "Program in Personalized Structural Biology at Vanderbilt University." News posted by karen.d.davis@vanderbilt.edu: Chuck Sanders presents MBTP/CSB Seminar on 9/27/2016Dr. Chuck Sanders, Biochemistry, presents the RCR Special Session: "Navigating Letters of Reference ... By You and About You" on Tuesday, September 27, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Karpay Award in Structural Biology - Call for nominationsThe Karpay Award Committee is now soliciting applications for the 2017 Karpay Award. This award was established in 2010 to commemorate Dr. Anne Karpay, whose studies were focused on membrane protein structural biology under the guidance of Professors Chuck Sanders and Tina Iverson. Her career ended prematurely following a 4-year battle with breast cancer, which claimed her in 2008. Click here to learn more about Dr. Anne Karpay and this award.
News posted by karen.d.davis@vanderbilt.edu: Teru Nakagawa presents MBTP/CSB Seminar on 9/6/2016Dr. Teru Nakagawa, Molecular Physiology & Biophysics, presents the MBTP/CSB Seminar: "Ionotropic glutamate receptors: synaptic function and mechanism of modulation" on Tuesday, September 6, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Stephanie Bamberger presents MBTP/CSB Seminar on 8/16/2016Stephanie Bamberger, of the Stone Lab, presents the seminar: "Characterization of the 2,6-Diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine DNA Lesion" on Tuesday, August 8, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Gregor Neuert presents MBTP/CSB RCR Special Session on 7/26/2016Dr. Gregor Neuert, Molecular Physiology & Biophysics, presents the RCR Special Session: "Data Acquisition and Management" on Tuesday, July 26, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Meredith Frazier presents MBTP/CSB Seminar on 7/19/2016Meredith Frazier, of the Jackson Lab, presents the MBTP/CSB Seminar: "Adaptor protein complex 4 and its binding partner tepsin" on Tuesday, July 19, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Katie Winarski - Dissertation Defense 7/15/2016Katie Winarski, of the Spiller Lab, presents: "Analysis of a Vaccine-Elicited Anti-H5N1 Antibody and its Unmutated Common Ancestor" on Friday, July 15, at 2:00 pm in C2303 MCN. News posted by karen.d.davis@vanderbilt.edu: Jens Meiler presents MBTP/CSB Seminar on 7/5/2016Jens Meiler, Chemistry, presents the MBTP/CSB Seminar: "Computational Design of Antibodies Targeting HIV" on Tuesday, July 5, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Caleigh Azumaya presents MBTP/CSB Seminar on 6/21/2016Caliegh Azumaya, of the Nakagawa Lab, presents the MBTP/CSB Seminar: "AMPAR auxiliary subunit interactions" on Tuesday, June 21, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Lauren Jackson named Pew ScholarCongratulations to CSB faculty member Lauren Jackson on being named a 2016 Pew Scholar by The Pew Charitable Trusts. Lauren received the honor for her work in cell and structural biology the biomedical sciences.
News posted by karen.d.davis@vanderbilt.edu: John York presents MBTP/CSB Seminar on 6/7/2016Dr. John York, Biochemistry Department Chair, presents the MBTP/CSB Seminar: "Inositol Phosphates act as Structural Cofactors to Regulate Biological Processes" on Tuesday, June 7, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Lauren Jackson presents MBTP/CSB Seminar on 5/24/2016Dr. Lauren Parker Jackson, Biological Sciences, presents the RCR Special Session: "Lessons on conduct from consulting and academia, or, 'There, and Back Again'" on Tuesday, May 24, at 12:30pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Eva Harth presents MBTP/CSB Seminar on 5/17/2016Dr. Eva Harth, Chemistry, presents the MBTP/CSB Seminar: "Matrices for the Delivery of Proteins and Small Molecule Therapeutics" on Tuesday, May 17, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Special Seminar hosted by Mchaourab & Meiler Labs on 5/10/2016Dr. Jose Faraldo-Gomez, National Institute of Health, presents the special seminar: "Rationalizing Strict Coupling in Ion-driven Membrane Transport Through Free-Energy Landscapes" on Tuesday, May 10, at 12:00pm-1:00pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Diana Chavez presents MBTP/CSB Seminar on 5/3/2016Diana A. Chavez, of the Eichman Lab, presents the MBTP/CSB Seminar: "Characterization of the HIRAN domain in HLTF DNA Damage Tolerance" on Tuesday, May 3, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Mary Keithly - Dissertation Defense 4/26/2016Mary Keithly, of the Armstrong Lab, presents: "Structure, Substrate Selectivity, and Catalytic Mechanism of the Fosfomycin Resistance Enzyme, FosB, from Gram-Positive Pathogens" on Tuesday, April 26, at 3:00pm in 206 PRB. News posted by karen.d.davis@vanderbilt.edu: Brandt Eichman and Puck Ohi present MBTP/CSB Seminar on 4/26/2016Dr. Brandt Eichman, Biological Sciences, and Dr. Ryoma "Puck" Ohi present the RCR Special Session: "Tips for Navigating Scientific Conferences" on Tuesday, April 26, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Julie Forman-Kay presents MBTP/CSB Seminar 4/19/2016Dr. Julie Forman-Kay, University of Toronto and Hospital for Sick Children, presents the MBTP/CSB Seminar: "Dynamic interactions of disordered proteins in biological regulation and cellular organization" on Tuesday, April 19, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Research Spotlight - Jens MeilerCSB Researcher Jens Meiler, Ph.D., and Vanderbilt colleague James Crowe, Jr., M.D. led a study isolating antibodies that binds tightly to HIV and disables it – even in people not infected by the virus.
News posted by karen.d.davis@vanderbilt.edu: Mike Stone presents MBTP/CSB Seminar on 04/05/2016Dr. Mike Stone, Chemistry, presents the MBTP/CSB Seminar on Tuesday, April 5, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Heidi Hamm presnts MBTP/CSB Seminar on 3/22/2016Dr. Heidi Hamm, Pharmacology, presents the MBTP/CSB Seminar: "Mechanisms of receptor-mediated G protein activation" on Tuesday, March 22, at 12:30pm-1:30pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Catherine Deatherage - Dissertation Defense 3/17/2016Catherine Deatherage, of the Sanders Lab, presents "Comparative Biochemical and Structural Analysis of Alzheimer's Disease Related to Proteins" Thursday, March 17, at 3:00pm in 206 Preston Research Building. News posted by karen.d.davis@vanderbilt.edu: Daniel Putnam - Dissertation Defense 3/17/2016Daniel Putnam, of the Meiler Lab, presents "BCL::SAS - Small Angle X-Ray/Neutron Scattering Profiles to Assist Protein Structure Prediction" Thursday, March 17, at 2:15pm in 512 Light Hall. News posted by karen.d.davis@vanderbilt.edu: Axel Fischer presents MBTP/CSB Seminar on 3/15/2016Axel Fischer, of the Meiler Lab, presents the MBTP/CSB Seminar: "Prediction of protein structure from limited experimental data" on Tuesday, March 15, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Michelle LaFrance - Dissertation Defense 3/7/2016Michelle LaFrance, of the Lacy Lab, presents "Identification of Host Factors Including an Epithelial Cell Receptor Responsible for Clostridium difficile TcdB-Induced Cytotoxity" Monday, March 7, at 2:00 pm in 206 PRB. News posted by karen.d.davis@vanderbilt.edu: Bill Martin presents MBTP/CSB Seminar on 2/23/2016Bill Martin, of the Reiter Lab, presents "ncRNA and Epigenetics: The Regulation of a Histone Demethylase by Structured RNAs" on Tuesday, February 23, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Research Spotlight: Hassane Mchaourab and Jens MeilerCSB Researchers Hassane Mchaourab, Ph.D., Jens Meiler, Ph.D., and colleagues report the dynamics of a drug resistance transporter in Proceedings of the National Academy of Sciences. Antibiotic resistance impedes treatment of bacterial infections, and contributing to this resistance are proteins, such as the Escherichia coli EmrE transporter.
News posted by karen.d.davis@vanderbilt.edu: Irina Kaverina presents MBTP/CSB Seminar on 2/2/2016Dr. Irina Kaverina, Cell & Developmental Biology, presents the MBTP/CSB Seminar: "A new function of Golgi-derived microtubules: revisiting insulin secretion” on Tuesday, February 2, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Melanie Ohi presents MBTP/CSB Seminar on 1/26/2016Dr. Melanie Ohi, Cell & Developmental Biology, presents the RCR Special Session: "Who owns your time?" on Tuesday, January 26, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Karpay Award Recipient Qiuyan Chen presents MBTP/CSB Seminar 1/19/20162016 Karpay Award Winner Qiuyan Chen, of the Iverson & Gurevich labs, presents the MBTP/CSB Seminar: "Arrestin activation? Just press the right buttons" on Tuesday, January 19, at 12:30pm-1:20pm in 1220 MRB3. Reception to follow. News posted by karen.d.davis@vanderbilt.edu: Walter Chazin presents MBTP/CSB Seminar 1/5/2016Dr. Walter Chazin, Director, Molecular Biophysics Training Program, presents the MBTP/CSB Seminar: "Mechanisms of action of RPA and DNA primase in the initiation of genome duplication" on Tuesday, January 5, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Darwin Fu presents MBTP/CSB Seminar 12/15/2015Darwin Fu, Meiler Lab, presents the MBTP/CSB Seminar: "A Murder of Molecules and a Gaggle of GPCRs" on Tuesday, December 15, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Kevin Jagessar presents MBTP/CSB Seminar on 11/17/2015Kevin Jagessar, of the Mchaourab Lab, presents the MBTP/CSB Seminar: "Dynamics of H+/Drug Antiport in an Archaeal MATE Transporter" on Tuesday, November 17, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: CSB Researcher discovers new class of DNA repair enzymeCSB Researcher Brandt Eichman, Ph.D., and colleagues have discovered a new class of DNA repair enzyme. Their findings, reported online in the journal Nature, define a new a new type of DNA glycosylase.
News posted by karen.d.davis@vanderbilt.edu: Jens Meiler wins Bessel Research AwardCongratulations to CSB core faculty member Jens Meiler, Ph.D., on receiving a Friedrich Wilhelm Bessel Research Award from the Humboldt Foundation.
News posted by karen.d.davis@vanderbilt.edu: Jens Meiler presents MBTP/CSB Seminar on 10/27/2015Jens Meiler, Chemistry, presents the RCR Special Session: “Have a nice weekend, see you tomorrow – OR – A Ph.D. is a bridge to wherever you decide to go!" on Tuesday, October 27, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Joe Alvin presents MBTP/CSB Seminar on 10/20/2015Joe Alvin, of the Lacy Lab, presents the MBTP/CSB Seminar: "Structural investigation of C. difficile toxin glucosyltransferases" on Tuesday, October 20, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Qiuyan Chen - Disseration Defense 10/1/2015Qiuyan Chen, Iverson and Gurevich Labs, presents: "Structural Basis of Arrestin Mediated GPCR Signaling" on Thursday, October 1, at 1:00 pm in 206 PRB. News posted by karen.d.davis@vanderbilt.edu: Qiuyan Chen receives Karpay AwardCongratulations to Qiuyan Chen on being named the 2016 recipient of The Anne Karpay Award in Structural Biology. “It is a tremendous honor for me to be chosen as the receipt of this year's Karpay Award,” Qiuyan said.
News posted by karen.d.davis@vanderbilt.edu: Hassane Mchaourab presents MBTP/CSB Seminar on 10/6/15Dr. Hassane Mchaourab, Molecular Physiology & Biophysics, presents the MBTP/CSB Seminar: "Principles of Alternating Access by Active Transporters" on Tuesday, October 6, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Walter Chazin named Biophysical Society FellowCenter for Structural Biology Director Walter Chazin, Ph.D., has been named as a 2016 Society Fellow of the Biophysical Society. The award honors the Society’s distinguished members who have demonstrated sustained scientific excellence.
News posted by karen.d.davis@vanderbilt.edu: Sophia Gayek presents MBTP/CSB Seminar on 8/25/2015Sophia Gayek, of the Puck Ohi Lab, presents the MBTP/CSB Seminar: "The Source of Bipolar Disorders During Mitosis" on Tuesday, August 25, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Laurence Zwiebel presents MBTP/CSB Seminar on 8/18/2015Dr. Laurence Zwiebel, Biological Sciences, presents the RCR Special Session: "An RCR Case Study: Responding to a Questionable Publication" on Tuesday, August 18, at 12:30pm-1:20pm in 1220 MRB3.
News posted by karen.d.davis@vanderbilt.edu: Chuck Sanders named interim journal editorCSB Investigator Chuck Sanders, Ph.D., has been named interim editor of the journal Biochemistry. His appointment follows the death of CSB colleague Richard Armstrong, Ph.D., professor of Biochemistry and Chemistry, who had served as the journal’s editor-in-chief since 2004.
News posted by karen.d.davis@vanderbilt.edu: Anne Kenworthy presents MBTP/CSB Seminar on 8/4/2015Dr. Anne Kenworthy, Molecular Physiology & Biophysics, presents the MBTP/CSB Seminar: "Impact of novel disease-associated mutations on caveolae assembly and function" on Tuesday, August 4, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Research Spotlight - Stephen FesikCSB Researcher Stephen Fesik, Ph.D., was recently highlighted in ACS Chemical Research in Toxicology for his research involving the antiapoptotic protein myeloid cell leukemia-1 (Mcl-1).
News posted by karen.d.davis@vanderbilt.edu: Research Spotlight - Brandt EichmanCSB Researcher Brandt Eichman, Ph.D., and graduate student Diana Chavez, working in collaboration with a research team at Stanford University, have discovered how the protein HLTF (helicase-like transcription factor) recognizes and remodels stalled replication “forks.” Their findings, published in Molecular Cell, shed light on processes that help cells tolerate DNA damage and have implications for cancer therapies that target DNA replication and repair.
News posted by karen.d.davis@vanderbilt.edu: Catherine Deatherage wins Cunningham AwardCongratulations to Catherine Deatherage, of the Sanders Lab, on winning the 2015 Leon W. Cunningham Award for Excellence in Biochemistry. Catherine presented “C99, and GSAP, and Notch, Oh My!: Structural and Biophysical Characterization of Alzheimer's Disease Related Proteins” as part of the award presentation on June 10.
News posted by karen.d.davis@vanderbilt.edu: Marilyn Holt presents MBTP/CSB Seminar on 7/21/2015Marilyn Holt, of the Chazin Lab, presents the MBTP/CSB Seminar: "Cracking the Case of a Molecular Calculator: Primase and DNA Charge Transport" on Tuesday, July 21, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Kate Mittendorf - Dissertation Defense 7/8/2015Kate Mittendorf, of the Sanders Lab, presents "The Interactions of Two Disease-Linked Membrane Proteins with Their Bilayer Milieu" on Wednesday, July 8, at 1:00 pm in 206 PRB. News posted by karen.d.davis@vanderbilt.edu: Dylan Burnette presents MBTP/CSB Seminar on 6/30/2015Dr. Dylan Burnette, Cell & Developmental Biology, presents the RCR Special Session:"TO CATCH A FORGER: Practical Methods for Detecting Scientific Image Manipulation" on Tuesday, June 30, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Karpay Award: Call for ApplicationsWe are now accepting applications for the 2016 Karpay Award. As a reminder to the molecular biophysics community, the Karpay Award was established in 2010 in the memory of Dr. Anne Karpay and recognizes one senior graduate student each year in the area of structural biology (broadly defined). A $1500 honorarium accompanies the award, which is contingent upon the winner giving the first MBTP seminar in January when the award will be presented. Please visit the Karpay Award webpage to learn more about Dr. Anne Karpay and this award.
News posted by karen.d.davis@vanderbilt.edu: Passing of Richard ArmstrongBelow you can find the formal announcement from the Department of Biochemistry of the passing of our colleague Richard Armstrong earlier this week. The CSB, of which Richard was a Core Faculty member, joins the Department in mourning the loss of our colleague.
News posted by karen.d.davis@vanderbilt.edu: Aidan Fenix presents MBTP/CSB Seminar on 6/16/2015Aidan Fenix, of the Burnette Lab, presents the MBTP/CSB Seminar: "Expansion of non-muscle myosin II filaments drives cellular contractile system formation in interphase and mitosis" on Tuesday, June 16, at 12:30pm-1:20pm in 1220 MRB3. News posted by stephen.m.doster@Vanderbilt.Edu: CSB Research Spotlight - Jens MeilerJames Crowe Jr., Ph.D., and CSB Researcher and Chancellor Faculty Fellow Jens Meiler, Ph.D., recently reported findings in the Journal of Clinical Investigation which suggest that computer-redesigned antibodies may speed the search for an effective therapy or vaccine for a virus that so far has eluded all attempts to eradicate it. With the help of a computer program called “Rosetta,” the researchers have “redesigned” an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency virus (HIV) than can any known natural antibody. Visit Research News@Vanderbilt for the full story.
News posted by stephen.m.doster@Vanderbilt.Edu: CSB Research Spotlight - Borden LacyCSB Researcher and Chancellor Faculty Fellow Borden Lacy and colleagues have identified a cellular receptor for a toxin from Clostridium difficile (C. diff).
News posted by karen.d.davis@vanderbilt.edu: Teru Nakagawa presents MBTP/CSB Seminar on 6/2/2015Dr. Teru Nakagawa, Molecular Physiology & Biophysics, presents "AMPA receptors and their complexes" on Tuesday, June 2, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Drew Kellum presents MBTP/CSB Seminar on 5/19/2015Drew Kellum, of the Stone Lab, presents MBTP/CSB Seminar: "Probing the Conformational and Configurational Equilbria of 2’-Deoxyribosylurea Lesions within Single Strand and Duplex DNA" on Tuesday, May 19, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Samuel DeLuca - Dissertation Defense 5/6/2015Samuel DeLuca, of the Meiler Lab, presents: "Development of Novel Methods for Computational Protein Design and Protein-Ligand Docking" on Wednesday, May 5, at 2:30 pm in 208 Light Hall. News posted by stephen.m.doster@vanderbilt.edu: CSB Postdoc exhibits technology entrepreneurshipCongratulations to Michael Feldkamp, postdoc in the Chazin Lab, on being a member of the 2015 TechVenture Challenge’s winning team. The TechVenture Challenge is an educational event that allows students to learn the process of commercializing early technologies and showcases emerging intellectual property from Vanderbilt University. “First Diagnostics,” Feldkamp’s team, presented Corafix (fluorocoxib A), a fluorescently labeled selective inhibitor of the COX-2 enzyme developed by Vanderbilt investigators.
News posted by karen.d.davis@vanderbilt.edu: Paul Bock presents MBTP/CSB Seminar on 4/5/2015Dr. Paul Bock, Pathology, presents the MBTP/CSB Seminar: "Pathogen Activators of Plasminogen: invisible parts of the mechanism of plasminogen activation by streptokinase" on Tuesday, May 5, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Victoria D'Souza presents MBTP/CSB Seminar on 4/28/2015Student invited speaker Dr. Victoria D'Souza, Harvard University, presents the MBTP/CSB Seminar: "Unraveling viral RNA genomes: One segment at a time" on Tuesday, April 28, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Carl Johnson presents MBTP/CSB Seminar on 4/7/2015Dr. Carl Johnson, Biological Sciences, presents the MBTP/CSB Seminar: "Molecular Gears and Cogs of a Circadian Clockwork" on Tuesday, April 7, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Hassane Mchaourab presents MBTP/CSB Seminar on 3/31/2015Dr. Hassane Mchaourab, Molecular Physiology & Biophysics, presents the RCR Special Session: "Is a Ph.D. a bridge to nowhere?" on Tuesday, March 31, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: SAXS Workshop 03/23/2014Dr. Greg Hura, Lawrence Berkeley National Laboratory, and the Center for Structural Biology will host a Small Angle X-ray Scattering (SAXS) workshop on Monday, March 23, at 1:00pm-4:00pm in 5131 MRB3.
News posted by karen.d.davis@vanderbilt.edu: Greg Hura presents MBTP/CSB Seminar on 3/24/2015Dr. Greg Hura, Lawrence Berkeley National Laboratory, presents the MBTP/CSB Seminar: "Combining SAXS and Crystallography to build intuition in interaction networks and macromolecular engineering" on Tuesday, March 24, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Nicole Chumbler - Dissertation Defense 3/12/2015Nicole Chumbler, of the Lacy Lab, presents: "Defining the Functions and Regulation of Clostridium difficile Toxins A and B Enzymatic Activities in Cellular Intoxication" on Thursday, March 12, at 3:00 pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: The Protein Society Annual Meeting - July 22-25The 29th Annual Symposium of the Protein Society will be held July 22-25 in Barcelona, Spain. The meeting features prestigious speakers, numerous workshops and networking opportunities set against the architectural and cultural backdrop of Barcelona.
News posted by karen.d.davis@vanderbilt.edu: Nick Reiter presents MBTP/CSB Seminar on 3/3/2015Dr. Nick Reiter, Biochemistry, presents the MBTP/CSB Seminar: "RNA-protein communications: From tRNA processing to the chromatin interface" on Tuesday, March 3, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Rescheduled: Marilyn Holt presents MBTP/CSB Seminar on 2/24/2015Please note this seminar was originally scheduled for February 17, but was cancelled due to inclement weather.
News posted by karen.d.davis@vanderbilt.edu: Borden Lacy and Jens Meiler named Inaugural Chancellor Faculty FellowsCongratulations to CSB core faculty members Borden Lacy, Ph.D., and Jens Meiler, Ph.D., for being selected as part of the first cohort of the Chancellor Faculty Fellows Program.
News posted by karen.d.davis@vanderbilt.edu: Marilyn Holt presents MBTP/CSB Seminar on 2/17/2015Marilyn Holt, of the Chazin Lab, presents the RCR Special Session: "Oops, I did it again: Retractions and misconduct in the scientific literature" on Tuesday, February 17, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Mel Ohi presents VICB Seminar on 2/11/2015Mel Ohi, Cell & Developmental Biology, presents the VICB Seminar: "Studying the Molecular Function of Dynamic Molecular Machines" on Wednesday, February 11, at 12:15pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Structural Biology Symposium - March 6-7, 2015You are invited a special symposium honoring the contributions of Prof. Walter Chazin in his scientific career thus far and in honor of his 60th birthday this year.
News posted by karen.d.davis@vanderbilt.edu: Sten Heinze - Dissertation Defense 2/18/2015Sten Heinze, of the Meiler Lab, presents: "Improvements for BCL::Fold de novo protein structure prediction" on Wednesday, February 18, at 12:00pm in 5502 Stevenson Center. News posted by karen.d.davis@vanderbilt.edu: Clare McCabe presents MBTP/CSB Seminar on 2/10/2015Dr. Clare McCabe, Chemical and Biomolecular Engineering, presents the MBTP/CSB Seminar: "Understanding the Self-Assembly of Skin Lipids" on Tuesday, February 10, at 12:30pm-1:20pm in 1220 MRB3. News posted by karen.d.davis@vanderbilt.edu: Jonathan Sachs presents Chemistry Colloquium Series on 2/2/2015Professor Jonathan Sachs, University of Minnesota, presents the Chemistry Colloquium Seminar: "Understanding the chemistry and appreciating the importance of methionine-aromatic interactions in protein structure and function" on Monday, February 2, at 4:15pm-5:30pm in 5211 Stevenson Center. Refreshments will be served at 4:00pm in the seminar room.
News posted by karen.d.davis@vanderbilt.edu: Fesik Lab forms multi-year alliance to develop cancer treatmentVanderbilt University and Boehringer Ingelheim have established a multi-year alliance to research and develop small molecule inhibitors of oncogenic Ras for cancer treatment. CSB Investigator Stephen Fesik, Ph.D., will lead the research of new medicines for the Ras protein family at Vanderbilt. The alliance aim is to combine the techniques and expertise of the Fesik Lab and Boehringer Ingelheim to address what has been a difficult drug to target.
News posted by karen.d.davis@vanderbilt.edu: Qi Sun - Dissertation Defense 1/15/2015Qi Sun, of the Fesik Lab, presents "Discovery of K-Ras Inhibitors for the Treatment of Cancer" on Thursday, January 15, in 214 Light Hall at 3:00 pm. News posted by karen.d.davis@vanderbilt.edu: Bock research honored by Journal of Biological ChemistryCSB Investigator Paul Bock and his Vanderbilt colleague Ingrid Verhamme have been honored by the Journal of Biological Chemistry. Their paper, Rapid binding of plasminogen to streptokinase in a catalytic complex reveals a three-step mechanism has been designated as one of the best papers published by the JBC in 2014.
News posted by karen.d.davis@vanderbilt.edu: Chuck Sanders presents MBTP/CSB Seminar on 1/6/2015Chuck Sanders, Ph.D., presents the MBTP/CSB Seminar: "Why Protein Stability Matters to Personalized Medicine" on Tuesday, January 6, at 12:30pm-1:20pm in 1220 MRBIII. News posted by stephen.m.doster@vanderbilt.edu: Research Spotlight - Ben SpillerCSB member Ben Spiller and Tara Archuleta, Ph.D., (of the Jackson Lab) were featured in the Aliquots section of the VUMC Reporter.
News posted by karen.d.davis@vanderbilt.edu: Eric DawsonIt is with great sadness that I pass along the message that our colleague Eric Dawson, who was an integral part of our community and served a key role in the CSB Computation Education & Outreach program for many years, has passed away.
News posted by karen.d.davis@vanderbilt.edu: Kallie Stavros presents MBTP/CSB Seminar on 12/9/2014Kallie Stavros, of the Stone Lab, presents the MBTP/CSB Seminar: "Understanding the sequence dependence of the food mutagen 2-methyl-3-amino-[4,5-f]imidazoquinoline in the NarI recognition sequence" on Tuesday, December 9, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Shane Hutson presents MBTP/CSB Seminar on 12/2/2014Shane Hutson, Ph.D., presents the MBTP/CSB Seminar: "From non-specific environmental stresses to adverse developmental outcomes: the role of cellular mechanics" on Tuesday, December 2, at 12:30-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Catherine Deatherage presents MBTP/CSB Seminar on 11/18/2014Catherine Deatherage, of the Sanders Lab, presents the MBTP/CSB Seminar: "Notch your average membrane protein" on Tuesday, November 18, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Vittorio Luzzati presents VICB Seminar on 11/5/2014Renowned X-ray crystallographer Dr. Vittorio Luzzati presents the VICB Seminar: "Souvenirs of a Paleo-Protein-Crystallographer" on Wednesday, November 5, at 12:15pm-1:15pm in 1220 MRBIII.
News posted by karen.d.davis@vanderbilt.edu: Borden Lacy presents MBTP/CSB Seminar on 11/4/2014Borden Lacy, Ph.D., presents the MBTP/CSB Seminar: "Structural analysis of the Clostridium difficile Toxins" on Tuesday, November 4, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: CSB Research Spotlight - Hassane MchaourabCSB researcher Hassane Mchaourab, Ph.D., and his research team have been featured in the VUMC Reporter for their new view of transporter dynamics.
News posted by karen.d.davis@vanderbilt.edu: Steven Combs presents MBTP/CSB Seminar on 10/28/2014Steven Combs, Ph.D., presents the RCR Special Session: "Health and life expectancy disparity in rich and poor nations" on Tuesday, October 28, at 12:30pm - 1:20 pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Kendra Vann presents MBTP/CSB Seminar on 10/21/2014Kendra Vann, of the Osheroff Lab, presents the MBTP/CSB Seminar: "Metabolites of olive leaf plants as covalent topoisomerase II poisons" on Tuesday, October 21, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: 2014 Vanderbilt Translational Research ForumThe Office for Clinical & Translational Scientist Development is sponsoring the 2014 Vanderbilt Translational Research Forum on November 7 in Sarratt Cinema on the Vanderbilt University Campus.
News posted by karen.d.davis@vanderbilt.edu: Kate Mittendorf wins Karpay AwardCongratulations to Kate Mittendorf for being named the 2015 recipient of The Anne Karpay Award in Structural Biology. "I am honored and humbled to have been selected as the recipient of the Karpay Award," Kate said.
News posted by karen.d.davis@vanderbilt.edu: Manuel Ascano presents MBTP/CSB Seminar on 10/7/2014Manuel Ascano, Ph.D., presents the MBTP/CSB Seminar: "The roles of nucleic acid binding proteins in post-transcriptional gene regulation and innate immunity" on Tuesday, October 7, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Ben Spiller presents MBTP/CSB Seminar on 9/30/2014Ben Spiller, Ph.D., presents the RCR Special Session: "Avoiding the pitfalls of single particle cryo-electron microscopy: Einstein from noise, and associated RCR considerations" on Tuesday, September 30, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Norie Sugitani presents MBTP/CSB Seminar on 9/46/2014Norie Sugitani, of the Chazin Lab, presents the MBTP/CSB Seminar: "Progress Towards the Investigation of XPA-DNA Interaction in Human Nucleotide Excision Repair (NER)" on Tuesday, September 16, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: New members appointed to the CSB Core FacultyCarlos Lopez, Ph.D., of the Department of Cancer Biology and Jamaine Davis, Ph.D., of the Department of Biochemistry and Cancer Biology at Meharry Medical College were appointed to the CSB Core Faculty.
News posted by karen.d.davis@vanderbilt.edu: Dylan Burnette presents MBTP/CSB Seminar on 9/9/2014Dylan Burnette, Ph.D., presents the MBTP/CSB Seminar: "Exploring how cells obtain their shapes with super-resolution microscopy" on Tuesday, September 9, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Sanjay Mishra presents the MBTP/CSB Seminar on 8/26/2014Sanjay Mishra, of the Mchaourab Lab, presents the MBTP/CSB Seminar:"Role of Sequence Divergence in Tuning of the Chaperone Activity of a Small Heat Shock Protein" on Tuesday, August 26, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Stephanie DeLuca - Dissertation Defense 8/19/2014Stephanie DeLuca, of the Meiler Lab, presents "Protein Structure Elucidation by Combining Computational and Experimental Methods" on Tuesday, August 19, in 1220 MRBIII at 1:30 pm. News posted by karen.d.davis@vanderbilt.edu: Teru Nakagawa and Darwin Fu present MBTP/CSB Seminar on 8/19/2014Teru Nakagawa, Ph.D., and Darwin Fu, of the Meiler Lab, present the RCR Special Session: "Science for all? Open Access in Today’s Research" on Tuesday, August 19, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Chuck Sanders elected to The Protein Society's Executive CouncilCongratulations to Chuck Sanders, Ph.D., on being elected to the Executive Council of The Protein Society. He will serve a three-year term. News posted by karen.d.davis@vanderbilt.edu: Kevin Schey presents MBTP/CSB Seminar on 8/12/2014Kevin Schey, Ph.D., presents the MBTP/CSB Seminar: "Proteomics of Integral Membrane Proteins: Insights into Structure and Function of Channels and Transporters" on Tuesday, August 12, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Yuanli Song presents MBTP/CSB Seminar on 7/22/2014Sanders Lab member Yuanli Song, Ph.D., presents the MBTP/CSB Seminar: "Discovery of Compounds that Interrupt the Binding of Cholesterol and the Amyloid Precursor Protein of Alzheimer's Disease" on Tuesday, July 22, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: James Crowe presents MBTP/CSB Seminar on 7/8/2014James Crowe, M.D., presents the MBTP/CSB Seminar: Genetic and Structural Determinants of Virus Neutralization by Human Antibodies" on Tuesday, July 8, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Chrystal Starbird presents MBTP/CSB Seminar on 6/17/2014Chrystal Starbird, of the Iverson Lab, presents the MBTP/CSB Seminar: "Complex II becomes more complex: Investigating new roles and new assembly factors for Complex II" on Tuesday, June 17, at 12:30pm-1:30pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Mike Stone presents MBTP/CSB Seminar on 6/10/2014Mike Stone, Ph.D., presents the RCR Special Session: "Who is Paying for Life in the Ivory Tower of American Academia and What [If Anything] Do Academicians Owe to Them?" on Tuesday, June 10, at 12:30pm-1:20pm in 1220 MRBIII. News posted by stephen.m.doster@vanderbilt.edu: CSB Research Spotlight: Brandt EichmanThe journal Proceedings of the National Academy of Sciences recently published studies by CSB member Brandt Eichman and his colleagues that uncovered a conserved recognition domain in DNA repair enzymes. This domain couples DNA recognition and remodeling and plays an important role in stabilizing replication forks and maintaining genome integrity. The researchers demonstrated that the HARP domain is a functional substitute for one of these regions and that mutations of predicted DNA-binding amino acids in the HARP domain reduced its ability to bind to replication forks and facilitate repair. The Eichman Lab is focused on understanding how proteins recognize and manipulate DNA structure to carry out various biological processes.
News posted by karen.d.davis@vanderbilt.edu: Borden Lacy to give Flexner Discovery Lecture on 5/22/2014CSB investigator Borden Lacy, Ph.D., is among the presenters to give the Flexner Discovery Lecture on Thursday, May 22, at 4:00pm in 208 Light Hall.
4:00pm Dr. Lacy’s presentationThe Flexner Discover Lecture Series is sponsored by the Office of the Vice Chancellor for Health Affairs. Please visit the Lecture Series website for more information regarding prior lectures, featured speaker and upcoming speakers. News posted by stephen.m.doster@vanderbilt.edu: CSB Research Spotlight - Martin EgliThe VUMC Reporter recently featured Martin Egli, Professor of Biochemistry, in Aliqouts for his “Paper of the Week” published online April 23 by the Journal of Biological Chemistry.
News posted by karen.d.davis@vanderbilt.edu: Kathleen Mittendorf presents MBTP/CSB Seminar on 5/20/2014Kathleen Mittendorf, of the Sanders Lab, presents the MBTP/CSB Seminar: "Biochemical and Electron Microscopy Studies of a Membrane-Organizing Tetraspan Protein" on Tuesday, May 20, at 12:30pm-1:20pm in 1220 MRBIII. News posted by stephen.m.doster@vanderbilt.edu: Gerald Stubbs among those honored as emeriti facultyGerald S. Stubbs, CSB investigator and professor of biological sciences, now has a new title – “emeritus”! This latest honor was bestowed on Dr. Stubbs and nineteen retiring faculty members during Vanderbilt’s Commencement ceremony on May 9th.
News posted by stephen.m.doster@vanderbilt.edu: Hassane Mchaourab named to endowed chairHassane S. Mchaourab, Ph.D., CSB investigator and professor of molecular physiology and biophysics, is one of eleven Vanderbilt University faculty members recently named to endowed chairs. He has been named to the Louise B. McGavock Chair.
News posted by karen.d.davis@vanderbilt.edu: Irina Kaverina presents MBTP/CSB Seminar on 4/29/2014Irina Kaverina, Ph.D., presents the RCR Special Session: "Digital image processing and quantification: making your point, avoiding bias" on Tuesday, April 29, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Sonja Brooks - Dissertation Defense 4/22/2014Sonja Brooks, of the Eichman Lab, presents "Biochemical Characterization of the DNA Glycosylase DEMETER" on Tuesday, April 22, at 2:00 pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Katie Winarski presents the MBTP/CSB Seminar on 4/15/2014Katie Winaski, of the Spiller Lab, presents the MBTP/CSB Seminar: "Structure of the anti-influenza antibody H5.3 and influenza glycoprotein hemagglutinin 5 reveals an induced fit binding mechanism" on Tuesday, April 15, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Now Accepting Applications for L'Oreal USA For Women in Science Fellowship ProgramThe L'Oreal For Women in Science program recognizes and rewards the contributions women make in the STEM fields and identifies exceptional women researchers committed to serving as role models for younger generations. More than 2,000 women scientists in over 100 countries have been recognized since the program began in 1998.
News posted by karen.d.davis@vanderbilt.edu: Joshua Eggold named 2014 Goldwater winnerJoshua Eggold, undergraduate student in the Chazin Lab, is one of three Vanderbilt students selected as a Goldwater Scholar. This year, 232 scholars were selected on the basis of academic merit from a field of 1,166 mathematics, science and engineering students nominated by colleges and universities nationwide.
News posted by karen.d.davis@vanderbilt.edu: Terry Lybrand presents MBTP/CSB Seminar on 4/1/2014Terry Lybrand, Ph.D., presents the MBTP/CSB Seminar: "The 2013 Chemistry Nobel Prize: Is quantum mechanics really that important in molecular biophysics?" on Tuesday, April 1, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Workshop on Neutron Scattering Applications in Structural Biology held at ORNLThe workshop on Neutron Scattering Applications in Structural Biology aims at enabling structural biologists to fully exploit the latest instrumentation and software development at the SNS and HFIR facilities at Oak Ridge National Laboratory. Attendees will participate in lectures and tutorials focusing exclusively on neutron techniques applied in structural biology. The workshop is designed for graduate students, post-doctoral fellows and faculty new to or with limited experience in neutron scattering. The registration deadline is April 18.
News posted by karen.d.davis@vanderbilt.edu: Tanja Mittag to present Biochemistry SeminarTanja Mittag, from St. Jude Children's Research Hospital, presents the Frontiers in Biochemistry Seminar at noon on Friday, March 28 in 202 LH.
News posted by stephen.m.doster@vanderbilt.edu: CSB Research Spotlight - Stephen FesikBecause of its role in cell growth and survival, aberrant Ras signaling can contribute to carcinogenesis. Mutations in RAS genes are among the most common in malignant tumors, present in up to 30% of human cancers. Consequently, inhibitors of excessive Ras signaling are of great interest as potential cancer chemotherapeutic agents. However, attempts to discover small molecules that bind to Ras proteins and interfere with their function have been met with limited success due to the lack of binding pockets on the protein.
News posted by karen.d.davis@vanderbilt.edu: Scott Collier presents MBTP/CSB Seminar on 3/18/2014Scott Collier, of the Mel Ohi Lab, presents the MBTP/CSB Seminar: "Characterizing the Structure and Function of the N-terminus of S. Pombe Cdc5" on Tuesday, March 18, at 12:20pm-1:20pm in 1220 MRBIII. News posted by stephen.m.doster@Vanderbilt.Edu: CSB Research Spotlight - Richard ArmstrongRichard Armstrong, Ph.D., professor of Biochemistry, was featured in the February 28 issue of the VUMC Reporter for characterizing how methicillin-resistant Staphylococcus aureus (MRSA) resists the antibiotic fosfomycin. S. aureus contains antibiotic-modifying enzymes that facilitate resistance to a number of antimicrobial compounds.
News posted by karen.d.davis@vanderbilt.edu: Mel Ohi promoted to Associate Professor with tenureMelanie Ohi, Ph.D., has been promoted Associate Professor with tenure effective March 14. Congratulations Mel! News posted by karen.d.davis@vanderbilt.edu: Microscopy Open House 3/6/2014Leica Microsystems is holding a "Microscopy Open House" for working with protein crystals. The open house is Thursday, March 6, from 10 am until 4 pm in room U5202 Biological Sciences/MRB III.
News posted by karen.d.davis@vanderbilt.edu: Galina Lepesheva presents MBTP/CSB Seminar on 03/04/2013Galina Lepesheva, Ph.D., presents the MBTP/CSB Seminar: "CYP51 structure/function in drug discovery" on Tuesday, March 4, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: William Wan - Dissertation Defense 03/07/2014William Wan, of the Stubbs Lab, presents "Structure and Assembly of the Fungal Prion-Forming Domain HET-s (218-289)" on Friday, March 7, at 1:30 pm in 206 PRB. News posted by karen.d.davis@vanderbilt.edu: Early Registration Deadline for BSDF Membrane Proteins Symposium is March 1The Biomolecular Structure, Dynamics, and Function: Membrane Proteins Symposium is scheduled for May 2-4, 2014 at the Vanderbilt Commons Center. The early registration deadline March 1, 2014. The BSDF Organizing Committee encourages early registration because conference participation is limited.
News posted by karen.d.davis@vanderbilt.edu: Marta Szulik presents MBTP/CSB Seminar on 2/25/2014Marta Szulik, of the Stone Lab, presents the MBTP/CSB Seminar: "Oxidation products of 5-methylcytosine in DNA" on Tuesday, February 25, at 12:30pm-1:30pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Chuck Sanders presents MBTP/CSB Seminar RCR Special Session on 2/11/2014Chuck Sanders, Ph.D., presents the RCR Special Session: "Case Studies in Actions Leading to Professional Regret" on Tuesday, February 11, at 12:30pm - 1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Lauren Jackson presents MBTP/CSB Seminar on 2/4/2014Lauren Jackson, Ph.D., presents the MBTP/CSB Seminar: "Molecular mechanisms of vesicle coat assembly in membrane trafficking" on Tuesday, February 4, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Nicole Chumbler presents MBTP/CSB Seminar on 1/21/20142014 Karpay Award Winner Nicole Chumbler, of the Lacy Lab, presents the MBTP/CSB Seminar: "Who's the boss? Structural investigations of Clostridium difficile Toxin A autoprocessing" on Tuesday, January 21, at 12:30pm-1:20pm in 1220 MRBIII. Reception to follow. News posted by karen.d.davis@vanderbilt.edu: Matthew Tyska presents MBTP/CSB seminar on 01/14/2014Matthew Tyska, Ph.D., presents the MBTP/CSB Seminar: "Shaping the cell surface with adhesion molecules" on Tuesday, January 14, at 12:30pm-1:20pm in 1220 MRBIII. News posted by stephen.m.doster@vanderbilt.edu: Vanderbilt - Belgian team lay groundwork for preventing multidrug resistanceIn a recently published paper by Nature Chemical Biology, Hassane Mchaourab, Ph.D., and his colleagues report their findings on LmrP, a multidrug transporter from Lactococcus lactis, and its role in antibiotic resistance. Multidrug transporters are notable for their ability to recognize a wide range of molecules with diverse structures and transport them out of the cell. The researchers used Double Electron-Electron Resonance (DEER) spectroscopy to investigate how protons and ligands shift the equilibrium of LmrP to pump out anticancer drugs, antibiotics, and other drugs. Understanding this mechanism gives researchers a starting point for new approaches to block multidrug transporter function in order to combat the growing problem of bacterial multidrug resistance.
News posted by karen.d.davis@vanderbilt.edu: Dave Piston presents MBTP/CSB Seminar on 1/7/2014David Piston, Ph.D., presents the MBTP/CSB Seminar: "Molecular Communication Underlying Hormone Secretion" on Tuesday, January 4, at 12:30 - 1:20 pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Amicia Elliott presents MBTP/CSB Seminar on 12/17/2013Amicia Elliott, of the Piston Lab, presents the MBTP/CSB Seminar: "Imaging Live Cell Dynamics using Snapshot Hyperspectral Image Mapping Spectrometry” on Tuesday, December 17, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Carlos Lopez presents MBTP/CSB Seminar on 12/10/2013Carlos Lopez, Ph.D., presents the MBTP/CSB Seminar: "How cells commit to apoptotic or necrotic cell-death" on Tuesday, December 10, at 12:30-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Paul Bock elected AAAS fellowCenter for Structural Biology faculty member Paul Bock, Ph.D., has been elected fellow of the American Association for the Advancement of Science (AAAS).
News posted by karen.d.davis@vanderbilt.edu: Gregor Neuert presents MBTP/CSB Seminar on 12/3/2013Gregor Neuert, Ph.D., presents the RCR Special Session: "Data Acquisition and Management" on Tuesday, December 3, at 12:30pm - 1:20 pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Sonja Brooks presents MBTP/CSB Seminar on 11/19/2013Sonja Brooks, of the Eichman Lab, presents the MBTP/CSB Seminar "Excision of 5-methylcytosine and its oxidation derivatives by the DEMETER glycosylase family" on Tuesday, November 19, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Kelli Kazmier - Dissertation DefenseKelli Kazmier, of the Mchaourab and Meiler Labs, presents "Revealing the mechanistic diversity of the LeuT Fold Structural Superfamily: A comparative analysis of the Leucine Transporter and the Hydantoin Transporter using Electron Paramagnetic Resonance spectroscopy" on Friday, November 15, in 202 Light Hall at 12:00 pm. News posted by karen.d.davis@vanderbilt.edu: New CSB Faculty Member - Lauren JacksonPlease welcome Lauren Jackson, Ph.D., as the newest faculty member of the Department of Biological Sciences. Jackson joins the Vanderbilt community in January and will teach classes as well as contribute to the major biochemistry courses. She will also work under the umbrella of the Center for Structural Biology.
News posted by karen.d.davis@vanderbilt.edu: CSB Research Spotlight - Borden LacyCSB researcher Borden Lacy, Ph.D., and colleagues have been featured in the VUMC Reporter for their recent findings on Clostridium difficile (“C. difficile”) infection which is a leading cause of hospital-associated diarrhea.
News posted by karen.d.davis@vanderbilt.edu: Leipzig professor Martin von Bergen presents MBTP/CSB Seminar on 11/5/2013Guest speaker Professor Martin von Bergen, of Leipzig University, presents the MBTP/CSB Seminar: "Signaling in proteomics and the neglected majority" on Tuesday, November 5, at 12:30pm-1:20pm in MRBIII, Room 1220.
News posted by karen.d.davis@vanderbilt.edu: Christopher Johnson presents MBTP/CSB Seminar on 10/15/2013Christopher Johnson, Ph.D., of the Chazin Lab, presents the MBTP/CSB Seminar: "A Cardiac Channel, Calcium Regulation, and Calmodulin Mutations" on Tuesday, October 15, at 12:30pm - 1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Nicole Chumbler receives Karpay AwardCongratulations to Nicole Chumbler for being named the 2014 recipient of The Anne Karpay Award in Structural Biology. “I am very honored to have been selected as the recipient of the Karpay Award,” Nicole said.
News posted by karen.d.davis@vanderbilt.edu: Melanie Ohi presents MBTP/CSB Seminar on 10/8/2013Melanie Ohi, Ph.D., presents the RCR Special Session: "Dealing with disagreements" on Tuesday, October 8, at 12:30pm - 1:30pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Jens Meiler presents MBTP/CSB Seminar on 10/1/2013Jens Meiler, Ph.D., presents "Membrane proteins structure determination from limited experimental data" on Tuesday, October 1, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Richard Armstrong receives Arthur C. Cope Scholar AwardCongratulations to CSB researcher Richard Armstrong, Ph.D., on being selected to receive a 2014 Arthur C. Cope Scholar Award from the American Chemical Society.
News posted by karen.d.davis@vanderbilt.edu: Steven Combs presents MBTP/CSB Seminar on 9/17/2013Steven Combs, of the Meiler Lab, presents the MBTP/CSB Seminar: "Scientific advances from massive multiplayer games" on Tuesday, September 17, at 12:20pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Chuck Sanders Named to Endowed ChairCongratulations to CSB researcher Chuck Sanders, Ph.D., for being named the Aileen M. Lange and Annie Mary Lyle Chair in Cardiovascular Research.
News posted by karen.d.davis@vanderbilt.edu: Paul Barrett - Dissertation Defense 9/5/2013Paul Barrett, of the Sanders Lab, presents "Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-terminal Fragment C99 and the Etiology of Alzheimer's Disease" on Thursday, September 5, at 1:00pm in 206 PRB. News posted by karen.d.davis@vanderbilt.edu: Anne Kenworthy presents the MBTP/CSB "RCR Special Session" Seminar on 8/27/2013Anne Kenworthy, Ph.D., presents the RCR Special Session: "Making collaborations work" on Tuesday, August 27, 2013 at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Steven Combs - Dissertation Defense 8/16/2013Steven Combs, of the Meiler Lab, presents "Identification and Scoring of Partial Covalent Interactions in Proteins and Protein Ligand Complexes" on Friday, August 16, in Medical Center North, Room C-2209 at 2:00pm. News posted by karen.d.davis@vanderbilt.edu: Tara Archuleta presents MBTP/CSB Seminar on 8/20/2013Tara Archuleta, of the Spiller Lab, presents the MBTP/CSB Seminar: "From plug to effector: A biochemical analysis of the multifaceted Chlamydial protein, CopN" on Tuesday, August 20, at 12:30-1:20 pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Irina Kaverina presents MBTP/CSB Seminar on 8/6/2013Irina Kaverina, Ph.D., presents the MBTP/CSB Seminar: "Regulation and Functions of Golgi-derived Microtubules" on Tuesday, August 6, at 12:30pm-1:20pm in 1220 MRBIII. News posted by brandt.eichman@vanderbilt.edu: Borden Lacy receives Early Career AwardCongratulations to Dr. Borden Lacy for receiving the
2014 Margaret C. Etter Early Career Award from the
American Crystallographic Association. The award
recognizes "outstanding achievement and exceptional
potential in crystallographic research demonstrated
by a scientist at an early stage of their
independent career."
News posted by karen.d.davis@vanderbilt.edu: Paul Barrett wins Cunningham AwardCongratulations to Paul Barrett, of the Sanders Lab, on winning the Leon W. Cunningham Award in Biochemistry for 2012.
News posted by karen.d.davis@vanderbilt.edu: Daniel Putnam presents MBTP/CSB Seminar on 7/16/2013Daniel Putnam, of the Meiler Lab, presents the MBTP/CSB Seminar: "Small Angle X-Ray Scattering (SAXS) restraints to assist Protein Structure Prediction" on Tuesday, July 16, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Tina Iverson presents MBTP/CSB Seminar on 7/9/2013Tina Iverson, Ph.D., presents the MBTP/CSB Seminar: "Mechanisms of molecular recognition: methods and case studies" on Tuesday, July 9, 2013 at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Registration open for 2013 Career Symposium: "Influencing Human Health with your Ph.D."Registration for the 2013 Career Symposium: "Influencing Human Health with your Ph.D." is now open. The symposium, co-sponsored by the BRET Office of Career Development and the Vanderbilt Medical Alumni Association, will be held on July 31 in Light Hall. Admission is free, but advanced registration is required.
News posted by karen.d.davis@vanderbilt.edu: Walter Chazin and Sophia Gayek present MBTP/CSB RCR Special Session on 6/25/2013Walter Chazin, Ph.D., and Sophia Gayek, of the Ryoma Ohi Lab, present the MBTP/CSB RCR Special Session: "Combating explicit and implicit bias against women in science" on Tuesday, June 25, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Elizabeth Dong Nguyen - Dissertation Defense 6/17/2013Elizabeth Dong Nguyen, of the Meiler Lab, presents "Structural Studies of the Interaction between mGlu5 and Allosteric Modulators" on Monday, June 17, at 3:30pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Jonathan Schlebach presents MBTP/CSB Seminar on 6/18/2013Jonathan Schlebach, of the Sanders Lab, presents the MBTP/CSB Seminar: "Reversible Folding of Human Peripheral Myelin Protein 22: A Tetraspan Membrane Protein" on Tuesday, June 18, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Walter Chazin presents MBTP/CSB Seminar on 6/4/2013Walter Chazin, Ph.D., presents the MBTP/CSB Seminar: "The dynamic structure of proteins in action: Initiation of DNA synthesis at the replication fork" on Tuesday, June 4, at 12:30pm-1:20pm in 1220 MRBIII. News posted by karen.d.davis@vanderbilt.edu: Qiuyan Chen presents MBTP/CSB Seminar on 5/28/2013Qiuyan Chen, of the Iverson & Gurevich Labs, presents the MBTP/CSB Seminar: "Arrestin shape-shifting: NMR study of free and receptor-bound arrestin" on Tuesday, May 28, at 12:30pm-1:30pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Meiler Lab Releases BCL 3.0The Meiler Lab announces the release of BCL 3.0 for all Vanderbilt scientists. The latest version of the BioChemical Library (BCL) Software Suite is comprised of a collection of C++ algorithms designed to simulate biological molecules, proteins and peptides in particular, as well as small chemicals such as therapeutics.
News posted by karen.d.davis@vanderbilt.edu: Stephanie Hirst DeLuca to Present at 2013 Membrane Protein Folding ConferenceStephanie Hirst DeLuca, of the Meiler Lab, presents "RosettaEPR: Combining Computational Rigid Body Sampling with Sparse EPR Data to Improve Membrane Protein Structure Determination" at the 2013 Membrane Protein Folding Conference to be held May 19 - 22 in Seoul, South Korea.
News posted by karen.d.davis@vanderbilt.edu: Elizabeth Nguyen Named Co-winner of the Vanderbilt 3-Minute Thesis CompetitionCongratulations to Elizabeth Nguyen, of the Meiler Lab, for co-winning the Vanderbilt 3-Minute Thesis Competition for her presentation "Progress Towards Unlocking the Treatment for Cognitive Impairment."
News posted by karen.d.davis@vanderbilt.edu: Martin Egli presents MBTP/CSB Seminar on 5/7/2013Martin Egli, Ph.D., presents the MBTP/CSB Seminar: "The KaiABC post-translational circadian oscillator: insights from and challenges for structural biology" on Tuesday, May 7, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Biophysics Symposium to be held in the Bluegrass StateThe Biophysical Society (BPS) is hosting the Bluegrass Molecular Biophysics Symposium on Monday, May 20, at the University of Kentucky. The event begins at 8:30am with registration and poster set up.
News posted by karen.d.davis@vanderbilt.edu: Tyler Gilcrest - Honors Thesis Defense on 4/23/2013Tyler Gilcrest presents "Computational Docking of Chromone-Based Inhibitors into Signal Transducer and Activator of Transcription (STAT) Proteins" on Tuesday, April 23, at 1:00pm - 3:00pm in MRBIII, Room 5131. News posted by karen.d.davis@vanderbilt.edu: Register Now for the HTS Workshop on April 26Register now for the Virtual High-Throughput Screening (HTS) Workshop on April 26. The workshop begins takes place in Stevenson Center, Room 5119, from 9am to 5pm.
News posted by karen.d.davis@vanderbilt.edu: Nicholas Reiter Presents MBTP/CSB Seminar on 4/23/2013Nicholas Reiter, Ph.D., presents the RCR Special Session: "Conflicting interests and the fate of the whistleblower" on Tuesday, April 23, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Matthew Thompson Presents MBTP/CSB Seminar on 4/16/2013Matthew Thompson, Ph.D., of the Armstrong Lab, presents the MBTP/CSB Seminar: "Structural and Chemical Biology of Fosfomycin Resistance Proteins" on Tuesday, April 16, at 12:30pm-1:30pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Virtual High-Throughput Screening Workshop on April 26The Meiler Lab is hosting a Virtual High-Throughput Screening (HTS) Workshop on April 26 at 9am - 5pm in Stevenson Center, Room 5119. The Meiler Lab has produced a user-friendly platform that allows researchers without specific training in quantitative structure-activity relationship (QSAR) methodology to design and execute virtual screens. The HTS Workshop will cover the entire workflow of the QSAR methodology providing an introduction and training to interested researchers.
News posted by karen.d.davis@vanderbilt.edu: Martin Egli Selected to Give the 2013 Alexander Rich LectureCongratulations to Biochemistry Professor Martin Egli, Ph.D., on being selected to give the 2013 Alexander Rich Lecture at MIT. Dr. Egli will present "Structure and Mechanism of the KaiABC Post-Translational Circadian Oscillator" on April 9.
News posted by walter.chazin@vanderbilt.edu: Chrystal Starbird and Amanda Duram awarded NSF fellowshipsCongratulations to Chrystal Starbird of the Iverson lab and Amanda Duran of the Meiler lab, who have been awarded 2013 NSF graduate fellowships! News posted by karen.d.davis@vanderbilt.edu: Andrew Link Presents MBTP/CSB Seminar on 4/2/2013Andrew Link, Ph.D., presents: "Translation Complexes: Catalytic Engines or Regulatory Elements?" on Tuesday, April 2, at 12:30pm-1:20pm in MRBIII, Room 1220.
News posted by karen.d.davis@vanderbilt.edu: Georges Mer Presents Biochemistry 337 Seminar on 4/1/2013Georges Mer, Ph. D., presents the Biochemistry 337 Seminar: "Structural insights into the mode of action of histone chaperones" on Monday, April 1, at 4:00pm-5:00pm in Light Hall, Room 512.
News posted by karen.d.davis@vanderbilt.edu: Walter Chazin Presents Molecular Toxicology Seminar on 3/25/2013CSB Director Walter J. Chazin presents the Center in Molecular Toxicology Seminar: "Structural analysis of XPC, XPA and RPA and their roles in nucleotide excision repair" on Monday, March 25, at 12:00pm-1:00pm in Light Hall, Room 512. News posted by karen.d.davis@vanderbilt.edu: Nikolaus Grigorieff presents MBTP/CSB Seminar on 3/26/2013Invited speaker Nikolaus Grigorieff, Ph.D., from Brandeis University, presents the MBTP/CSB Seminar: "Cryo-EM with movies: Higher resolution with optimized image contrast" on Tuesday, March 26, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Pedro Teixeira - Masters Thesis Defense 3/14/2013Pedro Teixeira, of the Meiler Lab, presents "Using Evolutionarily-Based Correlation Measures to Improve Protein Structure Prediction in BCL::Fold" on Thursday, March 14, in Preston Research Building, Room 206 at 1:00 pm. News posted by karen.d.davis@vanderbilt.edu: Samuel DeLuca Presents MBTP/CSB Seminar on 3/19/2013Samuel DeLuca, of the Meiler Lab, presents the MBTP/CSB Seminar: "Development of a Virtual High Throughput Protein-Ligand Docking System Incorporating QSAR Derived Chemical Data" on Tuesday, March 19, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Program in Microbial Pathogenesis Mini-Symposium on 4/12/2013The Program in Microbial Pathogenesis presents the mini-symposium: "Imaging Infectious Diseases" on Friday, April 12, at noon – 5:00 pm in the Student Life Center Board of Trust Room. This mini-symposium highlights the work of various Vanderbilt University investigators who apply imaging technology to the study of infectious diseases.
News posted by karen.d.davis@vanderbilt.edu: New CSB Staff Member: Mariena Silvestry RamosPlease welcome Mariena Silvestry Ramos, Ph.D., as the newest Center for Structural Biology staff member. Silvestry Ramos joins the center as the Manager of the Cryo-EM Facility following her recruitment from the New York Structural Biology Center.
News posted by karen.d.davis@vanderbilt.edu: Charles Day - Dissertation Defense 3/6/2013Charles Day, of the Kenworthy Lab, presents "Role of Cytoskeleton in Cholera Toxin Diffusion and Endocytosis" on Wednesday, March 6, in Light Hall, Room 214 at 2:00 pm. News posted by karen.d.davis@vanderbilt.edu: Gerald Stubbs Presents MBTP/CSB Seminar on 3/5/2013Gerald Stubbs, Ph.D., presents the MBTP/CSB Seminar: "The Prion, or There and Back Again - A fifty year journey from peptides to proteins to viruses to peptides" on Tuesday, March 5, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: CSB Researchers Unveil Antibacterial Protein’s Molecular WorkingsWalter Chazin, Ph.D., and Postdoc fellow Steven Damo, Ph.D., working in collaboration with Eric P. Skaar, Ph.D., and Postdoc fellow Thomas Kehl-Fie, Ph.D., report new insights to the workings of calprotectin, specifically how it binds the metal manganese. Their findings, published in the Proceedings of the National Academy of Sciences, could lead to unique antibacterials that limit a microbe’s access to metals and help develop new therapies to fight increasing resistance of bacteria to antibiotics.
News posted by karen.d.davis@vanderbilt.edu: Teru Nakagawa Presents MBTP/CSB Seminar on 2/26/2013Terunaga Nakagawa, M.D., Ph.D., presents the RCR Special Session: "How reproducible is your experiment?" on Tuesday, February 26, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Chuck Sanders Wins Protein Society AwardCongratulations to CSB researcher Chuck Sanders, Ph.D., on winning the 2013 Hans Neurath Award from The Protein Society. He shares the honor with Jennifer Doudna, Ph.D., of the University of California, Berkley.
News posted by karen.d.davis@vanderbilt.edu: CSB Research Spotlight - Galina LepeshevaCSB researcher Galina Lepesheva, Ph.D., and colleagues have been featured in the VUMC Reporter for their recent findings on the Trypanosoma cruzi protozoan parasite which causes Chagas disease. The deadly tropical infection is transmitted by biting insects called “kissing bugs” and is spreading around the world.
News posted by karen.d.davis@vanderbilt.edu: CSB Researchers Discover Genes Involved in Heart Rhythm DisordersWalter Chazin, Ph.D., and colleagues have discovered two new genetic mutations in two unrelated infants that cause recurrent cardiac arrest. The findings, published in the journal Circulation, add to the causes of the life-threatening condition in early infancy and may lead to expanded treatments.
News posted by karen.d.davis@vanderbilt.edu: William Wan Presents MBTP/CSB Seminar on 2/19/2013William Wan, of the Stubbs Lab, presents the MBTP/CSB Seminar: "Insights into prion polymorphism from the fungal prion HET-s" on Tuesday, February 19, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: ASBMB Student/Postdoc Hill Day: Call for ApplicationsIf you would like to be a part of the debate over the importance of research funding, then complete an application for the next Student/Postdoc Hill Day on March 18-20, 2013. The American Society for Biochemistry and Molecular Biology brings together young researchers from across the country to meet with their Congressional leaders in Washington, D.C.
News posted by karen.d.davis@vanderbilt.edu: Gregor Neuert presents MBTP/CSB Seminar on 2/5/2013Gregor Neuert, Ph.D., presents the MBTP/CSB Seminar: "Quantifying dynamic signal transduction and gene regulation in individual cells with single molecule resolution" on Tuesday, February 5, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: John Christodoulou presents CSB Special Seminar on 2/12/2013John Christodoulou, Ph.D., invited speaker from University College London, presents the CSB Special Seminar - "Protein Folding on the Ribosome" on Tuesday, February 12, at 12:30pm-1:30pm in MRBIII, Room 1220.
News posted by karen.d.davis@vanderbilt.edu: CSB Research SpotlightCSB researchers Walter Chazin, Charles Sanders and Tina Iverson have been featured in the VUMC Reporter for their recent findings on the DNA processing "hub" and light receptor's interactions.
News posted by karen.d.davis@vanderbilt.edu: Paul Barrett presents MBTP/CSB Seminar on 1/22/20132013 Karpay Award Winner Paul Barrett presents "Where is my doughnut? A link between cholesterol and Alzheimer's Disease" on Tuesday, Jan. 22, at 12:30 pm - 1:30 pm in MRB III, Room 1220. The award presentation and reception will follow.
News posted by karen.d.davis@vanderbilt.edu: Sanders & Iverson/Gurevich Labs Collaborate on Arrestin PaperThe Sanders Lab and the Iverson/Gurevich Lab have jointly published the paper, "Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin," in the Proceedings of the National Academy of Science, USA.
News posted by karen.d.davis@vanderbilt.edu: Brian Weiner presents Chemistry Seminar on 1/14/2013Brian Weiner presents the Chemistry Seminar - "BCL::MP-Fold: Folding Membrane Proteins through Assembly of Trans-Membrane Helices" on Monday, January 14, at 4:00pm-5:15pm in 5211 Stevenson Center. News posted by karen.d.davis@vanderbilt.edu: Paul Barrett receives Karpay AwardCongratulations to Paul Barrett for being named the 2013 recipient of The Anne Karpay Award in Structural Biology. “It is a great honor to be selected for the Karpay Award,” Barrett said.
News posted by karen.d.davis@vanderbilt.edu: Daniel Putnam - Masters Thesis Defense on 1/14/2013Daniel Putnam, of the Meiler Lab, defends his Masters Thesis: "BCL::SAXS - Small Angle X-Ray Scattering Profiles to Assist Protein Structure Prediction" on Monday, January 14, at 1:00 pm in PRB, Room 206. News posted by karen.d.davis@vanderbilt.edu: CSB co-sponsors The Flexner Discovery Lecture Series on 1/10/2013Brenda A. Schulman, Ph.D., presents The Flexner Discovery Lecture Series: "Twists and Turns in Ubiquitin Conjugation Cascade" on Thursday, January 10, at 4:00 pm in Light Hall, Room 208. This lecture is co-sponsored by Department of Biochemistry and Center for Structural Biology. News posted by karen.d.davis@vanderbilt.edu: Stephen Fesik presents MBTP/CSB Seminar on 1/8/2013Stephen Fesik, Ph.D., presents the MBTP/CSB Seminar: "Cancer drug discovery using fragment-based methods" on Tuesday, January 8, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: CSB Makes a Leipzig ConnectionVanderbilt University and the University of Leipzig have established a research connection thanks to Jens Meiler, associate professor of chemistry and primary investigator in the Center for Structural Biology. It began in 2007 when Meiler was invited to give a guest lecture at his alma mater while visiting family in Germany. His talk stirred up interest and opened a path for faculty members and graduate students from each university to spend time visiting, collaborating and studying at the other campus. Since there is a common research bond, the administrations of the two universities have signed a five-year memorandum of understanding that allows and encourages academic exchanges, facilitates joint research programs, student programs and a cultural exchange program. Meiler and his colleagues have also received a grant from the National Science Foundation Office of International Science to develop this collaboration between the institutions. The Leipzig connection demonstrates how grassroots efforts of individual Vanderbilt researchers have led to formal relationships extending across many fields. Read the full article on the Research News at Vanderbilt website. News posted by karen.d.davis@vanderbilt.edu: Jens Meiler Presents MBTP/CSB Seminar on 12/18/2012Jens Meiler, Ph.D., presents an RCR Special Session: "Peer review of papers and proposals - how to prepare a constructive, fair, unbiased, effective review" on Tuesday, December 18, at 12:30 pm - 1:20 pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Albert Beth and Hassane Mchaourab elected AAAS fellowsCenter for Structural Biology core faculty members Albert Beth, Ph.D., and Hassane Mchaourab, Ph.D., have been elected fellows of the American Association for the Advancement of Science (AAAS). Dr. Beth, professor of Molecular Physiology and Biophysics, is honored for the development of high resolution spin label probes and for their utilization in determining the dynamics and structure of membrane proteins. Dr. Mchaourab, professor of Molecular Physiology and Biophysics, is acknowledged for pioneering contributions to the development of biological electron paramagnetic resonance (EPR) spectroscopy and to membrane protein structural biology. Dr. Beth and Dr. Mchaourab are among seventeen Vanderbilt University faculty members and 703 scientists nationwide to be elected fellows this year. They will be recognized on Feb. 16 at the 2013 AAAS annual meeting in Boston. To see a complete list of the Vanderbilt University faculty members selected and their achievements, read the full article in the Reporter. The Reporter is a weekly publication of Vanderbilt University Medical Center. News posted by karen.d.davis@vanderbilt.edu: CSB Investigators featured in Journal of Biological ChemistryF. Peter Guengerich, Ph.D., Martin Egli, Ph.D., and colleagues were featured on the cover of the Oct. 12 Journal of Biological Chemistry. Their publication documented how specific adducts, resulting from exposure to known carcinogens, may cause DNA errors that spur cancer formation. Read more about the research and publication in the Aliquots section of the Reporter. News posted by karen.d.davis@vanderbilt.edu: Terunaga Nakagawa Presents MBTP/CSB Seminar on 12/04/2012Terunaga Nakagawa, Ph.D., presents the MBTP/CSB Seminar - "Exploring the diversity and mechanism of AMPA receptor modulation by auxiliary factors" on Tuesday, December 4, at 12:30pm-1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Jessica Mazerik Presents MBTP/CSB Seminar on 11/13/2012Jessica Mazerik, of the Tyska Lab, presents the MBTP/CSB Seminar - "Using single molecule approaches to probe Myosin-1a membrane binding dynamics in cells" on Tuesday, November 13, at 12:20pm - 1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Rosetta Workshop 2012The Meiler Lab will host the 2012 Rosetta Workshop at Vanderbilt University November 14-16, 2012. The 3-day workshop will cover introductory exercises in the Rosetta protein modeling suite. Please visit the website for detailed information about the workshop. The registration fee for academic/non-profit participants is $200 and $1000 for industry participants. The registration fee includes select meals, snacks and registration materials. Limited spots are available, so register soon. Those interested in attending should complete a registration form and return it to c.fortenberry@vanderbilt.edu. News posted by karen.d.davis@vanderbilt.edu: Nicholas Reiter Presents MBTP/CSB Seminar on 11/06/2012Nicholas Reiter, Ph.D., presents the MBTP/CSB Seminar - "Structural mechanisms of the ribonuclease P enzyme: Insights into the RNA world past and present" on Tuesday, November 6, at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by karen.d.davis@vanderbilt.edu: Richard Armstrong, Ph.D., Presents MBTP/CSB Seminar on 10/23/2012Richard Armstrong, Ph.D., presents MBTP/CSB Seminar: "Ethical Obligations in the Publication of Science" on Tuesday, October 23, at 12:15pm - 1:15pm in Light Hall, Room 208. News posted by karen.d.davis@vanderbilt.edu: Daniel Huster, Ph.D., Presents VICB SeminarDaniel Huster, Ph.D., visiting professor from the University of Leipzig, presents the VICB Seminar - "Solid-state NMR Methods to Study Challenging Biological Systems: Membrane Proteins, Amyloids, Tissue" on Tuesday, October 9, at 12:15pm in MRBIII, Room 1220. The seminar is co-sponsored by CSB. For more information, contact: anne.b.lara@vanderbilt.edu. News posted by karen.d.davis@vanderbilt.edu: Kathryn McCulloch, Ph.D. Presents MBTP/CSB Seminar on 10/16/2012Kathryn McCulloch, Ph.D., of the Iverson Lab, presents the MBTP/CSB Seminar - "Investigation into the Basis of Orthoester Bond Formation in Everninomicin" on Tuesday, October 16, at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by walter.chazin@vanderbilt.edu: Lacy promoted to Associate Professor with tenureCongratulations to Borden Lacy on her promotion, which was just approved this week by the Board of Trust! News posted by sheila.webb@vanderbilt.edu: Mchaourab to lead Chemical and Physical Biology programCongratulations to Hassane Mchaourab, Ph.D., professor of Molecular Physiology & Biophysics, Physics and Chemistry, who has been named the new director of the Ph.D.-granting Chemical and Physical Biology (CPB) program at Vanderbilt University. Read the full article in the VUMC Reporter. News posted by Jessica.Greer@Vanderbilt.edu: Desiree Benefield Presents MBTP/CSB Seminar on 9/18/2012Desiree Benefield, of the Lacy Lab, presents the MBTP/CSB Seminar - "Portrait of a killer: A microscopy study of the botulinum neurotoxin complex" on Tuesday, September 18 at 12:20pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Gordon Lemmon – Dissertation Defense, 09/18/2012Gordon Lemmon of the Meiler Lab Presents, "Development of Methods for Docking and Designing Small Molecules within the Rosetta Code Framework" on Tuesday, September 18 in MRBIII, Room 3131 at 10:00 am. News posted by Jessica.Greer@Vanderbilt.edu: Melanie Ohi Presents MBTP/CSB Seminar on 9/11/2012Melanie Ohi, Ph.D. presents "RCR Special Session" on Tuesday, September 11 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Charles Sanders Presents MBTP/CSB Seminar on 9/4/2012Charles Sanders, Ph.D. presents the MBTP/CSB Seminar - "What Should PhD Students and Postdoctoral Fellows Expect From Themselves" on Tuesday, September 4 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Anne Kenworthy Presents MBTP/CSB Seminar on 8/7/2012Anne Kenworthy, Ph.D. presents "Role of glycolipid binding toxins in the assembly and function of membrane domains" on Tuesday, August 7 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Hitoshi Kurumizaka Presents MBTP/CSB Seminar on 8/14/2012Hitoshi Kurumizaka, Ph.D., Professor, Faculty of Science and Engineering, Waseda University, Tokyo, Japan will present - "Structures of human nucleosomes containing histone variants, and their functional versatility" on Tuesday, August 14 at 12:30pm - 1:20pm in MRBIII, Room 1220. Dr. Kurumizaka host is Melanie Ohi, Assistant Professor in Cell and Developmental Biology. News posted by Jessica.Greer@Vanderbilt.edu: Richard Armstrong named a Fellow of the American Chemical SocietyCongratulations to Richard Armstrong, who has been named a Fellow of the American Chemical Society. Richard is the third Vanderbilt faculty member to be named an ACS Fellow, joining Fred Guengerich (2009) and Larry Marnett (2010). This is truly a significant honor that recognizes sustained contribution to the discipline of chemistry, an award that is richly deserved. Bravo Richard. For more information, read the Reporter article. News posted by Jessica.Greer@Vanderbilt.edu: Steve Damo Presents MBTP/CSB Seminar on 7/17/2012Steve Damo, Ph.D. presents the MBTP/CSB Seminar - "Molecular basis for the broad spectrum antimicrobial activity of calprotectin" on Tuesday, July 17 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Brandt Eichman & James Goldenring Presents MBTP/CSB Seminar on 6/26/2012Brandt Eichman, Ph.D. and James Goldenring, M.D., Ph.D. presents the MBTP/CSB Seminar - “Guilty Until Proven Innocent: The Realities of Research Ethics" on Tuesday, June 26 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Yuanli Song Presents MBTP/CSB Seminar on 6/19/2012Yuanli Song, Ph.D., presents the MBTP/CSB Seminar - "Molecular Insights into the Roles of C99 and Cholesterol in Alzheimer’s Disease", on Tuesday, June 19 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Matthew Lang Presents MBTP/CSB Seminar on 6/5/2012Matthew Lang, Ph.D., presents the MBTP/CSB Seminar - "Measuring unfolding and translocation by an ATP-fueled proteolytic machine" on Tuesday, June 5 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Sanders Lab Clarifies the Relationship of Cholesterol to Alzheimer's DiseaseWhile more than 1500 papers have been published on cholesterol and Alzheimer's disease, why cholesterol promotes the disease remains murky. In an article published in the June 1 issue of Science Chuck Sanders and his co-workers in the Center for Structural Biology have shed light on this issue by showing that cholesterol forms a direct complex with the amyloid precursor protein (APP), from which the toxic agent of Alzheimer's disease, amyloid-beta, is derived. Drugs that prevent binding of cholesterol to APP may help to avoid the production of amyloid-beta, which might help to prevent or even treat Alzheimer's. Read the full article at sciencemag.org. Also read the article in the Vanderbilt Reporter News posted by Jessica.Greer@Vanderbilt.edu: Michael Waterman Receives an Academic Enterprise Faculty AwardMichael Waterman was presented with John H. Exton Award for Research Leading to Innovative Biological Concepts at the spring faculty meeting on May 17, 2012. He was recognized for his outstanding contributions to research. Congratulations Dr. Waterman. News posted by Jessica.Greer@Vanderbilt.edu: Symposium on Frontiers in Biomolecular NMR on 5/5/2012The Vanderbilt University Center for Structural Biology will host this symposium as a re-dedication of the Biomolecular NMR Facility, marking a series of major upgrades, including installation of a new 900 MHz NMR spectrometer. This will be held on Saturday, May 5, 2012 from 9:00am - 5:00 pm. Please visit the link below for details. http://structbio.vanderbilt.edu/nmr/Symposium_2012/program_symposium.php News posted by Jessica.Greer@Vanderbilt.edu: NMR Workshop sponsored by Bruker BioSpin on 5/4/2012NMR Workshop to be held on May 4, 2012 from 9:30am - 4:00 pm. Please visit the link below for more information. http://structbio.vanderbilt.edu/nmr/Symposium_2012/program_workshop.php News posted by Jessica.Greer@Vanderbilt.edu: Borden Lacy Presents MBTP/CSB Seminar on 5/1/2012Borden Lacy, Ph.D., presents the MBTP/CSB Seminar - "Structure and Function of Clostridium difficile Toxins A and B", on Tuesday, May 1 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by jessica.greer@vanderbilt.edu: Nathan Alexander – Dissertation Defense, 04/24/2012Nathan Alexander of the Meiler Lab Presents, “Protein Structure Elucidation from Computation Techniques and Sparse EPR Data” on Tuesday, April 24 in MRBIII, Room 1220 at 2:00 pm. News posted by Jessica.Greer@Vanderbilt.edu: Gage Matthews Presents Chemical & Physical Biology Program Special Seminar on 4/18/2012Gage Matthews of the Beth Lab, presents "Structural Determination of Local Movements of the FG-Loop and Alpha-Helix of Sodium-Calcium Exchanger NCX1.1 Upon Binding of Calcium Ions" on Wednesday, April 18 at 2:00pm - 3:00pm in PRB, Room 206. News posted by Jessica.Greer@Vanderbilt.edu: Stephen Fesik to receive 2012 AACR Award for Outstanding Achievement in Chemistry in Cancer ResearchStephen Fesik, Ph.D., Professor Biochemistry, Pharmacology and Chemistry will receive the 2012 American Association for Cancer Research (AACR) Award. He is receiving the special recognition for his use of nuclear magnetic resonance (NMR) to discover novel, potent small molecules capable for use as cancer therapeutics. Fesik will receive the award and will deliver a special lecture at the AACR Annual Meeting in Chicago, IL. Congratulations to Professor Fesik! News posted by Jessica.Greer@Vanderbilt.edu: Julia Koehler Leman - Dissertation Defense, 4/11/2012Julia Koehler Leman of the Meiler & Sanders Labs presents, "Method development for membrane protein structure determination using NMR spectroscopy and computational techniques" on Wednesday, April 11 in PRB, Room 206 at 2:00pm. News posted by Jessica.Greer@Vanderbilt.edu: Kristin N. Parent Presents MPB/CSB Faculty Candidate Seminar on 4/2/2012Kristin N. Parent, Ph.D., Postdoctoral Fellow, from the University of California, San Diego presents "Cryo-EM studies of viruses and bacteriophage: Past, present and future directions" on Monday April 2 at 10:00am - 11:00am in PRB, Room 206. Dr. Parent host is Hassane Mchaourab, Professor in Molecular Physiology and Biophysics. News posted by Jessica.Greer@Vanderbilt.edu: Michael Waterman Awarded the 2012 Schroepfer MedalMichael Waterman, Natalie Overall Warren Distinguished Professor of Biochemistry, has been awarded the 2012 Schroepfer Medal by the American Oil Chemists’ Society (AOCS) for his contributions to the steroid/sterol field. Waterman will receive a medal and honorarium, and will give an award lecture at the AOCS Annual Meeting in Long Beach, California. Congratulations to Professor Waterman! News posted by Jessica.Greer@Vanderbilt.edu: Paul Bock Presents MBTP/CSB Seminar on 4/3/2012Paul Bock, Ph.D., presents the MBTP/CSB Seminar - "The staphylocoagulase family of zymogen activators and adhesion proteins (ZAAPs)" on Tuesday April 3 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Sam DeLuca - MBTP/CSB Seminar, 3/20/2012Sam DeLuca of the Meiler Lab presents "Design of native-like proteins through an exposure-dependent environment potential" on Tuesday, March 20, 2012 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Michael Waterman Presents Molecular Toxicology Seminar on 03/19/2012Michael Waterman, Ph.D, presents the Molecular Toxicology Seminar - "Unusual Properties of the Cytochrome P450 Superfamily" on Monday, March 19 at 12:00pm - 1:00pm in Light Hall, Room 512. News posted by sheila.webb@vanderbilt.edu: Linda Columbus – Chemistry Colloquium Series, 03/19/2012Linda Columbus, Ph.D., Assistant Professor, University of Virginia presents, “Membrane protein structural biology: from micelles to bacterial invasion” on Monday, March 19 at 4:15pm in Stevenson Center 5211. Dr. Columbus host is Jens Meiler, Associate Professor in Chemistry. News posted by Jessica.Greer@Vanderbilt.edu: International Hybrid Structural Biology Conference 2012The conference aims to illustrate the power of combining state of the art methods to tackle important and challenging biological problems and to identify limitations and gaps in currently practiced hybrid methods. The central premise is that gaining a comprehensive understanding of the highly sophisticated complexes, machines, and organelles of the cell requires the coordinated application of complementary biophysical approaches hybrid methods). This will be held at Granlibakken Conference Center, Lake Tahoe from 8:00am - 12:00 pm on Wednesday March 14, 2012. News posted by Jessica.Greer@Vanderbilt.edu: Michael Waterman - “Unusual Properties of the Cytochrome P450 Superfamily”Michael Waterman, Ph.D, presents “Unusual Properties of the Cytochrome P450 Superfamily” on Tuesday, March 6 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Mirko Hennig - Chemistry Colloquium SeriesMirko Hennig presents "RNA-protein interactions involved in microRNA biogenesis" on Monday, February 20 at 4:15 - 5:30pm in the Stevenson Center Room 5211. News posted by sheila.webb@vanderbilt.edu: Hassane Mchaourab, Ph.D. MBTP/CSB Seminar, 02/07/2012Hassane Mchaourab, Ph.D. presents, "Conformational Dynamics of Membrane Proteins. The View from Spin Labeling and ERP Spectroscopy" on Tuesday, February 7 at 12:30 1:20pm in MRBIII, Room 1220 News posted by sheila.webb@vanderbilt.edu: Ezelle McDonald – Dissertation Defense, 02/14/2012Ezelle McDonald of the Mchaourab Lab Presents, “The Role of the N-terminal Domain in the Dynamics of Hsp27 Equilibrium Dissociation” on Tuesday, February 14 in Light Hall, Room 208 at 10:00a. Reception will be held in MRBIV, 7th floor Atrium at 2:00p. News posted by sheila.webb@vanderbilt.edu: Mary Carroll wins Vanderbilt’s first Damon Runyon FellowshipMary Carroll, Ph.D., a postdoctoral research fellow in Biochemistry, (Fesik lab) was recently named one of 18 Damon Runyon Fellows by the Damon Runyon Cancer Research Foundation. The three-year, $156,000 award provides independent funding for outstanding postdoctoral scientists to pursue innovative projects. Carroll is the first postdoctoral fellow from Vanderbilt to receive this award. News posted by just_jessica01@hotmail.com: Elitza Tocheva - Faculty Candidate Seminar - 1/12/2012Elitza Tocheva, of the California Institute of Technology, Department of Biology presents "Electron Cryo-Tomography of Bacterial Endospore Formation", on Thursday January 12th at 10:00 am in 512 Light Hall. News posted by Jessica.Greer@Vanderbilt.edu: William Heller - MBTP/CSB Seminar, 1/10/2012William Heller of the Biology and Soft Matter Division of Oak Ridge National Laboratory presents "Neutron Scattering for Investigating the Structures of Biological Systems" on Tuesday, January 10, 2012 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Christina K. Williams - Dissertation Defense, 12/21/2011Christina K. Williams of the Chazin Lab Presents, "Biochemical and Structural Analysis of SV40 Large T Antigen: Insights Into Chaperone Mediated Inactivation Of Retinoblastoma Tumor Suppressor Protein" on Wednesday, December 21 in MRBIII, Room 1220 at 9:00am. News posted by Jessica.Greer@Vanderbilt.Edu: Meiler Student, Sam DeLuca, wins fellowshipSam DeLuca, graduate student in the Meiler laboratory, wins an "Informatics" graduate student fellowship from the Phrma foundation. Sam's research focuses on computational modeling of protein-small molecule interactions for drug discovery. News posted by Jessica.Greer@Vanderbilt.edu: Brittany Allison - NSF Graduate Research FellowshipBrittany Allison, a chemistry student in the Meiler laboratory, received a prestigious National Science Foundation (NSF) Graduate Research Fellowship. Brittany works on computationally engineering proteins that bind small molecules. Her research has implications for understanding the fundamentals of protein-ligand interaction, engineering enzymes, and protein therapeutics. Brittany will start her fellowship after completing her training on the Chemical Biology Training Program, an NIH-funded initiative of Vanderbilt's Institute for Chemical Biology and the Chemistry Department. News posted by Jessica.Greer@Vanderbilt.edu: 2012 Karpay Award WinnerCongratulations to the 2012 Karpay Award winner Chris A. Brosey. News posted by Jessica.Greer@Vanderbilt.edu: Home Lab SAD phasing with HKL3000: From data collection to refined models in less than an hour.Jim Pflugrath, Ph.D., presents Home Lab SAD phasing with HKL3000: From data collection to refined models in less than an hour. This will be held in MRB III, Room 5131 from 10:00am - 11:00am. All are invited to attend and pre-registration can be done via http://www.rigaku.com/protein/webinars.html or you can just attend the webinar without pre-registering. News posted by Jessica.Greer@Vanderbilt.edu: "Structural mechanisms for excision repair of DNA alkylation damage"Brandt Eichman, Ph.D., presents "Structural mechanisms for excision repair of DNA alkylation damage" on Monday November 14, 2011 in the Stevenson Center, Room 5211 from 4:00pm until 5:30pm. News posted by Jessica.Greer@Vanderbilt.Edu: Alan Bentley - “The tangled web of inventorship and patenting of academic technologies”Alan Bentley, Assistant Vice Chancellor, Center for Technology Transfer and Commercialization presents “The tangled web of inventorship and patenting of academic technologies” on Tuesday, November 15 at 12:30pm - 1:20pm in MRBIII, Room 1220. News posted by Jessica.Greer@Vanderbilt.edu: Graduate Student Spotlight - Daniel PutnamDaniel Putnam, graduate student in the Meiler laboratory, received 2nd place for his oral presentation at the American Medical Informatics Association 2011 annual symposium for his presentation "Exploring Schizophrenia Drug-Gene Interactions Through Molecular Network and Pathway Modeling". He completed the project during his research rotation with the Zhongming Zhao laboratory. News posted by Jessica.Greer@Vanderbilt.edu: Laurel Hoffman - Dissertation Defense, 10/25/2011Laurel Hoffman of the Machaourab Lab presents, “Investigation of CaMKII Activation: A Model of Self-Regulation” on Tuesday, October 25 at 10:00am – 11:00am in Light Hall, Room 208. News posted by Jessica.Greer@Vanderbilt.edu: New protein architectures involved in genome maintenanceBrandt Eichman, Ph.D. is holding a seminar on Monday, October 17, 2011 at 512 Light Hall from 12:00 pm - 1:00 pm on "New protein architectures involved in genome maintenance". News posted by barry.a.noland@vanderbilt.edu: Ulrike Krug - MBTP/CSB Seminar, 10/18/2011Ulrike Krug, visiting student in the Meiler Lab, presents "Crystallographic and Spectroscopic Studies (EPR,NMR) on the Domain Motion of Nucleotidases from Toxoplasma Gondii and E. Coli" on Tuesday, October 18 from 12:30-1:20 in MRB III, Room 1220. News posted by barry.a.noland@vanderbilt.edu: Presentation by John P. Wikswo, Ph.D.John P. Wikswo, Ph.D., Gordon A. Cain University Professor, Department of Physics & Astronomy, will be presenting on Tuesday, October 4, from 12:30-1:20pm in MRB III, Room 1220. News posted by barry.a.noland@vanderbilt.edu: Nils Woetzel - Dissertation Defense, 09/28/2011Nils Woetzel of the Meiler Lab presents, "A Novel Approach to De Novo Protein Structure Prediction using Knowledge-based Energy Functions and Experimental Restraints" on Wednesday, September 28 from 2:00-3:00pm in the Stevenson Center, Room 5502. News posted by sheila.webb@vanderbilt.edu: Martin Egli, Ph.D. – Center in Molecular Toxicology Seminar, 09/19/2011Martin Egli, Ph.D. presents, “The Steric Hypothesis for DNA Replication – Revisited in Light of New Structural Data” on Monday, September 19 at 12:00pm in Light Hall, Room 512. News posted by sheila.webb@vanderbilt.edu: Paul Barrett – MBTP/CSB Seminar, 09/20/2011Paul Barrett of the Sanders Lab presents, “Untangling Alzheimer’s Disease: What can structural biology tell us about disease regulation?” on Tuesday, September 20 at 12:30 – 1:20pm in MRB III, Room 1220. News posted by sheila.webb@yahoo.com: Thomas Ellenberger, DVM, Ph.D. – Biochemistry Fall Seminar, 09/19/2011Thomas Ellenberger, DVM, Ph.D., Professor and Head of Biochemistry and Molecular Biology, Washington University School of Medicine presents, “Cellular Responses to DNA Damage†on Monday, September 19 at 4:00pm in Light Hall, Room 512. Dr. Ellenberger host is Fred Guengerich, Professor and Interim Chair of Biochemistry. News posted by sheila.webb@vanderbilt.edu: Brandt Eichman, Ph.D. – VICB Seminar, 09/07/2011Brandt Eichman, Ph.D., presents, “New Twists and Grooves in DNA Base Excision Repair” on Wednesday, September 7 at 12:15p in MRB III, Room 1220. News posted by sheila.webb@vanderbilt.edu: Brandt Eichman honored with faculty awardThe Chancellor’s Awards for Research were presented at the fall faculty assembly on August 25, 2011. Brandt Eichman was honored this year. Brandt was one of six recipients of the Chancellor’s Award for Research that recognizes excellence in research, scholarship, or creative expression. This marks the second consecutive year that CSB faculty have been honored by this award, and the fifth recognition since 2003 (Chuck Sanders - 2010, Walter Chazin - 2006, Hassane Mchaourab - 2006, Martin Egli - 2005). Congratulations to Professor Eichman! News posted by sheila.webb@vanderbilt.edu: Chris A. Brosey – Dissertation Defense, 08/31/2011Chris A. Brosey of the Chazin Lab presents, “Investigating the Architectural Basis of RPA Quaternary Remodeling upon Binding ssDNA” on Wednesday, August 31 at 1:00 – 2:00pm in Light Hall, Room 214. News posted by sheila.webb@vanderbilt.edu: Mert Karakas - Dissertation Defense, 09/01/2011Mert Karakas of the Meiler Lab presents, “BCL::Fold-De novo Protein Structure Prediction by Assembly of Secondary Structure Elements" on Thursday, September 1 at 1:00 – 2:00pm in Light Hall, Room 202. News posted by sheila.webb@vanderbilt.edu: Tina Iverson, Ph.D. – MBTP/CSB Seminar, 09/06/2011Tina Iverson, Ph.D., presents, “How to select, express, and purify a membrane protein for structural studies: tips and tricks from 7 case studies” on Tuesday, September 6 at 12:30 – 1:20pm in MRB III, Room 1220. News posted by sheila.webb@vanderbilt.edu: Rory Pruitt - Dissertation Defense, 09/6/2011Rory Pruitt of the Lacy Lab presents, “Structural Analysis of Clostridium Difficile Toxins A and B” on Tuesday, September 6 at 3:00 – 4:00pm in MRB III, Room 1220. News posted by sheila.webb@vanderbilt.edu: Collaboration with Meiler Group shows how G proteins get ‘turned on’ by receptorsThe structure of G proteins was solved nearly 20 years ago, but exactly how they are "turned on" by their G protein-coupled receptors (GPCRs) has remained a mystery until now. News posted by sheila.webb@vanderbilt.edu: Accepting application for 2011 Karpay Award in Structural BiologyThe Karpay Award was established in 2010 to recognize one graduate student each year who has both made outstanding contributions to structural biology (broadly defined) and exhibits a well-rounded and collegial character. The award is contingent upon presenting a seminar in the MBTG series during January and consists of a $1500 honorarium. The name of the recipient will be added to a plaque housed in the CSB. Applications will be accepted by email to tina.iverson@vanderbilt.edu until 5PM on September 1. Click here for Application Instructions News posted by sheila.webb@vanderbilt.edu: Congratulations -- Edward W. LoweThe National Science Foundation awards a fellowship of $240,000 to Edward W. Lowe, post-doctoral fellow in the Meiler lab, for support of the project, "PROPMAP: A Novel GPU-accelerated Structure-Property Relationship Mapping Algorithm Utilizing Volunteer Computing." News posted by sheila.webb@vanderbilt.edu: Michael P. Stone, Ph.D. – Center in Molecular Toxicology Seminar, 08/15/2011Michael P. Stone, Ph.D. presents, "Chemistry in the Major Groove of DNA" on Monday, August 15 at 12:00pm – 1:00pm in Light Hall, Room 512. News posted by sheila.webb@vanderbilt.edu: Scott Collier – MBTP/CSB Seminar, 08/16/2011Scott Collier of the Ohi Lab presents, "Structural and functional characterization of Cdc5, an essential splicing factor" on Tuesday, August 16 at 12:30 pm – 1:20 pm in MRBIII, Room 1220. News posted by Sonia.N.Leggs@vanderbilt.edu: Kelli Kazmier, a graduate student in the Mchaourab laboratory, received a National Research Award.Kelli Kazmier received a T31 individual predoctoral fellowship from the National Institute for Mental Health to fund her thesis research entitled "Conformational Changes Underlying Intracellular Gating of the Leucine Transporter". The award is for two years and began in August, 2011 with the fellowship providing funds toward tuition, fees, and stipend with some additional funding for travel and lab resources. Congratulations Kelli Kazmier! News posted by Sonia.N.Leggs@vanderbilt.edu: Darren Mushrush - Dissertation Defense, 08/04/2011Darren Mushrush of the Lacy Lab presents, "Mechanistic Details of the pH-Dependent Association of Botulinum Neurotoxin with Membranes", on Thursday, August 4th at 3:00 - 4:00pm, in Preston Research Building Room 206. News posted by Sonia.N.Leggs@vanderbilt.edu: Brandt Eichman Ph.D. - MBTP/CSB Seminar, 08/02/2011Brandt Eichman, Ph.D., presents, "Structural mechanisms for excision repair of DNA alkylation damage" on Tuesday, August 2, 2011 at 12:30 - 1:20 pm in the MRB III, Room 1220. News posted by sonia.n.leggs@vanderbilt.edu: Lauren Jackson - The Biological Sciences Seminar, 08/01/2011Lauren Jackson from the University of Cambridge, UK, presents “Structural basis for endocytic cargo recognition at the plasma membrane” on Monday, August 1st, 2011 at 4:10 pm - 5:00 pm in the MRB III, Room 1220. News posted by sheila.webb@yahoo.com: Steven Combs – MBTP/CSB Seminar, 07/19/2011Steven Combs of the Meiler lab presents, “Engineering Proteins with Rosetta” on Tuesday, July 19 at 12:30 pm – 1:20 pm in MRB III, Room 1220 News posted by jsmith@structbio.vanderbilt.edu: Chuck Sanders receives prestigious awardChuck Sanders is the recipient of 2012 Anatrace Membrane Protein Award from the Biophysical Society. This award recognizes his groundbreaking work on both discovering new methods for stabilizing membrane proteins and using NMR to understand the structure and dynamics of membrane proteins. The award will be presented to Dr. Sanders on Tuesday Feb. 28, 2012 during the Awards Symposium at the Annual Biophysical Society Meeting in San Diego, CA. News posted by sheila.webb@vanderbilt.edu: Melissa Ann Fischer (Steapleton) – Dissertation Defense, 7/8/2011Melissa Ann Fischer (Steapleton) of the Armstrong Lab presents, “The Characterization of Myeloid Translocation Gene 16 in Hematopoietic Progenitor and Stem Cell Functions”, on Friday, July 8 at 1:00 pm in PRB, Room 898-J. News posted by sheila.webb@vanderbilt.edu: Ileana Alers -- Masters Dissertation Defense, 6/28/2011Ileana Alers of the Chazin Lab presents, "NMR analysis of the RPA dimer core RPA32D/14", on Tuesday, June 28 at 12:30 pm – 1:20 pm in MRB III, Room 1220. News posted by sheila.webb@vanderbilt.edu: Matthew Tyska, MBTP/CSB Seminar - 7/5/11Matthew Tyska, Assistant Professor, Cell and Developmental Biology presents: “Studying molecular motors in live cells using single molecule TIRF microscopy” on Tuesday, July 5 at 12:30 pm – 1:20 pm in MRB III, Room 1220. News posted by sheila.webb@vanderbilt.edu: Mike Shell – MBTP/CSB Seminar, 06/21/2011Mike Shell of the Chazin lab presents, “DNA Damage Recognition in the Nucleotide Excision Repair Pathway” on Tuesday, June 21 at 12:30 pm – 1:20 pm in MRB III, Room 1220. News posted by sheila.webb@vanderbilt.edu: Megan Waddington Branch – Dissertation Defense, 06/22/2011Megan Waddington Branch of the Armstrong Lab presents, "Exploring New Structural and Functional Space in the Glutathione Transferase Superfamily from Escherichia coli K-12", on Wednesday, June 22 at 2:00 pm – 3:00 pm in Light Hall Room 512. News posted by jarrod.smith@vanderbilt.edu: Chuck Sanders and Michael Waterman honored with faculty awardsThe Vanderbilt University Medical Center Academic Enterprise Faculty Awards were presented at the spring faculty meeting on May 25, 2011. Two CSB faculty members were honored this year. Chuck Sanders was presented with the Sidney P. Colowick Award for Research that Serves as a Platform for Discovery in Diverse Areas. Michael Waterman received the F. Peter Guengerich Award for Mentoring Postdoctoral Fellows or Residents in the Research Setting. Congratulations to Profs. Sanders and Waterman!
News posted by sonia.n.leggs@vanderbilt.edu: SBGrid Hosts Webinar, "Advances in Structural Biology Computing"On Friday, June 24th, 2011, SBGrid will webcast a special one day symposium for members of the SBGrid community. Several key software developers will present their latest tools for solving structures by X-ray crystallography. Joel Harp will host the webcast in the CSB conference room (5131 MRBIII). Click the link below for a detailed agenda. News posted by jarrod.smith@vanderbilt.edu: Huge New Magnet to Enhance Cancer Drug Discovery EffortsA shattering champagne bottle christened the delivery of a $5 million, 7.5-ton magnet to Vanderbilt University's Center for Structural Biology. The magnet is the main part of an ultra-high field, 900 megahertz nuclear magnetic resonance (NMR) spectrometer that will help researchers solve the mysteries of cancer, Alzheimer's disease and other diseases. Standing 9.5 feet tall, the nearly six-foot wide white cylinder was gingerly lowered by crane through an opening in the roof of the Biomolecular NMR Facility - with just four inches of clearance. Once it's up and running this summer, the powerful spectrometer will be one of about 10 in the United States, but its intended use at Vanderbilt in cancer drug discovery may be unique, faculty members said. Read the whole Reporter article here News posted by veronda.mcclain@vanderbilt.edu: Jessica Vey, MBTP/CSB Seminar - 5/24/11Jessica Vey presents: “Structure-function studies of nitrososynthase: using protein rational design in biotechnology”, MRBIII, Room 1220, 12:30pm News posted by sonia.n.leggs@vanderbilt.edu: Congratulations to Dr. Jens MeilerThe CSB would like to congratulate Dr. Jens Meiler for his recent promotion to Associated Professor with tenure. News posted by sonia.n.leggs@vanderbilt.edu: Recognition for the Stewart LabRobert Kim and Justin Flatt in the Stewart laboratory have both been selected to give talks at the 2011 Microscopy and Microanalysis meeting in August, hosted by the Microscopy Society of America (MSA). In conjunction with this, Robert Kim was also selected as one of the 2011 MSA Presidential Student Awardees. The award includes an awards ceremony at the meeting, invitation to the Presidents' reception, fully paid registration for the meeting, and travel and lodging stipends. News posted by sonia.n.leggs@vanderbilt.edu: Vanderbilt University Receives 900MHz Nuclear Magnetic Resonance InstrumentOn Saturday, May 7, 2011, at approximately 8:00 a.m., Vanderbilt University will receive its new, ultra high-field 900 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The 7-1/2 ton instrument will be delivered to the Vanderbilt campus by crane, which will then hoist the 9-1/2 foot tall instrument and lower it through a 72 inch opening in the roof of the Biomolecular NMR Facility on campus. The addition of this instrument is key to maintaining Vanderbilt’s established position as the leading international center for biomolecular NMR research. News posted by sonia.n.leggs@vanderbilt.edu: Ralf Mueller - Dissertation of Defense, 05/04/2011Ralf Mueller of Meiler Lab presents, "Machine Learning Algorithms for Prediction of Biological Activity and Chemical Properties", at the Stevenson Center, Room 5502, 3:15 pm - 4:15 pm. News posted by sonia.n.leggs@vanderbilt.edu: Shane Hutson, MBTP/CSB Seminar - 05/03/2011Shane Hutson Ph.D., presents “Measuring the cell-level mechanics that drive tissue-level morphogenesis”, in the Medical Research Building III, Room 1220, at 12:30 pm. News posted by sonia.n.leggs@vanderbilt.edu: Chemistry Symposium - April 28, 2011The University of Melbourne and Vanderbilt University will host a joint Chemistry Symposium on April 28, 2011. It will be held at the Scarritt Bennett Center. No FEE to attend the symposium however Registration is required. To register and for information contact Rachel Poss via email, rachel.e.poss@vanderbilt.edu. Registration deadline is April 14, 2011. Click here for a the agenda (PDF format). News posted by sonia.n.leggs@vanderbilt.edu: New Graduate Course Announcement, CHEM 337 - Fall 2011Jens Meiler will be teaching a new graduate course CHEM 337 - "computational structural and chemical biology" in Fall 2011. The course covers theoretical and practical aspects of protein sequence alignments, secondary structure prediction, comparative modeling, protein-protein and protein-ligand docking. Further it includes structure-based drug design, virtual screening, quantitative structure activity relations, cheminformatics, and pharmacophore mapping in therapeutic development. This is a 4-credit course with a laboratory section where students are trained in the practical application of respective software tools. Undergraduate students wishing to take CHEM 337 for credit must complete CHEM 231 - "biophysical chemistry" first. News posted by sonia.n.leggs@vanderbilt.edu: Dr. Jeanne Hardy - Guest Speaker, Micro and Immunology Seminar SeriesThis Tuesday, April 5th, Jeanne Hardy will be giving a seminar in the Micro and Immunology Seminar Series entitled Suicidal Shape Shifters: Conformational control and real-time monitoring of caspase proteolytic activity. The seminar, which is co-sponsored by the Center for Structural Biology, will describe efforts to understand and engineer the activity of caspases involved in apoptosis. Dr. Hardy is an Assistant Professor of Chemistry at the University of Massachusetts in Amherst. She has an interesting background in structural biology, protein engineering, and design. In addition to the science, students may be interested in Dr. Hardy's training path - she did post-docs both in Japan and industry. The seminar will be held in MRB3 1220 at 3PM and all are welcome to attend. News posted by sonia.n.leggs@vanderbilt.edu: Andrew Morin - Dissertation of Defense, 04/25/2011Andrew Morin of Meiler's Lab presents, "Computational Design of Protein-Ligand Interfaces for Protein Therapeutic Discovery", at Medical Research Building III, Room 1220, 2:00 - 3:00 pm. News posted by sonia.n.leggs@vanderbilt.edu: Stephanie Hirst, MBTP/CSB Seminar - 04/19/2011Stephanie Hirst - Meiler Lab presents RosettaEPR: An Integrated Tool for Protein Structure Determination from Sparse EPR Data, Medical Research Building III, Room 1220, at 12:30pm. News posted by sonia.n.leggs@vanderbilt.edu: Mike Stone, MBTP/CSB Seminar - 04/05/2011Mike Stone presents, "DNA Damage Arising From Reactive Aldehydes", in the Medical Research Building III, Room 1220, at 12:30 pm. News posted by sonia.n.leggs@vanderbilt.edu: Julia Koehler, MBTP/CSB Seminar - 03/29/2011Julia Koehler presents: "Challenges in method development for membrane protein structure determination", in the Medical Research Building III, Room 1220, at 12:30 pm. News posted by sonia.n.leggs@vanderbilt.edu: David Nannemann - Dissertation Defense, 03/25/2011David Nannemann of Meiler's Lab presents, "Directed Biosynthesis of the Nucleoside Analog Drug Didanosine", at the Stevenson Center, Room 5502, 2:00 pm. News posted by sonia.n.leggs@vanderbilt.edu: William Schief, MBTP/CSB Seminar - 3/22/2011William Schief presents: “Structure-based Immunogen Design” MRBIII, Room 1220, 12:30pm News posted by sonia.n.leggs@vanderbilt.edu: Dr. Jens Meiler, Ph. D., DBMI Seminar - 03/16/2011Dr. Jens Meiler, Ph. D., Assistant Professor of Chemistry, will review a new protein folding algorithm that predicts the structure of large and complex proteins through assembly of secondary structure elements. Dr. Meiler will introduce a method for the simultaneous prediction of membrane protein secondary structure and transmembrane segments. Also, Dr. Meiler will combine both techniques for membrane protein folding de novo and guided by sparse NMR distance restraints. In addition, Dr. Meiler will discuss de novo high-resolution protein structure determination from sparse spin-labeling EPR data and atomic-detail protein structure prediction for proteins of up to 250 residues guided by cryo-EM density maps. News posted by sonia.n.leggs@vanderbilt.edu: Kyle Nordquist - Dissertation Defense, 03/22/2011KYLE ANDREW NORDQUIST,DEPARTMENT OF BIOCHEMISTRY VANDERBILT UNIV. SCH. OF MED., presents, " Structural and functional analysis of the U-box domain of the E4B ubiquitin ligase”, on March 22, 2011, 512 Light Hall, 1:00 pm News posted by sonia.n.leggs@vanderbilt.edu: Identification of glaucoma gene brightens future for therapiesA team of investigators from Vanderbilt University and the University of Florida has identified a new candidate gene for the most common form of the eye disorder, primary open angle glaucoma (POAG). The Reporter indentified Dr. Tina Iverson, one of the CSB Core Faculty members, as one of the collaborators in this research project. For more information, go to http://www.mc.vanderbilt.edu/reporter/index.html?ID=10261 News posted by sonia.n.leggs@vanderbilt.edu: Paul Barrett, MBTP/CSB Seminar - 3/15/2011Paul Barrett of the Sanders Lab presents: "Exploring Alzheimer's Disease From the Membrane Up; A Structural Biology Investigation using Nuclear Magnetic Resonance Spectroscopy" MRBIII, Room 1220, 12:30 pm News posted by sonia.n.leggs@vanderbilt.edu: Chemistry Symposium Coming Soon!!!University of Melbourn Australia and Vanderbilt University will host a joint Chemistry Symposium April 28, 2011. More information coming soon. Please mark your calendars, as many talks are likely to be of general interest to CSB members. News posted by sonia.n.leggs@vanderbilt.edu: Martin Karplus, Ph.D., MBTP/CSB Seminar - 03/21/2011Martin Karplus, Ph.D., Department of Chemistry and Chemical Biology, Harvard University and Laboratoire de Chimie Biophysique, ISIS, Université Louis Pasteur, presents:"How Proteins Work: Insights from Simulations" Martin Karplus is known for pushing forward the frontier of theoretical chemistry while at the same time keeping close contact with experimental developments. He enhanced our understanding of nuclear spin-spin coupling. The well-known Karplus equation, which deals with the angular dependence of vicinal proton coupling in NMR specta, has been important for conformational analysis of organic molecules and of the secondary structure of proteins. In another area, he was among the first to apply classical dynamic calculations to gas-phase chemical reactions, particularly relevant to the study of crossed molecular beams. His later research deals with theoretical studies on molecules of biological interest. Among these are calculations on the ground and excited states of the visual pigment retinal, on motional processes in proteins including side-chain rotations, opening and closing of active site clefts, and entrance and exit of oxygen from the binding site of myoglobin, and on nucleic acids. He has published over 500 articles. News posted by sonia.n.leggs@vanderbilt.edu: Aliquots — research highlights from VUMC laboratoriesDr. Martin Egli was feature in the Reporter 2/17/2011, Fluorine aids gene silencing RNA interference (RNAi), a cellular mechanism for regulating gene expression found in nearly all organisms, can be exploited for research and medical purposes. Synthetic double-stranded RNA molecules called short interfering RNAs (siRNAs) are used in such applications to silence gene expression, but the therapeutic potential of siRNAs is limited because the molecules are not “drug-like.” Martin Egli, Ph.D., and colleagues are investigating how chemical modifications affect the efficacy of siRNAs. In papers published recently in Angewandte Chemie and Nucleic Acids Research, they report on the promising properties of siRNAs modified with fluorine (2’-F siRNAs). To read more, http://www.mc.vanderbilt.edu/reporter/index.html?ID=10232 News posted by veronda.mcclain@vanderbilt.edu: Al Beth, MBTP/CSB Seminar - 3/1/11Al Beth presents: “Structure and Dynamics of the Ca2+ Binding Domain of the Cardiac Na+/Ca2+ Exchanger” MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Julia Koehler, MBTP/CSB Seminar - 03/29/11Julia Koehler presents: "Challenges in method development for membrane protein structure determination", MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Heidi Hamm, MBTP/CSB Seminar - 2/1/11Heidi Hamm, Ph.D. presents: "Receptor-mediated G protein activation" MRBIII, Room 1220, 12:30pm News posted by sonia.n.leggs@vanderbilt.edu: Grant Bolsters Pancreatic Cancer ResearchCSB would like to recognize Dr. Stephen Fesik of Biochemistry, Pharmacology and Chemistry in receiving a $2.5 million grant to fund research to develop drugs for treatment of pancreatic cancer. For more information, http://www.mc.vanderbilt.edu/reporter/index.html?ID=10108 News posted by veronda.mcclain@vanderbilt.edu: William Wan, MBTP/CSB Seminar - 1/25/11William Wan presents: “Structural Polymorphism of the Fungal Prion HET-s" MRBIII, Room 1220, 12:30pm News posted by Sonia.N.Leggs@vanderbilt.edu: AAAS honors seven Vanderbilt faculty membersThe VUMC Reporter reported the AAAS honors seven Vanderbilt faculty members. We would like to recognize, Stephen Fesik, Ph.D. and Michael Stone, Ph.D., both are CSB Core Faculty Members from the Biochemistry Department. Read more at, http://www.mc.vanderbilt.edu/reporter/index.html?ID=9999 News posted by Sonia.N.Leggs@vanderbilt.edu: Emily Rubinson - Dissertation of Defense 01/28/2011Emily Rubinson of the Eichman's Lab will present, " Structural and Biochemical Studies of Alkylpurine DNA Glycosylase AlkD" on January 28, 2011, Medical Research Building III, Room 1220 at 2:00 pm - 3:00 pm News posted by veronda.mcclain@vanderbilt.edu: Dave Piston, MBTP/CSB Seminar - 1/4/11Dave Piston, Ph.D. presents: “Imaging the Molecular Mechanisms Underlying Glucose-Stimulated Insulin Secretion” MRBIII, Room 1220, 12:30pm News posted by Sonia.N.Leggs@vanderbilt.edu: Kelsey Constance Duggan - Dissertation Defense 12/06/2010Kelsey Constance Duggan from Dr. L.J. Marnett's Lab, presents "Structural and Functional Analysis of Cyclooxygenase-2 Inhibition by Non-Steroidal Anti-Inflammatory Drugs", Monday, December 6, 2010, at 1:00 p.m., Preston Research Building, room 206 News posted by veronda.mcclain@vanderbilt.edu: Daniel Liebler, MBTP/CSB Seminar - 12/7/10Daniel Liebler, Ph.D. presents: “Discrimination of cancer phenotypes by proteomic technology platforms”, MRBIII, Room 1220, 12:30pm News posted by Sonia.N.Leggs@vanderbilt.edu: Grant bolsters study of human B cellsDr. James Crowe Jr., M.D., is recognized in the Reporter for winning a five year, $5.3 million NIH grant to study the human B cell and to find new approaches to designing vaccines. Both Dr. Jens Meiler, Ph.D., and Dr. Ben Spiller, Ph.D., will collaborate and contribute to this project. Their expertise is in computational modeling and x-ray crystallography. To read more, go to http://www.mc.vanderbilt.edu/reporter/index.html?ID=7796 News posted by Sonia.N.Leggs@vanderbilt.edu: Congratulations to Richard Armstrong - The Repligen Award in Chemistry of Biological ProcessesProfessor Richard Armstrong is the recipient of the 2011 Repligen Award in Chemistry of Biological Processes. We want to recognize Professor Armstrong's contributions of specfically understanding structure, function and mechanism detoxification enzymes within a cell. In addition, Professor Armstrong will present a lecture as part of a symposium, in the Fall 2011 ACS National Meeting. To read more, http://www.divbiolchem.org/awards/recipients News posted by Sonia.N.Leggs@vanderbilt.edu: Sylvain Le Marchand - Dissertation Defense - 12/7/2010Sylvain Le Marchand, mentored by David W. Piston, presents “Mechanisms of glucagon secretion in mouse pancreatic α-cells”. On Tuesday, December 7, 2010, 10:00 am, Light Hall, Room 208 News posted by veronda.mcclain@vanderbilt.edu: Sarah Soss, MBTP/CSB Seminar - 11/16/10Sarah Soss presents: "Who's the Boss in Ubiquitination?" MRBIII, Room 1220, 12:30pm News posted by jessica.greer@vanderbilt.edu: Thomas Tomasiak - Dissertation DefenseCatalysis and inhibition in menaquinol:fumarate oxidoreductase". Location: 206 Preston Research Building on 11/23/2010 from 10:00 AM - 11:00 AM. News posted by veronda.mcclain@vanderbilt.edu: Niels De Jonge, MBTP/CSB Seminar - 11/2/10Niels De Jonge presents: "Imaging tagged proteins in whole cells with liquid and 3D STEM" MRBIII, Room 1220, 12:30pm News posted by jessica.greer@vanderbilt.edu: Leipzig-Vanderbilt CollaborationOn November 10th, at 1:30pm, in 208 Light Hall there will be a "Special Symposium Leipzig Vanderbilt Collaboration". Eight faculty from Leipzig University will be visiting and present their research. News posted by veronda.mcclain@vanderbilt.edu: Dewight Williams, MBTP/CSB Seminar - 10/26/10Dewight Williams presents: "EM imaging reveals assembly states of a cyanobacterial protein, a nano-clock that drives circadian gene expression" MRBIII, Room 1220, 12:30pm News posted by jessica.greer@vanderbilt.edu: Steffen Lindert - Dissertation Defense - 11/22/2010Steffen Lindert will present "CryoEM guided de-novo protein folding" at 2:00pm, MRBIII, RM-1220, on Monday, November 22, 2010. News posted by sonia.n.leggs@vanderbilt.edu: Dr. Brandt Eichman and Emily Rubinson in the ReporterDr. Brandt Eichmand and Emily Rubinson were featured in the Reporter on October 7, 2010 for their contribution to "New mechanism for DNA repair discovered." Tucked within its double-helix structure, DNA contains the chemical blueprint that guides all the processes that take place within the cell and are essential for life. Therefore, repairing damage and maintaining the integrity of its DNA is one of the cell’s highest priorities. To review this article, http://www.mc.vanderbilt.edu/reporter/index.html?ID=9551 News posted by sonia.n.leggs@vanderbilt.edu: Timothy Panosian Dissertation Defense - 11/12/2010TIMOTHY PANOSIAN of Tina Iverson’s lab, will present "A structural foundation for utilizing Bacillus cereus phosphopentomutase in the synthesis of didanosine" at 10:00 am, Light Hall, room 512, on Friday, November 12, 2010. News posted by sonia.n.leggs@vanderbilt.edu: Yoana Nantcheva Dimitrova Dissertation Defense - 10/13/2010Yoana Nantcheva Dimitrova of Dr. Chazin Lab will present, "Biochemical and Structural Analyses of TBL1: Insights into the Function of a Transcriptional Regulator" at Light Hall, Room 214, Wednesday, October 13, 2010 at 2:00 pm. News posted by veronda.mcclain@vanderbilt.edu: Andrej Sali, Invited Speaker - MBTP/CSB Seminar 10/12/10Andrej Sali, Ph.D., Bioengineering and Therapeutic Sciences-UCSF, presents: "Computational Integration of Diverse Structural and Kinetic Data for Visualizing Macromolecular Assemblies and Processes" MRBIII, Room 1220, 12:30pm News posted by sonia.n.leggs@vanderbilt.edu: Latest published articles from the Eichman's Group in NatureCongratulations to Dr. Brandt Eichman and Emily H. Rubinson for their contribution in the latest published article entitled, “An unprecedented nucleic acid capture mechanism for excision of DNA damage”. DNA glycosylases that remove alkylated and deaminated purine nucleobases are essential DNA repair enzymes that protect the genome, and at the same time confound cancer alkylation therapy, by excising cytotoxic N3-methyladenine bases formed by DNA-targeting anticancer compounds. The basis for glycosylase specificity towards N3- and N7-alkylpurines is believed to result from intrinsic instability of the modified bases and not from direct enzyme functional group chemistry. Here we present crystal structures of the recently discovered Bacillus cereus AlkD glycosylase in complex with DNAs containing alkylated, mismatched and abasic nucleotides. Unlike other glycosylases, AlkD captures the extrahelical lesion in a solvent-exposed orientation, providing an illustration for how hydrolysis of N3- and N7-alkylated bases may be facilitated by increased lifetime out of the DNA helix. The structures and supporting biochemical analysis of base flipping and catalysis reveal how the HEAT repeats of AlkD distort the DNA backbone to detect non-Watson–Crick base pairs without duplex intercalation. For more information, http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09428.html News posted by veronda.mcclain@vanderbilt.edu: Jens Meiler, MBTP/CSB Seminar - 10/5/10Jens Meiler, presents: “Protein Structure Determination from Sparse Experimental Data- and -Design of a Sequence-Symmetric TIM Barrel Protein” MRBIII, Room 1220, 12:30pm News posted by Sonia.N.Leggs@vanderbilt.edu: Dr. Stephen W. Fesik receives NIH Director's Pioneer AwardAs was announced in the Reporter (http://www.mc.vanderbilt.edu/reporter/index.html?ID=9245), Dr. Stephen W. Fesik will be introduced as a recipient of the NIH Director's Pioneer Award (first from Vanderbilt) at the Sixth Annual NIH Director's Pioneer Award Symposium next Thursday, September 30, 2010 in Bethesda, MD. The introduction of the 2010 Pioneer awardees will take place at the start of the symposium at about 8:30 a.m. EST (7:30 a.m. CST). A live videocast will be available at http://videocast.nih.gov. A day or two after the symposium, the event will also be available for viewing on the videocast archive at http://videocast.nih.gov/PastEvents.asp. News posted by veronda.mcclain@vanderbilt.edu: Kelli Kazmier, MBTP/CSB Seminar - 9/21/10Kelli Kazmier presents: "EPR Restrained Computational Modeling: Developing a Restraint Selection Algorithm" MRBIII, Room 1220, 12:30pm News posted by sonia.n.leggs@vanderbilt.edu: Congratulations to Dr. Richard ArmstrongThe Center for Structural Biology would like to recognize and congratulate Dr. Richard Armstrong for being the recipient of the 2011 Repligen Award from the American Chemical Society. News posted by sonia.n.leggs@vanderbilt.edu: Congratulations to Dr. Charles R. SandersDr. Chuck Sanders received one of the five 2010 Chancellor's Awards for Research on Thursday,August 26, 2010. Dr. Sanders published the structure of diacyglycerol kinase, an integral membrane protein, in a Science paper last year using solution NMR spectroscopy. This was the largest membrane protein structure solved by NMR to date. News posted by sonia.n.leggs@vanderbilt.edu: ‘Glue grant’ to enhance study of membrane proteinsThe Reporter quotes Dr. Hasssane Mchaourab, “This is a tremendous opportunity to combine the expertise of experimentalists and theoreticians to take on the 'grand challenge' of defining the mechanisms through which conformational dynamics impart function to key membrane protein classes”. Read More at http://www.mc.vanderbilt.edu/reporter/index.html?ID=9278 News posted by veronda.mcclain@vanderbilt.edu: John McLean, MBTP/CSB Seminar - 9/7/10John McLean presents: "Advanced structural mass spectrometry for systems biology – pulling the needles from haystacks" MRBIII, Room 1220, 12:30pm News posted by Sonia.N.Leggs@vanderbilt.edu: Primase structure gives insight into DNA replicationThe Reporter recognized Dr. Walter Chazin, Ph.D., Dr. Sivaraja Vaithiyalingam, Ph.D., and Dr. Brandt Eichman, Ph. D. for their efforts of studying a protein that helps initiates DNA replication. See More http://www.mc.vanderbilt.edu/reporter/index.html?ID=9246 News posted by Sonia.N.Leggs@vanderbilt.edu: Congratulations to Dr. Stephen FesikDr. Stephen Fesik has received the National Institutes of Health Director's Award. Read more: http://www.mc.vanderbilt.edu/reporter/index.html?ID=9245 News posted by veronda.mcclain@vanderbilt.edu: Suraj Adhikary, MBTP/CSB Seminar 8/17/10Suraj Adhikary presents: "Structural insights into DNA damage selection" MRBIII, Room 1220, 12:30pm News posted by sonia.n.leggs@vanderbilt.edu: Congratulations to William WanAt the annual meeting of the American Crystallographic Association in Chicago last week, William Wan (CPB program graduate student in Gerald Stubbs’s lab) received the Margaret C. Etter Student Lecturer award for his presentation in the Fiber Diffraction Special Interest Group session. News posted by veronda.mcclain@vanderbilt.edu: Edward Prage, MBTP/CSB Seminar 8/3/10Edward Prage presents: "Location of inhibitor binding sites within the inducible PGE synthase, MPGES1" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Walter Chazin, MBTP/CSB Seminar - 7/13/10Walter Chazin presents: “What's all the excitement about SAXS?” MRBIII, Room 1220, 12:30pm News posted by Sonia.N.Leggs@vanderbilt.edu: Kristian Kaufmann Dissertation Defense - 6/30/2010Kristian Kaufmann presents, "Computational Prediction of Small Molecule Protein Interfaces Using Rosetta", June 30th, 2010 at the Stevenson Building, Room 5502, 2:00 pm. News posted by Sonia.N.Leggs@vanderbilt.edu: Kelly Ann Gangwer Dissertation Defense - 7/1/2010Kelly Ann Gangwer, Graduate Student From the laboratory of Dr. D. Borden Lacy 7/1/2010 1:30pm 1220 MRBIII “Structural, Functional, and Phylogenetic Analysis of the Helicobacter Pylori Vacuolating Cytotoxin (VacA)” Helicobacter pylori is a gram-negative bacterium that contributes to the pathogenesis of peptic ulcer disease and gastric cancer. A key virulence factor for the organism is vacuolating cytotoxin A (VacA), a pore-forming toxin that causes multiple alterations in human cells. The toxin is secreted by an autotransporter pathway as an 88 kDa protein which can be divided into two structural domains; a 33 kDa domain (p33) responsible for pore formation and a genetically diverse 55 kDa domain (p55) associated with receptor binding. We hypothesize that structural, functional and phylogenetic analyses will allow us to assess the mechanism by which VacA interacts with host cells. Using X-ray crystallography, we found that the VacA m1 p55 domain adopts a β-helix fold, a feature that is characteristic of autotransporter passenger domains but unique among known bacterial protein toxins. Notable features of VacA p55 include disruptions in β-sheet contacts that result in five β-helix sub-domains and a novel C-terminal domain. The elongated β-helical structure of VacA presents a unique opportunity for studying the pressures of positive and negative selection in a structural context. We have demonstrated that amino acid substitutions in the VacA p55 domain are under strong, diversifying selection. Docking the p55 structure into a 19 Å cryo-EM map of a VacA dodecamer allows us to propose a model for how VacA monomers assemble into oligomeric structures capable of membrane channel formation. We have recently been able to reconstitute this activity from a mixture of p55 and p33 added together in trans. This advance provides a tractable avenue for future studies aimed at obtaining high resolution structural information for VacA p33. News posted by veronda.mcclain@vanderbilt.edu: Martin Egli, MBTP/CSB Seminar - 6/15/10Martin Egli presents: “Temperature Compensation in the KaiABC Clock” and “Unique Properties of 2'-Fluoro Modified siRNAs” MRBIII, Room 1220, 12:30pm News posted by Sonia.N.Leggs@vanderbilt.edu: Bruker Announces Major Multi-Systems NMR Order from Vanderbilt UniversityBillerica, Massachusetts, May 20, 2010 – Bruker, the leader in analytical magnetic resonance instrumentation, announces a major multi-systems NMR order from Vanderbilt University, including an ultra-high field AVANCE™ III 900 US2 NMR spectrometer. This purchase was made possible in large part by the American Recovery and Reinvestment Act. Vanderbilt will use these NMR instruments for a broad range of biophysical and structural analyses in biomedical research, as well as for cancer drug discovery using fragment-based approaches and structure-based drug design. For more information, http://www.bruker-biospin.com/pr100520.html News posted by veronda.mcclain@vanderbilt.edu: Jessica Mazerik, MBTP/CSB Seminar - 6/1/10Jessica Mazerik presents: “Dissecting the mechanism of myo1a membrane binding” MRBIII, Room 1220, 12:30pm News posted by sonia.n.leggs@vanderbilt.edu: Meningitis protein structure reveals immune response ‘spark’Dr. Tina Iverson's latest research on the Meningitis protein structure is featured in the Vanderbilt Reporter. Please click here for more info : <a href="http://www.mc.vanderbilt.edu/reporter/index.html?ID=8790">http://www.mc.vanderbilt.edu/reporter/index.html?ID=8790</a>. News posted by veronda.mcclain@vanderbilt.edu: Volker Dötsch, Guest Speaker, MBTP/CSB Seminar - 5/4/10Volker Dötsch presents: “Combination of Cell-free Expression and NMR for the Structure Determination of the c-Terminal Domain of presenilin” MRBIII, Room 1220, 12:30pm News posted by walter.chazin@vanderbilt.edu: Latest paper from the Iverson group in PNASCongratulations to Tina, Mikio and Crina for getting their recent work published in PNAS!! Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB Mikio Tanabe, Crina M. Nimigean, and T. M. Iverson PNAS April 13, 2010 vol. 107 no. 15 6811-6816 News posted by veronda.mcclain@vanderbilt.edu: Anne Kenworthy, MBTP/CSB Seminar - 4/20/10Anne Kenworthy presents: “Quantitative analysis of molecular dynamics and binding kinetics in living cells by fluorescence recovery after photobleaching.” MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Join us for "Naturally Obsessed"- A Laboratory Science Documentary 5/21/10Naturally Obsessed: the making of a scientist opens a penetrating view of what it takes to become a scientist. Drawn from three years of filming in a single laboratory, the film focuses on a group of irrepressible graduate students working towards the PhD degree, and their mentor, a tough but genial young professor. MRBIII, Room 1220, 3:00-4:30pm News posted by veronda.mcclain@vanderbilt.edu: Steffen Lindert, MBTP/CSB Seminar - 4/6/10Steffen Lindert presents: “BCL::EM-Fold: Protein Folding into medium resolution density maps” MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Eric Hustedt, MBTP/CSB Seminar - 3/23/10Eric Hustedt presents: "Lessons learned from site-directed spin-labeling of the cytoplasmic domain of band 3 protein" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Rajalakshmi Nambiar, MBTP/CSB Seminar - 3/2/10Rajalakshmi Nambiar presents: “Control of Membrane Tension by a Molecular Motor” MRBIII, Room 1220, 12:30pm News posted by walter.chazin@vanderbilt.edu: CSB investigators to speak at structural biology symposiumOur very own Brandt Eichman and Martin Egli will be giving an invited lecture at the Advances in Structural Biology symposium at the Danforth Center in St. Louis in September. For more information check the website at: http://www.danforthcenter.org/fallsymposium2010/flyer.htm News posted by veronda.mcclain@vanderbilt.edu: Ryoma Ohi, MBTP/CSB Seminar - 2/16/10Ryoma Ohi presents: “Motor function during mitosis and meiosis” MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Charles Day, MBTP/CSB Seminar - 2/2/10Charles Day presents: “Probing mechanisms of plasma membrane microdomain formation by Cholera Toxin” MRBIII, Room 1220, 12:30pm News posted by joel.harp@vanderbilt.edu: Galina Lepesheva publishes Paper of the Week in JBCThe current issue of the Journal of Biological Chemistry contains a paper by Galina Lepesheva and co-authors on the structure of Trypanosoma brucei sterol 14alpha-demethylase. The paper was chosen Paper of the Week. The structure also graces the journal cover. Papers of the Week are chosen by the journal Associate Editors and Editorial Board members and represent the top 1% of all reviewed papers. Galina is Research Associate Professor in the laboratory of Michael Waterman. News posted by veronda.mcclain@vanderbilt.edu: Larry Marnett, MBTP/CSB Seminar - 1/19/10Larry Marnett presents: “Four Thousand Years of Studying NSAIDs and We Might be Making Some Progress” MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Siva Vaithiyalingam, MBTP/CSB Seminar - 1/5/10Sivaraja Vaithiyalingam presents: “Towards a structural mechanism for DNA priming in higher eukaryotes: Insights from the structure of the unique DNA primase 4Fe-4S domain” MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Charles Sanders, MBTP/CSB Seminar - 12/15/09Charles Sanders presents: "Explaining The Cholesterol-Alzheimer's Disease Connection: A Biophysically-Derived Hypothesis" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Gordon Lemmon, MBTP/CSB Seminar - 12/1/09Gordon Lemmon presents: “Improved modeling of molecular flexibility leads to more accurate predictions of protein/small molecule interfaces” MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Stephen Fesik, MBTP/CSB Seminar - 11/17/09Stephen Fesik presents: "Discovery of IAP inhibitors for the treatment of cancer" 1220 MRBIII, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Gail Fanucci, Guest Speaker, MBTP/CSB Seminar - 11/10/09Gail Fanucci, University of Florida presents: “Pulsed EPR Studies of Protein Flexibility: Applications to HIV-1 Protease” 1220 MRBIII, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: CSB Gathering and Poster Session 10/30/09A special Friday afternoon gathering and poster session hosted by the Center for Structural Biology. Please join us for refreshments and poster presentations by CSB laboratories. 2:30-5pm, Fifth Floor MRBIII News posted by veronda.mcclain@vanderbilt.edu: Center for Structural Biology OPEN HOUSE 10/30/09SPEAKERS: Billy Hudson, Ph.D., Director of the Center for Matrix Biology Departments of Medicine, Pathology, and Biochemistry “Kidney Filtration Apparatus and the Discovery of the Sulfilimine Bond” Craig Lindsley, Ph.D., Director of Medicinal Chemistry and Vanderbilt Specialized Chemistry Center for Accelerated Probe Development Departments of Pharmacology and Chemistry “Probe Development” Commons Center Room 237, Peabody Campus, 1-2:30PM News posted by veronda.mcclain@vanderbilt.edu: Megan Wadington, MBTP/CSB Seminar - 11/3/09Megan Wadington presents: "Discovery of Enzyme Function in the Glutathione Transferase Superfamily from Escherichia coli K-12" MRBIII, Room 1220, 12:30pm News posted by sabuj.pattanayek@vanderbilt.edu: Stubbs lab study on prions featured in VU ExplorationThe Stubbs lab study on prions is featured in the most recent VU Exploration online magazine: http://www.vanderbilt.edu/exploration/stories/prions.html . News posted by veronda.mcclain@vanderbilt.edu: Andrzej Krezel, MBTP/CSB Seminar 10/20/09Andrzej Krezel presents: "Structural Biology of Transcription in Helicobacter pylori" 1220 MRBIII, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Gerald Stubbs, MBTP/CSB Seminar 10/6/09Gerald Stubbs presents: “Natural and synthetic prion structure from X-ray fiber diffraction” MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Jessica Vey, MBTP/CSB Seminar - 9/15/09Jessica Vey presents: "Structural Basis for Glycyl Radical Formation by Pyruvate Formate-lyase Activating Enzyme" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Wade Van Horn, MBTP/CSB Seminar - 9/1/09Wade Van Horn presents: "Solution NMR Structure of Membrane-Integral Diacylglycerol Kinase" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Patrick Robertson, MBTP/CSB Seminar 8/18/09Patrick Robertson presents: “Solution NMR Structure of the C-Terminal Domain of Xenopus laevis Mcm10 Reveals a Novel Zn2 DNA Binding Motif” MRBIII, Room 1220, 12:30pm News posted by jsmith@structbio.vanderbilt.edu: CSB News Now Available via Twitter!Follow "VanderbiltCSB" to have CSB news sent directly to your Twitter timeline. News posted by veronda.mcclain@vanderbilt.edu: Ben Spiller, MBTP/CSB Seminar 8/4/09Ben Spiller presents: "VirA, Shigella, and the Host Cytoskeleton" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Christina Williams, MBTP/CSB Seminar 7/21/09Christina Williams presents: "Structural and Dynamic Analysis of SV40 J domain Interactions” MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Mariena Silvestry Ramos, Dissertation Defense, 7/9/09"Insight into Adenovirus Programmed Disassembly From CryoEM: The Structures of Ad2ts1 and the Ad35f+Defensin HD5 Complex" Thursday, July 9, 2009, 10:00 a.m. 202 Light Hall News posted by walter.chazin@vanderbilt.edu: Major breakthrough for the Sanders LabChuck Sanders and his group have completed the solution NMR structure of DAGK. The work is published in the latest issue of Science. See the press release at: http://www.mc.vanderbilt.edu/news/releases.php?release=940 Congratulations on this wonderful achievement!! News posted by veronda.mcclain@vanderbilt.edu: Andrzej Krezel, MBTP/CSB Seminar Series 7/7/09Andrzej Krezel presents: "Structural Biology of Transcription in Helicobacter pylori" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Sarah Musser, MBTP/CSB Seminar 6/16/09Sarah Musser presents: "Structural Investigations of Stereoisomeric N3-deoxyuridine DNA Adducts Arising from Butadiene Monoepoxide" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Borden Lacy, MBTP/CSB Seminar Series 6/2/09Borden Lacy presents: Bacterial protein toxin entry into host cells: Mechanisms of pore formation and translocation MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Tim Panosian, MBTP/CSB Seminar 5/19/09Tim Panosian presents: Move it move it; the structure and mechanism of a phosphopentomutase MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Andrew Link, MBTP/CSB Seminar Series 5/5/09Andrew Link presents: Systematic Proteomic Analysis of Eukaryotic Translation Complexes MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Diane Kanter, MBTP/CSB Seminar Series 4/21/09Diane Kanter presents: The role of Dpb11 in DNA metabolism MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Tina Iverson, MBTP/CSB Seminar Series 4/7/09Tina Iverson presents: "The outer membrane protein PorB from Neisseria meningitidis: from structure to function to disease" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Dalyir Pretto, MBTP/CSB Seminar Series 3/17/09Dalyir Pretto presents: "InvestigatingDomain Flexibility and Intersubunit interactions in Replication Protein A" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Phoebe Stewart, MBTP/CSB Seminar Series 3/3/09Phoebe Stewart presents: "Visualizing the Structures and Conformational Changes of Biological Nanomachines with CryoEM" MRBIII, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Emily Rubinson MBTP/CSB Seminar Series 2/17/09Emily Rubinson presents: "A New Architecture for Locating and Excising Alkylpurines from DNA: The Crystal Structure of DNA Repair Protein AlkD" MRBIII, Room 1220, 12:30pm News posted by walter.chazin@vanderbilt.edu: Eichman wins Sigma Xis Young Investigator AwardBrandt Eichman was named the winner of the 2008 Sigma Xi Award to recognize research excellence within ten years of earning his or her highest degree. See link at: http://sitemason.vanderbilt.edu/news/releases/2009/01/29/vanderbilt-biochemist-receives-2009-sigma-xi-award.71862 News posted by veronda.mcclain@vanderbilt.edu: Laura Mizoue, MBTP/CSB Seminar Series 2/3/09Laura Mizoue presents: "In search of: hidden domains in the transcription factor HoxA11" MRB III, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Katie Germane MBTP/CSB Seminar Series 1/20/09Katie Germane presents: Structural and Functional Analysis of Shigella flexneri Virulence Factor VirA MRB III, Room 1220, 12:30pm News posted by veronda.mcclain@vanderbilt.edu: Symposium in Memory of Anne Karpay - 1/23/09Symposium in Memory of Anne Karpay: Gunning for Membrane Proteins January 23, 2009 2:30-5:30, 1220 MRBIII Speakers: James Bowie (UCLA), Douglas Rees (Caltech), Stanley Opella (UCSD) Karpay Symposium Poster News posted by veronda.mcclain@vanderbilt.edu: Paul Bock, MBTP/CSB Seminar Series 1/6/09Paul Bock presents: "Focusing on the Invisible Parts of the Mechanism of Plasminogen Activation by Streptokinase" MRBIII, Room 1220, 12:30pm News posted by jsmith@structbio.vanderbilt.edu: Eichman and Chazin research sheds new light on eukaryotic DNA replication machineryRecent research directed by Professor Brandt Eichman has elucidated some of the first atomic details of a protein involved in replicating DNA in eukaryotic organisms. Duplication of DNA each time a cell divides is one of the most fundamental processes in biology. However, due to the complexity and size of the multi-protein machine that drives DNA replication, the mechanisms by which eukaryotes orchestrate the synthesis of daughter from parental DNA is largely unknown. The Eichman lab determined the crystal structure of the DNA binding domain of one essential replisome component, Mcm10, and in collaboration with Walter Chazin and Anja Bielinsky (University of Minnesota), has uncovered the manner in which this domain interacts with DNA and its importance in replication. Featured on the cover of the December, 2008 issue of Structure (Cell Press), this research integrates X-ray crystallography, NMR spectroscopy, biochemistry, and yeast genetics, and will be an important starting point for understanding the details of one of natures most fundamental processes. Read More | Multimedia Version News posted by veronda.mcclain@vanderbilt.edu: Matt Tyska MBTP/CSB Seminar Series 12/2/08Matt Tyska presents: "A novel role for actin-based motor proteins in the regulation of cell membrane mechanics" MRB III, Room 1220, 12:30pm News posted by lori.michalowski@vanderbilt.edu: John Tainer, Ph.D. MBTP Guest Speaker, November 18,Guest Speaker John Tainer, Ph.D. Professor, Department of Molecular Biology and The Skaggs Institute for Chemical Biology presents: "XPD and Mre11/Rad50/Nbs1 ATPase Complexes: Structural Insights into the Cancer and Aging Phenotypes from Mutations of these Genome Guardians". Tuesday, November 18, 12:30pm MRB 3, Rm 1220. News posted by jsmith@structbio.vanderbilt.edu: Stubbs lab research could lead to new ways to improve crop yieldsA recent interdisciplinary study directed by Professor Gerald Stubbs has yielded the first detailed information about the structure of the most destructive group of plant viruses known: flexible filamentous viruses. The cost of worldwide crop losses due to plant diseases is estimated at $60 billion annually. Although there are no good estimates of the cost of plant viruses alone, the viruses are generally considered to be the second greatest contributor to those losses (after fungi). The 300-plus species of flexible filamentous viruses are responsible for more than half of all virus damage. The findings are published in the October 1 issue of the Journal of Virology and could lead to new ways to protect crop plants from these viruses. Read More | Multimedia Version News posted by lori.michalowski@vanderbilt.edu: MBTP/CSB Seminar Series Dave Piston, Ph.D. November 4, 2008Dave Piston presents: "Systems Biology of a Model Multicellular System" 12:20pm, MRB 3, Room 1220 News posted by lori.michalowski@vanderbilt.edu: David Eisenberg, DPhil. Bircher Lecture, October 27, 4:20pmDavid Eisenberg, DPhil presents: "Structural Biology of Amyloids and Prions". Refreshments at 4p in 7330A SC (the Chemistry Dept. Conference Room), and a reception to immediately follow the lecture, also in 7330A SC. News posted by lori.michalowski@vanderbilt.edu: Nathan Alexander MBTP/CSB Seminar Series 10/21/08Nathan Alexander of Jens Meiler Lab presents: "Incorporation of Experimental Restraints with Protein Structure Prediction". MRB 3, Room 1220. 12:20pm News posted by lori.michalowski@vanderbilt.edu: John Wikswo presents MBPT Seminar September 30 12:20John Wikswo presents: The possibility of automated, on-line inference of metabolic networks". Tuesday, September 30, 12:20 in MRB 3, Room 1220 News posted by lori.michalowski@vanderbilt.edu: Rory Pruitt Presents MBTP Seminar Series September 16Rory Pruitt of Borden Lacy Lab presents:"Structural and Functional Studies of Large Clostridial Cytotoxins" MRB 3, Room 1220, 12:15pm. News posted by lori.michalowski@vanderbilt.edu: Richard Armstrong presents MBTP lecture 9/9/08Richard Armstrong, Ph.D. Editor in Chief, Journal of Biochemistry Will lead a discussion on: "Ethics in Publication" All students actively supported by the MB training grant are required to attend this special seminar Tuesday, September 9, 2008 **NOTE TIME EXTENSION** 12:20 1:55pm Lunch available at 12:10 Seminar begins at 12:20 **MRB III, Room 1220** News posted by lori.michalowski@vanderbilt.edu: Dewight Williams, presents at MBTP Seminar 8/26/08Dewight Williams, Ph.D. presents: "The DNA-dependent protein kinase catalytic subunit structure determined by electron cryomicroscopy to < 10 Angstroms resolution." Tuesday, August 26, 2008 12:20 1:20pm Lunch available at 12:10 Seminar begins at 12:20 **MRB III, Room 1220** News posted by lori.michalowski@vanderbilt.edu: Liliana Wroblewska - TALK CANCELLED. News posted by lori.michalowski@vanderbilt.edu: Liliana Wroblewska Meiler, Post-doc candidate speaks 8/19, 12:20Molecular Biophysics Training Program Seminar Series / Center for Structural Biology Liliana Wroblewska Post-doc candidate Meiler Lab presents: "Refinement of protein models with all-atom force fields" Tuesday, August 19, 2008 12:20 1:20pm Lunch available at 12:00 Seminar begins at 12:20 **MRB III, Room 1220** News posted by lori.michalowski@vanderbilt.edu: MBTP/CSB Seminar Kristian Kaufman, 8/12, 12:20pm MRB 3, Room 1220Molecular Biophysics Training Program Seminar Series / Center for Structural Biology Kristian Kaufman Meiler Lab presents: "A Perspective on Computational Prediction of Interfaces Between Proteins and Small Molecules: Simultaneous Optimization of Protein Side Chain and Small Molecule Degrees of Freedom" Tuesday, August 12, 2008 12:20 1:20pm Lunch available at 12:00 Seminar begins at 12:20 MRB III, Room 1220 News posted by lori.michalowski@vanderbilt.edu: Brenda Schulman, talk August, 11, 2008, 4:00pmBrenda Schulman, Ph.D. Investigator, Howard Hughes Medical Institute Assoc. Member, St. Jude Childrens Research Hospital presents, Conformational Control in the dynamic Processes of Ubiquitin-Like Protein Conjugation Monday, August 11, 2008 4:00 5:00 pm Stevenson Center, Room 5502 News posted by walter.chazin@vanderbilt.edu: Iverson receives prestigous awardCongratulations to Tina Iverson, who has been selected to receive a Young Investigator award from the National Alliance for Research on Schizophrenia and Depression. This is for work to study the mechanisms for the sensing of dopamine. News posted by lori.michalowski@vanderbilt.edu: Gunter Fritz, Ph.D. presents CSB/MBTP Seminar 7/29/08Molecular Biophysics Training Program Seminar Series / Center for Structural Biology Guenter Fritz, Ph.D. Privat Dozent, Assistant Professor University of Konstanz, Germany Presents: Insights into receptor activation from structural biology of the receptor RAGE and its ligands Tuesday, July 29, 2008 12:00 1:00pm Lunch available at 11:45 Seminar begins at 12:00 **MRB III, Room 1220** News posted by walter.chazin@vanderbilt.edu: Meiler co-authors Science paper on conformational variabilityJens Meiler was part of a team that used residual dipolar couplings (RDCs)and computation to show the conformational variation of the small protein ubiquitin. This study demonstrates the power of using the RDC parameter to characterize slow conformational dynamics up to the msec time scale. The results were also significant in lending support to the concept that structural changes required for binding are already being sampled through the fluctuations of the free protein. News posted by lori.michalowski@vanderbilt.edu: Gunnar Jeschke, Ph.D. presents: Structural models of membrane proteins from pulsed EPR distance meaThe Center for Structural Biology, Department of Chemistry, and Molecular Physiology and BioPhysics are pleased to host: Gunnar Jeschke, Ph.D. ETH Zurich Laboratory for Physical Chemistry Who will present: Structural models of membrane proteins from pulsed EPR distance measurements Friday, August 1, 2008 11:30 12:30pm. Tentative Location: MRB 3, Room 1220 News posted by lori.michalowski@vanderbilt.edu: Tennessee Structural Biology SymposiumTennessee Structural Biology Symposium begins with registration from 12:00 - 2:00 on Friday, June 20, 2008 in the Peabody Commons. Please see the website for additional information. http://structbio.vanderbilt.edu/TSBS5/ News posted by lori.michalowski@vanderbilt.edu: Benjamin Chagot presents the MBTP Seminar Series, June 17, 12:00pmHow do the intrinsic (EF-hand domain of hH1) and extrinsic (calmodulin) Ca2+ sensors regulate gating of the human cardiac sodium ion channel hH1?. SC 5502, 12:00pm - 1:30pm lunch served at 11:45. News posted by lori.michalowski@vanderbilt.edu: Chuck Mobley Defense, June 12, 2008 3:00 pm, SC5502"Biophysical Studies of Human Neuorolgical Membrane Proteins" News posted by lori.michalowski@vanderbilt.edu: Brian Weiner Defense; Monday, June 9, 2:00pm, 1220 MRB 3"Biochemical and structural analysis of the p58C and p68N domains of DNA polymerase alpha/primase". News posted by lori.michalowski@vanderbilt.edu: MBTP/CSB Seminar Larry MarnettLarry Marnett, Ph.D. presents: "Dynamics of Cyclooxygenase-Inhibitor Interactions - Origins of Potency and Selectivity of Binding" 12:00 in the Stevenson Center 5502 News posted by lori.michalowski@vanderbilt.edu: Tenneessee Structural Biology SympoisumThe 5th Annual TN Structural Biology Symposium will be held Friday, June 20th and Saturday, June 21st at the Peabody Commons. Please see the TN Structural Biology Symposium website for additional information at: http://structbio.vanderbilt.edu/TSBS5/ News posted by lori.michalowski@vanderbilt.edu: Update title of Miko Tanabe May 20 talk"Structural studies of the outer membrane porin PorB from Neisseria meningitidis" News posted by lori.michalowski@vanderbilt.edu: Miko Tanabe presents at MBTP May 20Miko Tanabe of the Iverson Lab Presents: Understanding pathogen recognition mechanism by TLRs the way to determine crystal structure of outer membrane porin Tuesday, May 20, 2008 12:00 1:00pm Lunch available at 11:45 Seminar begins at 12:00 Stevenson Center 5502 News posted by lori.michalowski@vanderbilt.edu: Hassane Mchaourab, Ph.D. Presents at MBTP May 6, 2008Molecular Biophysics Training Program Seminar Series / Center for Structural Biology Hassane Mchaourab, Ph.D. Presents: Living with Controversies: A Tale of two Transporters Tuesday, May 6, 2008 12:00 1:00pm Lunch available at 11:45 Seminar begins at 12:00 Stevenson Center 5502 News posted by lori.michalowski@vanderbilt.edu: Kurt Wuthrich, Ph.D., Nobel Laureate in Chemistry April 17Kurt Wthrich, Ph.D. Cecil H. and Ida M. Green Professor of Structural Biology, The Scripps Research Institute, La Jolla, CA Professor of Biophysics, ETH Zrich, Zrich, Switzerland Speaking on: New Trends in NMR Spectroscopy for Structural Biology and Structural Genomics Thursday, April 17, 2008 12:30 1:30pm MRB III, Room 1220 News posted by lori.michalowski@vanderbilt.edu: Brian Bachmann presents MBTP/CSB Seminar Series, April 1, 12:00pmBrian O. Bachmann, Ph.D. of Vanderbilt Chemistry Department Presents: Discovery of pharmacophore biosynthesis enzymes in bacteria. Tuesday, April 1, 2008. 12:00 pm. News posted by lori.michalowski@vanderbilt.edu: MBTP/CSB Seminar Series, March 18, 12:00pmBrian Weiner, Chazin Lab, Presents: Biochemical and structural analysis of the p58C and p68N domains of DNA polymerase alpha/primase. Lunch available at 11:45 - Seminar begins at 12:00 Stevenson Center 5502 News posted by lori.michalowski@vanderbilt.edu: Rachel Klevit, D. Phil., Biochemistry Monday Seminar SeriesRachel Klevit, D. Phil., Dept of Biochemistry University of Washington, Seattle, WA presents: Specificity and Diversity in the Function of BRCA1/BARD1 Ubiquitin E3 Ligase Monday, March 17, 2008 4:00 PM - 512 Light Hall Sponsored by: Department of Biochemistry, the Center for Structural Biology, and The National Cancer Institute Training Grant "Biochemical and Chemical Training for Cancer Research" Refreshments served at 3:45 p.m. News posted by lori.michalowski@vanderbilt.edu: Kurt Wuthrich, Ph.D., Nobel Laureate in Chemistry April 16Cecil H. and Ida M. Green Professor of Structural Biology, The Scripps Research Institute, La Jolla, CA, USA Professor of Biophysics, ETH Zrich, Zrich, Switzerland. April 16, 2008 (Wednesday) Lecture - "The NMR view of Proteins" Sponsor: Center for Structural Biology 4:00 p.m. / 208 Light Hall News posted by lori.michalowski@vanderbilt.edu: MBTP/CSB Seminar Series, March 4, 12:00pmClaus Schneider presents: "Old and not so old substrates for probing the mechanism of cyclooxygenases". Stevenson Center Room 5502. News posted by lori.michalowski@vanderbilt.edu: Kelly Conrads, ForteBio, Inc., February 20, 1pmJamshid Khoshnoodi hosts Kelly Conrads from ForteBio, Inc. to hold a seminar in PRB Room 317 on the Bio-Layer Interferometry & the Octet System Label-Free Protein Affinity, Kinetics, and Quantitation in Crude or Purified Samples Topics to be covered include:KINETICS Applications - Fast alternatives to Biacore Therapeutics R&D - Protein/Protein Interaction Analysis - Affinity characterization - Measure kinetic constants - Rank order affinities - Fast Kinetic Screening of Binding Proteins/Peptides and Antagonists QUANTITATION Applications - Fast Alternatives to HPLC and ELISA -Antibody Quantitation in 30 Minutes - Rapid Concentration Analysis from Tissue or Cell Culture Extracts ASSAY DEVELOPMENT, Protein-Protein Interactions News posted by lori.michalowski@vanderbilt.edu: MBTP/CSB Seminar Series, February 19, 12:00pmNews posted by lori.michalowski@vanderbilt.edu: Dorothee Kern, Brandeis University to speakProfessor Walter Chazin will host Dorothee Kern of Brandis University on April 7, 2008, 4:15-5:30 p.m. at 5211 Stevenson Center. News posted by lori.michalowski@vanderbilt.edu: Anne Karpay MemorialMemorial Service for: Anne Karpay 1981-2008 IGP Student, Biochemistry Ph.D. Candidate Thursday, January 17, 4:15pm Light Hall 208 News posted by lori.michalowski@vanderbilt.edu: MBTP/CSB Seminar Series, February 5, 12:00pmHeidi Hamm, Ph.D. Presents: "How receptors activate G proteins" 12:00 - 1:30 pm, SC5502 News posted by lori.michalowski@vanderbilt.edu: MBTP/CSB Seminar Series, January 15, 12:00pmNils Woetzel, Jens Meiler Lab presents, Computational Protein Structure prediction using knowledge based energy functions and experimental restraints. MRBIII, Room 1220. News posted by lori.michalowski@vanderbilt.edu: Special NMR Seminar 9 AM Friday, January 18"Strategies for Structure Determination of a Weak Binding, Fast Exchanging Carbohydrate-Protein Complex". Tiandi Zhuang, Prestegard Lab, University of Georgia, 9 AM, Friday January 18, Rm 5131 MRBIII. The talk will consist of two parts: 1. enhancement of RDCs through specific association between alkyl chain and alignment media. 2. Use of Paramagnetism-based constraints (RDC,PCS). Tiandi is a Sanders lab postdoc candidate. News posted by lori.michalowski@vanderbilt.edu: Special CSB Seminar - Friday August 3, 2007Dr. Ning Zheng, Presents:Ubiquitin Ligase Machinery:from Plant Biology to Human Disease Friday, August 3, 2007 12:00 1:30pm Stevenson Center Room 5202 Lunch available at 11:45 Seminar begins at 12:00 News posted by lori.michalowski@vanderbilt.edu: Guengerich Presents July 3, 2007, 12:00pmF. Peter Guengerich, Ph.D. Presents: Kinetic and structural approaches to understanding interactions of carcinogens, DNA, & DNA polymerases in Stevenson Center Room 5502 from 12:00 - 1:30pm News posted by lori.michalowski@vanderbilt.edu: Jian Shi, speaks June 19, 12:00pm, SC 5502Jian Shi Stewart Lab Presents: Mechanistic Insight of a structural study of Small Heat Shock Protein variants by cryo-electron microscopy Tuesday, June 19, 2007 12:00 1:30pm Lunch available at 11:45 Seminar begins at 12:00 Stevenson Center, Room 5502 News posted by jsmith@structbio.vanderbilt.edu: Walter Chazin receives Stanley Cohen Award for Outstanding Contributions to ResearchThe 2007 Faculty Awards, presented at the Spring Faculty Meeting, recognize excellence in teaching and in research. The awards for Outstanding Contributions to Research are named in honor of current and past Vanderbilt faculty who were recognized during their careers by election to the National Academy of Sciences. The Stanley Cohen Award For Research Bridging Diverse Disciplines, such as Chemistry or Physics, to Solve Biologys Most Important Fundamental Questions - was awarded to CSB director Walter Chazin, Ph.D., professor of Biochemistry, Chemistry; Ingram Professor of Cancer Research. Congratulations! News posted by lori.michalowski@vanderbilt.edu: Anne Kenworthy, May 1, 2007, 12:00pm SC5502Anne Kenworthy Presents:Biophysical analysis of membrane microdomains. Tuesday, May 1, 2007, 12:00 1:30pm. Lunch available at 11:45, Seminar begins at 12:00. Stevenson Center, Room 5502 News posted by lori.michalowski@vanderbilt.edu: Tennessee Structural Biology Symposium, June 21-23, 2007Tennessee Structural Biology Symposium, Doubletree Hotel Murfreesboro, TN. June 21-23, 2007. For registration form contact lori.michalowski@vanderbilt.edu. News posted by lori.michalowski@vanderbilt.edu: Markus Godejohann from Bruker BiospinSPECIAL PRESENTATION: Markus Godejohann from Bruker Biospin Presents:Theory and practice of LC-SPE-NMR/MS Tuesday, May 8, 2007 12:00 1:30pm Seminar begins at 12:00 Stevenson Center, Room 5502 News posted by lori.michalowski@vanderbilt.edu: OPEN HouseGuest Speakers: Dr. Kathy Gould presents: "Determining the architecture of a subcomplex within the spliceosome"; Dr. Timothy Cover presents: "Investigation of Helicobacter pylori and gastric cancer: a structural biology approach"; Dr. Daniel Liebler presents: Protein targets of damage by reactive electrophiles Friday, November 10, 2006, 1220 MRB III, 2:30 4:30 pm Reception to follow in 1st floor foyer News posted by lori.michalowski@vanderbilt.edu: Dr. Zhen Huang, speaks at CSB/MBTP Seminar, October 3, 2006Zhen Huang, Ph.D. Associate Professor Department of Chemistry of Georgia State University presents: Synthesis of Selenium Nucleic Acids (SeNA) for Structure and Function Studies of Nucleic Acids. Structure determination of RNAs, DNAs, and their protein complexes, which are potential drug targets, can provide insights on their structures and functions. X-ray crystallography is a powerful tool for the 3-D structure determination of these biomacromolecules although heavy atom derivatization for phase determination, a long-standing major problem in X-ray crystallography, has largely slowed down structural determination of nucleic acids with novel folds. In order to help solving this problem, we have first developed chemical and enzymatic syntheses of RNAs and DNAs derivatized with selenium by site-specifically replacing oxygen. We will present the chemical synthesis and enzymatic incorporation study of RNA and DNA containing Se-modifications, and present the structure study of the Se-modified DNAs and RNAs. This strategy of RNA and DNA derivatization with selenium has great potential as a general methodology in X-ray crystallography. This novel strategy will significantly facilitate nucleic acid X-ray crystallography and study of nucleic acid-protein complexes. News posted by lori.michalowski@vanderbilt.edu: Abbas Ourmazd lecture November 17, 3:00pmDr. Ourmazd is a very astute microscopist deep into the underlying physics of diffraction, especially with electron beams. He will give a lecture on "Crystallography without crystals: Deteriming the structure of biological molecules". Friday, November 17, 2006 at 3:00pm Stevenson Center, Physics 5th floor conference room (SC 6524). News posted by lori.michalowski@vanderbilt.edu: P. Shing Ho, Ph.D. visits VanderbiltP. Shing Ho, Ph.D. of Oregon State University presents: "Halogen bonds: An orthogonal interaction to hydrogen bonds?" On Tuesday, September 5th 12:00 - 1:30 in Stevenson Center room 5502. Dr. Ho will also be presenting: "From Holliday junctions to halogen bonds" at the VICB seminar 12:15 - 1:15 in MRB 3 1220. News posted by lori.michalowski@vanderbilt.edu: Vanderbilt Center for Structural Biology and Thermo Electron present, Larry DeLucas, O.D., Ph.D,Larry J. DeLucas, O.D., Ph.D, D.Sc.(hon.) Director, The Center for Biophysical Sciences and Engineering Director and Senior Scientist, UAB Comprehensive Cancer Center X-ray Crystallography Facility The University of Alabama, Birmingham speaking on: Advanced Technologies to Improve Expression/Crystallization for Difficult Proteins Several interrelated technologies employed at the CBSE are improving the success rate with difficult proteins. The following will be discussed: 1. An advanced protein expression system that has demonstrated the ability to produce mg quantities of membrane (and aqueous) proteins. Recent success will be shown with the Cystic Fibrosis Transmembrane Regulator (CFTR) Protein. 2. A new HTP analytical method for measuring Protein-Protein & Protein-Drug interactions that utilizes 2nd virile coefficient measurements as a quantitative predictor for protein crystallization and protein stability. This alternative method uses nanogram amounts with rapid quantitative outcomes that overcome the limitations typically associated with Static Light Scattering. 3. Several strategies will be discussed for the optimization of crystals including the use of neural networks and capillary counter diffusion techniques. Traditional individual capillary experiments require manual preparation & tedious harvesting procedures that currently make it secondary for those seeking HTP solutions. A new automated technology developed at the center will be described that embraces all of the advantages of a true liquid-liquid diffusion environment. 4:00 pm Tuesday, June 20, 2006 Room 1220 Biological Sciences/MRB III News posted by lori.michalowski@vanderbilt.edu: Introduction to CSB ResourcesThe CSB will host a seminar on Friday, April 7 from 2:00 - 4:00pm in PRB 206 to give an overview of the resources available in the CSB for those in the research community. Light refreshments will be provided. News posted by walter.chazin@vanderbilt.edu: Zhao wins SER-CAT awardOur very own Bin Zhao has been selected to receive the 2006 SER-CAT Outstanding Science Award! The award comes with an invitation to speak at the annual SER-CAT symposium, which will be held this year at Georgia State University on March 10th. News posted by Walter.Chazin@vanderbilt.edu: Lacy to give invited talk at National Biodefense MeetingOne of our two newest colleagues, Borden Lacy, has been invited to give a talk at the Fourth Research Conference on Biodefense in Washington DC. The conference is held annually by the American Society of Microbiology and provides a forum for cutting edge research advances in the field of biodefense attracting leading experts from all over the world. The title of her talk is Anthrax Toxin Receptors/Inhibitors. It will be given as part of the Plenary Session on The Role of Structural Biology in Biodefense. News posted by lori.michalowski@vanderbilt.edu: Molecular Biophysics Training Program SeminarBrian Datillo, Chazin Lab presents, "The Modular Structure of RAGE and its Macromolecular Interactions." News posted by veronda.mcclain@vanderbilt.edu: Structural Biology Mini-Symposium, Dec. 1, 2005 2-4pm2:00 pm Topic: A Tale of Two Macromolecular Assemblies by 3D Electron Microscopy Speaker: Phoebe Stewart, PhD Institution: VUMC Seminar Location: MRB3, Room 1220. 3:00 pm Topic: Trying to Elucidate Mechanisms of Eukaryotic Translation Initiation Speaker: Gerhard Wagner, PhD Institution: Harvard Medical School Seminar Location: MRB3, Room 1220 News posted by lori.michalowski@vanderbilt.edu: CSB Open HouseThe Center for Structural Biology will be holding an Open House on November 11. Presentations from 2-4 PM in 1220 BIOSCI/MRBIII will be followed by personalized tours of the facilities and a reception. All students, staff and faculty are encouraged to come by and learn about opportunities to apply structural biology approaches to their research and access cores and facilities. News posted by jarrod.smith@vanderbilt.edu: CSB Biomolecular Visualization Workshop - Oct. 12-13, 2005The CSB will host a two-session workshop in Biomolecular Visualization on October 12-13 from 1-4pm. This is an introductory workshop and assumes no prior knowledge or experience in the areas of molecular modeling or visualization. Beginners are encouraged to participate, as this is the target audience for this workshop. The fee for this workshop is $75, and will be limited to 13 participants. Please visit the workshop website for a syllabus and more details. News posted by m.sundaramoorthy@vanderbilt.edu: Tennessee Structural Biology Symposium - September 9-10, 2005TENNESSEE STRUCTURAL BIOLOGY SYMPOSIUM Center for Structural Biology September 9-10, 2005 Keynote Speaker For details contact: Sponsored by: News posted by lori.michalowski@vanderbilt.edu: Molecular Biophysics Training Program Seminar SeriesChu Wang, Graduate Student from University of Washington, Biochemistry Presenting Predicting Protein-protein Interactions by RosettaDock on: Tuesday, September 6, 2005 12:00 1:25pm Room SC5326. News posted by lori.michalowski@vanderbilt.edu: Molecular Biophysics Training Program Seminar Series August 16, 2005Kristina Furse presents, News posted by walter.chazin@vanderbilt.edu: Sanders Lab produces folded GCPR in E. coliThe paper shows excellent quality NMR spectra obtained for vasopressin V2 receptor expressed in E. coli!!! Solution NMR spectroscopy of the human vasopressin V2 receptor, a G protein-coupled receptor. Tian C, Breyer RM, Kim HJ, Karra MD, Friedman DB, Karpay A, Sanders CR, J Am Chem Soc 2005 Jun 8 127(22):8010-1. See also citation in Faculty of 1000: http://www.facultyof1000.com/article/15926814 News posted by lori.michalowski@vanderbilt.edu: Molecular Biophysics Training Program Seminar Series July 5, 2005Jens Meiler, Ph.D., Assistant Professor Presents Protein Ligand Interfaces From Flexible Docking to Enzyme Design Tuesday, July 5, 2005 12:00 1:25pm Chemistry Building, Room 5502 News posted by walter.chazin@vanderbilt.edu: Krezel and coworkers publish structure of RNP C coiled-coilThe Krezel group has just reported a high resolution solution NMR structure of the RNP C coiled-coil domain. See Journal of Molecular Biology, Vol. 350, Iss. 2, 2005, pages 319-337. News posted by walter.chazin@vanderbilt.edu: CSB researchers determine structural basis of multi-drug resistance transporterCongratulations to the Mchaourab lab (Dong J, Yang G, McHaourab HS), who published a major breakthrough in the May 13 issue of Science entitled, Structural basis of energy transduction in the transport cycle of MsbA. News posted by rita.r.urben@vanderbilt.edu: Potential Function Parameter Development Workshop
News posted by rita.r.urben@vanderbilt.edu: Recent Discoveries in Biochemistry Seminar Series, Murthy Karra, Ph.D.Dr. Murthy Karra will present a seminar in association with the Recent Discoveries in Biochemistry Seminar Series. His title is Structure Determination of Membrane Proteins Using NMR: Challenges and Progress. The seminar will be held on Thursday, February 3, 2005 at 4:00 in Room 836 RRB. Refreshments will be served. News posted by rita.r.urben @vanderbilt.edu: Dean's Lecture Series, John C. Gore, Ph.D. Invited SpeakerJohn C. Gore, Ph.D. is invited speaker for the Dean\'s Lecture Series. Dr. Gore is Chancellors University Professor and Director of the Vanderbilt University Institute of Imaging Science. His title is New Horizons in Biomedical Imaging Science. The seminar will be Wednesday, February 2 at 12:00 Noon in 202 Light Hall. Lunch will be provided to RSVP email janelle.owens@vanderbilt.edu News posted by rita.r.urben@vanderbilt.edu: Special VICB Mini-Symposium Wed. Feb 2Vanderbilt Institute of Chemical Biology is hosting a Mini-Symposium on Wednesday, February 2, 2005. The invited speakers are Dennis Dougherty of California Institute of Technology and Jeffrey Kelly of Scripps Research Institute.
News posted by rita.r.urben@vanderbilt.edu: Molecular Biophysics Training Program Seminar, Dr. Michael Waterman SpeakerDr. Michael Waterman, Professor and Chariman of Biochemistry at Vanderbilt University School of Medicine is the invited speaker for the Molecular Biophysics Training Program Seminar on Tuesday, February 1, 2005. His title is Sterol 14α-Demethylase: A Cytochrome P450 Which is an Important Drug Target. The seminar is held at 12:00 in the Chemistry Building, Room 5502. Lunch will be provided. For additional information please contact rita.r.urben@vanderbilt.edu. News posted by rita.r.urben@vanderbilt.edu: Special Biochemistry Seminar, Hartmut Oschkinat SpeakerOn Friday, January 28th at 12:00 Noon Hartmut Oschkinat with the Department of NMR - Supported Structural Biology Forshungsinstitut fur Molekulare Pharmakologie; Berlin, Germany will present a special seminar sponsored by the Biochemistry Department. Seminar title is Proteins and their Interactions Studied by Solutions and Solid-State NMR. The seminar will be held in Room 206 PRB. News posted by rita.r.rurben@vanderbilt.edu: Department of Biochemistry Seminar Thursday, January 27, 2005 Carmen A. Perez SpeakerThe Department of Biochemistry has invited Carmen A. Perez to present a seminar as part of the Recent Discoveries in Biochemistry Seminar Series. The title of the seminar is Defining the Function of p63 in Breast Myoepithelial Cells. The seminar will be held Thursday, January 27th at 4:00 in Room 836 RRB. Refreshmnets will be served. News posted by rita.r.urben@vanderbilt.edu: Special Lecture; John Dani, Ph.D. Chancellor\'s Chair CandidateDr. John Dani, Professor Department of Neuroscience, Menninger Dept of Psychiatry & Behavioral Science, Program in Structural & Computational Biology & Molecular Biophysics of Baylor College of Medicine will present a seminar on Tuesay, January 25th at 10:00AM in 208 Light Hall. Dr. Dani is a candidate for the Chancellor\'s Chair. His title is Cholinergic and Dopaminergic Mechanisms Contributing to Nicotine Addition. News posted by rita.r.urben@vanderbilt.edu: Institute of Chemical Biology ,David Gin SeminarDavid Gin of the University of Illinois, Urbana Champaign Department of Chemistry will present a seminar on Wednesday, January 26th at 12:15 in Room 1220; BSB/MRB III. His title is Exploring Strategies for Carbohydrate and Alkaloid Synthesis. For additional information contact Anne.B.Lara@Vanderbilt.edu. News posted by rita.r.rurben@vanderbilt.edu: Professor Wolfgang Driever SeminarThe Departments of Biological Science and the Developmental Biology Program and Fish Initiative have invited Professor Wolgang Driever to present a seminar. Dr. Driever is Hans Spemann Professor of Developmental Biology at Freiburg University in Germany. His title is Developmental Neurogenetics in Zebrafish: Cell Specification in the Dopaminergic and Noradrenergic Systems. The seminar will be Thursday, January 27th at 12:15pm in Room 1220 BSB/MRB III. News posted by rita.r.urben@vanderbilt.edu: Department of Biological Sciences Seminar, Chris Janetopoulos, Ph.D.Faculty candidate Dr. Chris Janetopoulos of Johns Hopkins University School of Medicine is invited speaker on Monday, January 24th at 4:10; Room 1220 BSB/MRB III. His title is Polarity Circiuts in Migrating and Dividing Cells. News posted by rita.r.urben@vanderbilt.edu: Biochemistry Seminar, Speaker Tim Stearns, Ph.D.Dr. Tim Stearns of Stanford University is the guest speaker on Monday, January 24th for
News posted by rita.r.urben@vanderbilt.edu: Center in Molecular Toxicology Seminar, John T.Stivers, Ph.D.James T. Stivers,Ph.D. Associate Professor of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine is invited speaker on Friday, January 21, 2005 at 4:00; 512 Light Hall.
News posted by rita.r.urben@vanderbilt.edu: Molecular Biophysics Traininig Program SeminarDr. Laura Busenlehner is the invited speaker for the Tuesday, January 18th Molecular Biophysics Training Program Seminar. Her title is Extension of Amide H/D Exchange Mass Spectrometry to Membrane Proteins. The seminar will be at 12:00 in the Chemistry Building, Room 5502.(Note this is a new location). Lunch will be provided. For additional information please contact Rita Urben, rita.r.urben@vanderbilt.edu News posted by tina.mccoy@vanderbilt.edu: Scientist Receive AAAS HonorNASHVILLE, Tenn. Four Vanderbilt scientists Walter J. Chazin, Director, Center for Structural Biology, Raymond N. Dubois Jr., Leonard C. Feldman and Dennis G. Hall have been elected as fellows of the American Association for the Advancement of Science (AAAS), an honor bestowed upon them by their peers. They are being honored for contributions to research that runs the gamut from determining the atomic structure of proteins to paving the way for improved treatments of digestive diseases including colon cancer, from investigating the atomic structure of materials to providing new insights into the fundamental nature of light.
News posted by rita.r.urben@vanderbilt.edu: Mini-Symposium, Thursday, December 16, 2004The Center for Structural Biology is hosting a Mini-Symposium
News posted by walter.chazin@vanderbilt.edu: KaiC structure from Egli lab on the cover of Molecular CellThe structure of cyanobacterial clock protein KaiC determined by CSB faculty member was Martin Egli and coworkers appears on the cover of the August 13 issue of Molecular Cell. The structure has revealed important insights into the workings of the circadian clock and the linkage to gene expression. This study is a collaboration with Carl Johnson from the Dept. of Biological Science. News posted by jarrod.smith@vanderbilt.edu: SGI/Vanderbilt Press ReleaseSGI has issued a press release announcing our partnership with them in building a visualization center around their Onyx4 technology. See it here.
News posted by walter.chazin@vanderbilt.edu: CSB Open House!!Please mark you calendars for Friday afternoon November 5 for a Center for Structural Biology Open House.
News posted by mizoue@structbio.vanderbilt.edu: Bowie seminars: April 21 and 22James Bowie, Associate Professor in the
News posted by walter.chazin@vanderbilt.edu: Sanders shows importance of membrane protein folding in diseaseWhy Do Cells Care About Membrane Protein Stability? Chuck Sanders and Joanna Nagy, Biochemistry 43, 10-25, (2004) Dept. of Biochemistry, Center for Structural Biology, Institute for Chemical Biology It is becoming apparent that mammalian cells have a tendency to degrade proteins having relatively low thermodynamic stability, even though the equilibrium constant for folding may still strongly the folded state by a factor of 1000 or more. Indeed, a new paradigm in drug development is presently being explored based on the fact that exogenous compounds which stabilize stability-challenged proteins are able to rescue such proteins from degradation, so that the protein\'s function is maintained in the cell. However, it is not clear why cells devote so many resources to monitoring protein stability. One possibility is that cells are not so much concerned about stability as they are about some other property which is linked to stability, such as a protein\'s tendency to misfold into kinetically-trapped aberrant structural states. In our work the relationship between stability and propensity to misfold was probed for a series of purified variants of the polytopic integral membrane protein diacylglycerol kinase. It was observed that there was a strong correlation between stability and folding efficiency. The most common mutations which promoted misfolding were those which also destabilized the protein. These results imply that by targeting unstable membrane proteins for degradation, cellular protein folding quality control can eliminate proteins that have a high intrinsic propensity to misfold into aberrant structures. Moreover, the more rare class of amino acid mutations which promote misfolding without perturbing stability may be particularly dangerous because the mutant proteins may evade the surveillance of cellular quality control systems. Such proteins would not only lose function, but might misfold to form toxic structures such as amyloids. News posted by joel.harp@vanderbilt.edu: DataCentric Automation Seminar, Feb. 245131 MRBIII 10-11:30 a.m. News posted by mizoue@structbio.vanderbilt.edu: Light Scattering Technology Seminar: Feb. 10thRon Myers from Wyatt Technology Corporation will present a seminar on Multi-angle light scattering (MALS) and Quasi-elastic light scattering (QELS) theory, instrumentation, and applications for macromolecules. MALS is routinely used to determine biopolymer molar masses and radii, protein aggregation, protein glycosylation, critical micelle concentrations, polymer branching, polymer shape, and polymer viscosity. QELS can be used to determine the hydrodynamic radii of biopolymers with radii as low as 1 or 2 nm thus making it an excellent complement to MALS. News posted by l.mizoue@vanderbilt.edu: Kovall Seminar - January 15 at 3:30Faculty Candidate Dr. Rhett Kovall has been invited to present a seminar. Dr. Kovall is currently in the Department of Biochemistry and Molecular Biophysics at the Howard Hughes Medical Center at Columbia University.
Nucleus: The Crystal Structure of CSL bound to DNA. Thursday, January 15th, 3:30-4:55pm Room 1220 MRBIII News posted by jarrod.smith@vanderbilt.edu: Data visualization technology demo - Wed. Nov 12See SGI demonstrate their new graphics supercomputer, the Onyx4, right here at Vanderbilt! Information on the Onyx4 is available at SGI's website. It will be set up in tandem with JRTI's VizEveryWhere 3D immersive projection system. The demo will start at 1:30 and last approximately 90 minutes. We will meet in 5119 Stevenson Center (first floor of the science and engineering building). If you have a current or future need for data visualization, please come and show your interest! News posted by Thomas.McClure@Vanderbilt.edu: CSB Social HourTheVanderbilt Center for Structural Biology
News posted by mizoue@structbio.vanderbilt.edu: Seminar AnnouncementDr. James Keck, Asst. Prof., University of Wisconsin, Madison
News posted by mizoue@structbio.vanderbilt.edu: Center for Structural Biology Fellowship AnnouncementThe Center for Structural Biology (CSB) invites applications for graduate student and postdoctoral fellowships. The fellowship provides salary support to develop projects that use structural and biophysical approaches to address biological problems. Preference will be given to proposals designed to advance projects to the stage that demonstrates feasibility of structural analysis by NMR and/or X-ray crystallography.
Those selected for further review will be asked to submit a 3 page proposal due on October 6, 2003. Funds will be made available as soon as the decisions are made, no later than October 15, 2003. Please submit applications to the Center for Structural Biology, 5142 BIOSCI/MRBIII. Questions can be directed to: Laura Mizoue (x6-2253). News posted by walter.chazin@vanderbilt.edu: Center for Structural Biology Annual ReportThe Annual Report for fiscal 2002/2003 is now available. Please contact Melba Carpenter to obtain a copy. News posted by walter.chazin@vanderbilt.edu: Gerald Stubbs leads new fibre diffraction networkA network of fiber diffraction groups has been established to coordinate activities in the USA. The goal of the network is to develop biological fiber diffraction methods, particularly computational methods. This will be done through a program of software development, and through a series of retreats and workshops. The network software will be complementary to CCP13 software; together, they will eventually cover all aspects of biological fiber diffraction. A major focus of activity will be cooperation between fiber diffractionists in the USA and others, particularly those in Britain. A second focus will be the coordinated use of the BioCAT X-ray beamline facility at the Advanced Photon Source, Argonne National Laboratory. Network meetings will include three types of activity: retreats that will formalize a successful informal series held sporadically since 1989, workshops at BioCAT, and partial sponsorship of sessions organized by the fiber diffraction Special Interest Group of the American Crystallographic Association. The network, formally known as Research Coordination Network: Fiber Diffraction from Biological Polymers and Assemblies, and informally as FiberNet, is supported by the National Science Foundation\'s Division of Molecular and Cellular Bioscience, through grant MCB-0234001. News posted by bandix@structbio.vanderbilt.edu: Structbio Gathering: 15 November 2002Thanks to Kristina Furse for her artistic efforts. News posted by symposia@structbio.vanderbilt.edu: Vanderbilt Biomolecular Modeling SymposiumThe Center for Structural Biology at Vanderbilt University will host a biomolecular modeling symposium and poster session on Friday and Saturday, September 20-21, 2002. Registration is required, but free (see below). Refreshments will be provided for the poster session on Friday night. Continental breakfast will be provided before the symposium on Saturday morning. The poster session will be judged, and the winner will receive a prize in the amount of $250. To participate in the contest, check the appropriate box on the registration page and enter your poster's title and abstract in the space provided. Be sure to sign up quickly as seating will be limited to about 120. Registration is on a first-come, first served basis. We reserve the right to limit the number of registrants from any single organization to ensure an appropriate cross-section in the attendance, but only if space becomes a problem. The deadline for registration is Friday, September 13, 2002. Please report cancellations to symposia@structbio.vanderbilt.edu by Friday, September 13, 2002 as well. News posted by kristina.e.furse@vanderbilt.edu: Structural Biology Social Hour: 14 June 2002Come and join us for a drink and some munchies at the next general gathering of the Center for Structural Biology. It will be held on Friday June 14th in the Biochemistry Conference Room (RRB-836) at 4:00 pm. Here is your personal invitation: News posted by l.mizoue@vanderbilt.edu: Structural Biology Postdoctoral Fellowship AnnouncementVanderbilt University Center for Structural Biology Postdoctoral Funding Opportunity. The Center for Structural Biology invites applications for postdoctoral fellowships. The intent is to encourage faculty to develop projects that use structural and biophysical approaches to address biological problems and to advance projects to the stage that demonstrates feasibility of structural analysis by NMR and/or X-ray crystallography. Funding will be awarded for a 1-year period to support projects from individual investigators or collaborative teams. Competitive renewal for a 2nd year is possible. The stipend is $32,000/year plus full benefits with full access to equipment and instrumentation within the Center. Funding is open to all Vanderbilt faculty. Letters of intent are due on July 1, 2002. Those selected for further review will be asked to submit a three-page proposal due on July 25, 2002. Funds will be made available as soon as the decisions are made, no later than September 1, 2002. Please submit applications to the Center for Structural Biology (PRB 896). Questions can be directed to: Dr. Laura Mizoue, (6-2253) l.mizoue@vanderbilt.edu News posted by lybrand@structbio.vanderbilt.edu: Seminar AnnouncementPrediction of Peptide Binding to Families of Related Receptors, presented by Dr Vladimir Brusic, Thursday, 2:00 P.M., May 16, 2002 at Vanderbilt University, 836 RRB. Synopsis: Major histocompatibility complex (MHC) molecules bind peptides and present them on cell surface for recognition by T cells of the immune system. MHC molecules are encoded by genes that show significant polymorphism. In humans, there are more than 500 characterised allelic variants of MHC for each MHC class I and class II. We developed a prediction system called MULTIPRED that was trained using virtual sequences that represent peptide-MHC interactions. The virtual sequences were constructed by combining the interaction sites from both peptide (ligand) and the receptor (MHC) inferred from the three-dimensional structure of MHC molecules. We applied the MULTIPRED system to a selection of human MHC class II molecules HLA-DR, and to the human MHC class I superfamily HLA-A2. MULTIPRED showed high accuracy in predicting HLA-binding peptides. In addition, we have shown that MULTIPRED can accurately predict peptide binding to HLA molecules for which no binding data are available. Biographical Information: Dr Vladimir Brusic is a research manager and the Head of the BioDiscovery Group at the Laboratories for Information Technology, Singapore. His current work includes computational modelling of biological systems, computational simulations of laboratory experiments, biological data warehousing, and functional genomics. Between 1989 and 1998, Dr Brusic was a bioinformatician at the Walter and Eliza Hall Institute in Melbourne, Australia. He has a Doctoral degree in Bioinformatic and Master degrees in Biomedical Engineering, Information Technology, and Business Administration. Dr Brusic has published more than 50 articles in a broad range of bioinformatic fields. News posted by jaison.jacob@vanderbilt.edu: Phase errors in XWINNMR 3.0Many of you are aware of the recent upgrade of XWINNMR to version 3.0. This software had a bug in the phase incrementation routine and the problem has been fixed. Please refer to VUBNMR News for more information. News posted by kristina.e.furse@vanderbilt.edu: Structural Biology Social Hour: 15 March 2002Come and join us for a drink and some munchies at the next general gathering of the Center for Structural Biology. It will be held on Friday March 15th in the Biochemistry Conference Room (RRB-836) at 4:00 pm. Here is your personal invitation: News posted by walter.chazin@vanderbilt.edu: Center for Structural Biology gatheringCome and join us for a drink and some munchies at the next general gathering of the Center for Structural Biology. It will be held on November 16 in the Biochemistry Conference Room (RRB-836) at 4:00. There will be a brief presentation in the form of a progress report on our development plan and the upcoming move to the new BIOSCI/MRBIII building. News posted by webmaster@structbio.vanderbilt.edu: News Site has been Updated!!!The Structural Biology news center has been updated with two new features.. The first one is an editing feature which allows you to make changes to your submission before you actually submit your article.. The edit button will take you back to your form for you to make changes.. Secondly, when you click the preview button, another page will come up. This page lets you see what your article will look like once its on the internet. The preview page does not mean it has been actually submitted.. Only when you click the submit button is when your article is submitted.. With any questions or comments, email the webmaster by clicking the webmaster link..
thankyou
News posted by vbnmr@structbio.vanderbilt.edu: Vanderbilt Biomolecular NMR Symposium...On Saturday October 6, 2001, The Center for Structural Biology will host a biomolecular NMR symposium. Registration is required, but free. Please visit the symposium homepage for more information. Contact vbnmr@structbio.vanderbilt.edu with questions. News posted by walter.chazin@vanderbilt.edu: A welcome to our readershipPlease be sure to make use of this feature. It is a great way for us to stay in contact and updated on progress. And a big thanks to Jarrod and his group for the continued evolution of this website. News posted by jsmith@structbio.vanderbilt.edu: Structural Biology Homepage gets a new look...We've revamped the home page to make it easier to view and navigate. Please send feedback to webmaster@structbio.vanderbilt.edu | |||||||||||||||||||||||||||||||||
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